Effect of Different Doses of Exercise on Sleep Duration, Sleep Efficiency and Sleep Quality in Sedentary, Overweight Men

Objective: To evaluate the dose-response effect of aerobic exercise on sleep duration, sleep efficiency and sleep quality in previously sedentary, moderately overweight men. Methods: In a randomized, controlled trial, 53 sedentary Caucasian men aged between 20 and 40 years (VO2- max<45 mL O2 kg-1 min-1, BMI: 25-30 kg/m2, body fat>25%) completed a 13-week aerobic exercise intervention consisting of either a physical activity energy deficit of 600 kcal day-1 (HIGH: n=18), 300 kcal day-1 (MOD: n=18), or being sedentary (CON: n=17). The endpoints were sleep duration (objectively measured by actigraphy over 3 days), sleep efficiency (3-day actigraphy), and subjectively rated sleep quality (Pittsburgh Sleep Quality Index). Results: Because of missing sleep data, a total of 32 subjects were included in the present analysis (CON: n=12, MOD: n=12, HIGH: n=8). A significant increase in sleep duration was observed in HIGH (80 ± 30 min, p=0.03). However, the change was not significantly different from the change in CON. Sleep efficiency tended to decrease in HIGH (p=0.05), and there was a tendency towards an improved sleep quality within MOD and HIGH (p=0.08 in both). Conclusion: Our study suggests that a high daily dose of aerobic exercise for 13 weeks increases sleep duration, tends to decrease sleep efficiency, and tends to improve subjective sleep quality in sedentary, moderately overweight men. Because our sample included relatively young and sleep-efficient individuals, future studies should examine the dose-response effects of aerobic exercise on sleep parameters in older adults with sleeping problems

Maintenance treatment with azacytidine for patients with high-risk myelodysplastic syndromes (MDS) or acute myeloid leukaemia following MDS in complete remission after induction chemotherapy

P>This prospective Phase II study is the first to assess the feasibility and efficacy of maintenance 5-azacytidine for older patients with high-risk myelodysplastic syndrome (MDS), chronic myelomonocytic leukaemia and MDS-acute myeloid leukaemia syndromes in complete remission (CR) after induction chemotherapy. Sixty patients were enrolled and treated by standard induction chemotherapy. Patients that reached CR started maintenance therapy with subcutaneous azacytidine, 5/28 d until relapse. Promoter-methylation status of CDKN2B (P15 ink4b), CDH1 and HIC1 was examined pre-induction, in CR and 6, 12 and 24 months post CR. Twenty-four (40%) patients achieved CR after induction chemotherapy and 23 started maintenance treatment with azacytidine. Median CR duration was 13 center dot 5 months, > 24 months in 17% of the patients, and 18-30 center dot 5 months in the four patients with trisomy 8. CR duration was not associated with CDKN2B methylation status or karyotype. Median overall survival was 20 months. Hypermethylation of CDH1 was significantly associated with low CR rate, early relapse, and short overall survival (P = 0 center dot 003). 5-azacytidine treatment, at a dose of 60 mg/m2 was well tolerated. Grade III-IV thrombocytopenia and neutropenia occurred after 9 center dot 5 and 30% of the cycles, respectively, while haemoglobin levels increased during treatment. 5-azacytidine treatment is safe, feasible and may be of benefit in a subset of patients

Update of annual calving front lines for 47 marine terminating outlet glaciers in Greenland (1999–2018)

The Greenland ice sheet has been losing mass in response to increased surface melting (Khan&nbsp;et al. 2015; van den Broeke&nbsp;et al. 2017) as well as discharge of ice from marine terminating outlet glaciers (van den Broeke&nbsp;et al. 2009; Box&nbsp;et al. 2018). Marine terminating outlet glaciers flow to the ocean where they lose mass by e.g. iceberg calving. Currently, the mass loss from the Greenland ice sheet is the largest Arctic contributor to global sea-level rise (van den Broeke&nbsp;et al. 2009, 2017; Box&nbsp;et al. 2018). Therefore, monitoring&nbsp;changes in the Greenland ice sheet is essential to provide policy makers with reliable data. There is a consensus that most&nbsp;marine terminating outlet glaciers have retreated in recent decades, and that the increased calving rates are a response to recent atmospheric and oceanic warming (e.g. Box&nbsp;et al. 2018; Moon&nbsp;et al. 2018). The rate of dynamic mass loss is determined by changes of the glacier calving front (i.e. its terminus) position, ice thickness and changes in ice flow.&nbsp;Ocean temperature and fjord circulation also influence the calving front stability by melting the glacier below the water line, thinning the ice that is in contact with water (Moon&nbsp;et al. 2014). Change in calving front position is therefore an important indicator for monitoring the dynamic behaviour of the upstream area of the ice sheet, which is further modulated by local topographic features and buttressing effects (Rignot &amp; Kanagaratnam 2006; Nick&nbsp;et al. 2009). The Programme for Monitoring of the Greenland Ice Sheet (PROMICE) is dedicated to monitoring changes in the mass budget of the Greenland ice sheet, including monitoring of the calving front lines of&nbsp;marine terminating outlet glaciers. Here, we present an updated collection of annual measurements of end-of-melt-season calving front lines for 47 marine terminating outlet glaciers in Greenland between 1999 and 2018. We also present an example application of the data set, in which we estimate area changes for this group of glaciers since 1999. The Greenland calving front lines were measured from optical satellite imagery obtained from Landsat, Aster, and Sentinel-2 (Table 1). The&nbsp;PROMICE calving front product&nbsp;is freely available for download as ESRI shapefiles

Kepler Asteroseismology Program: Introduction and First Results

Asteroseismology involves probing the interiors of stars and quantifying their global properties, such as radius and age, through observations of normal modes of oscillation. The technical requirements for conducting asteroseismology include ultrahigh precision measured in photometry in parts per million, as well as nearly continuous time series over weeks to years, and cadences rapid enough to sample oscillations with periods as short as a few minutes. We report on results from the first 43 days of observations, in which the unique capabilities of Kepler in providing a revolutionary advance in asteroseismology are already well in evidence. The Kepler asteroseismology program holds intrinsic importance in supporting the core planetary search program through greatly enhanced knowledge of host star properties, and extends well beyond this to rich applications in stellar astrophysics