10 research outputs found
Peptide deformylase inhibitor actinonin reduces celastrol’s HSP70 induction while synergizing proliferation inhibition in tumor cells
Estudio de la formación de contaminantes fotoquímicos mediante la modelación matemática y sus efectos en la salud en el Valle de Aburra
IP 1210-13-234-98PONENCIA(S) EN CONGRESO: Numeral investigation of meteorologicalconditions leading to elevated ozone;concentrations in Medellin, Colombia / P. Sahm ... [et al.]. --En: International Conference on Urban Air;Quality and Saturn Workshop (3, 5 : 2001 Mar. 19-23 : Loutraki,Grecia). -- [s.l. : s.n.], 2001. -- p. ; 28;cm. -- Emission inventory in Medellin (Colombia) city : anaproximation /M.V. Toro ... [et al.]. -- En:;contaminantes atmosfericos en la ciudad de Medellin mediante factores de emision Corinar / M. Victoria Toro G.;... [et al.] -- En: Acodal -- Vol. 191 (2002); p. -- ISSN120798 -- Diagnostico de la calidad del aire en el;ancon sur del valle de Aburra / Maria Victoria Toro ... [et al.]'-- en: Contaminacion ambiental. -- Vol. 17,;no. 30-31 (2000); p. 93-103. -- ISSN 01200674.;International Conference on Urban Air Quality and Saturn Workshop (3, 5 :2001 Mar. 19-23 : Loutraki, Grecia).; [s.l. : s.n.], 2001. -- p. ; 28 cm. -- ARTICULO(S) EN REVISTA: Calculode la emision vehicular d
Effects of civil war: scientific cooperation in the republics of the former Yugoslavia and the province of Kosovo
Indirect tool monitoring in drilling based on gap sensor signal and multilayer perceptron feed forward neural network
Sulphur deposition on the Italian area: a trajectory model study
2nonenoneCALORI G.; FINZI G.Calori, G.; Finzi, Giovann
Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise
All cells have developed various mechanisms to respond and adapt to a variety of environmental challenges, including stresses that damage cellular proteins. One such response, the heat shock response (HSR), leads to the transcriptional activation of a family of molecular chaperone proteins that promote proper folding or clearance of damaged proteins within the cytosol. In addition to its role in protection against acute insults, the HSR also regulates lifespan and protects against protein misfolding that is associated with degenerative diseases of aging. As a result, identifying pharmacological regulators of the HSR has become an active area of research in recent years. Here, we review progress made in identifying small molecule activators of the HSR, what cellular targets these compounds interact with to drive response activation, and how such molecules may ultimately be employed to delay or reverse protein misfolding events that contribute to a number of diseases. © 2012 American Chemical Society