37 research outputs found
分子科学に関連したユーザ会の報告
EDTAキレート化合物の理論的研究[安島,三次] 種々のパーフルオロカーボン陽イオンの構造と反応性 [古屋] エネルギー変換と分子認識に関する計算超分子化学の展開[杉本] Elongation method for large systems[Gu,Makowski,Korchowiec,青木] ポリフェノールデンドリマーの化学発光特性及び計算化学による分子構造解析[中園,阿川,南部,財津] 非経験的分子軌道法に基づくN-ドメイン特異的ACE阻害ペプチドの理論的予測とその評価[浦崎,益田] 非経験的分子軌道法による活性アルキル基の反応性の検討Ⅸ溶媒効果を考慮したAljyl NitriteによるIsovalerophenoneのニトロソ化反応機構[池田
A comparison of the ultrasonography images of the joints of patients with rheumatoid arthritis and the corresponding synovial histological findings
EVALUATION OF LANDSCAPE ARCHITECTURE METHOD AND CONTINUED VIADACT DESIGN BASED ON THE CONCEPT IN THE URBAN SUBURBS
Effects of surgical intervention on disease activity of rheumatoid arthritis: Cases of surgery for rheumatoid arthritis of the lower limbs treated with biologics
Serum Immunoglobulin G Levels to Porphyromonas gingivalis Peptidylarginine Deiminase Affect Clinical Response to Biological Disease-Modifying Antirheumatic Drug in Rheumatoid Arthritis.
To determine whether serum immunity to Porphyromonas gingivalis peptidylarginine deiminase (PPAD) affects the clinical response to biological disease-modifying antirheumatic drug (bDMARD) in patients with rheumatoid arthritis (RA).In a retrospective study, rheumatologic and periodontal conditions of 60 patients with RA who had been treated with conventional synthetic DMARD were evaluated before (baseline) and after 3 and 6 months of bDMARD therapy. After serum levels of anti-PPAD immunoglobulin G (IgG) were determined at baseline, the patients were respectively divided into two groups for high and low anti-PPAD IgG titers according to the median measurements. Genotypes at 8 functional single nucleotide polymorphisms (SNPs) related to RA were also determined.After 3 and 6 months of therapy, patients with low anti-PPAD IgG titers showed a significantly greater decrease in changes in the Disease Activity Score including 28 joints using C-reactive protein (DAS28-CRP) (P = 0.04 for both) and anti-cyclic citrullinated peptide (CCP) IgG levels (P = 0.03 and P = 0.04) than patients with high anti-PPAD IgG titers, although these parameter values were comparable at baseline. The anti-PPAD IgG titers were significantly positively correlated with changes in the DAS28-CRP (P = 0.01 for both) and the anti-CCP IgG levels (P = 0.02 for both) from baseline to 3 and 6 months later. A multiple regression analysis revealed a significantly positive association between the anti-PPAD IgG titers and changes in the DAS28-CRP after 6 months of bDMARD therapy (P = 0.006), after adjusting for age, gender, smoking, periodontal condition, and RA-related SNPs.The serum IgG levels to PPAD affect the clinical response to bDMARD in patients with RA