10 research outputs found

    Estudio de la formación de contaminantes fotoquímicos mediante la modelación matemática y sus efectos en la salud en el Valle de Aburra

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    IP 1210-13-234-98PONENCIA(S) EN CONGRESO: Numeral investigation of meteorologicalconditions leading to elevated ozone;concentrations in Medellin, Colombia / P. Sahm ... [et al.]. --En: International Conference on Urban Air;Quality and Saturn Workshop (3, 5 : 2001 Mar. 19-23 : Loutraki,Grecia). -- [s.l. : s.n.], 2001. -- p. ; 28;cm. -- Emission inventory in Medellin (Colombia) city : anaproximation /M.V. Toro ... [et al.]. -- En:;contaminantes atmosfericos en la ciudad de Medellin mediante factores de emision Corinar / M. Victoria Toro G.;... [et al.] -- En: Acodal -- Vol. 191 (2002); p. -- ISSN120798 -- Diagnostico de la calidad del aire en el;ancon sur del valle de Aburra / Maria Victoria Toro ... [et al.]'-- en: Contaminacion ambiental. -- Vol. 17,;no. 30-31 (2000); p. 93-103. -- ISSN 01200674.;International Conference on Urban Air Quality and Saturn Workshop (3, 5 :2001 Mar. 19-23 : Loutraki, Grecia).; [s.l. : s.n.], 2001. -- p. ; 28 cm. -- ARTICULO(S) EN REVISTA: Calculode la emision vehicular d

    Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise

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    All cells have developed various mechanisms to respond and adapt to a variety of environmental challenges, including stresses that damage cellular proteins. One such response, the heat shock response (HSR), leads to the transcriptional activation of a family of molecular chaperone proteins that promote proper folding or clearance of damaged proteins within the cytosol. In addition to its role in protection against acute insults, the HSR also regulates lifespan and protects against protein misfolding that is associated with degenerative diseases of aging. As a result, identifying pharmacological regulators of the HSR has become an active area of research in recent years. Here, we review progress made in identifying small molecule activators of the HSR, what cellular targets these compounds interact with to drive response activation, and how such molecules may ultimately be employed to delay or reverse protein misfolding events that contribute to a number of diseases. © 2012 American Chemical Society

    Changes in terrestrial near-surface wind speed and their possible causes: an overview

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    Small Molecule Activators of the Heat Shock Response: Chemical Properties, Molecular Targets, and Therapeutic Promise

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