Triaxial superdeformation in 40^{40}Ar

Superdeformed (SD) states in $^{40}$Ar have been studied using the deformed-basis antisymmetrized molecular dynamics. Low energy states were calculated by the parity and angular momentum projection (AMP) and the generator coordinate method (GCM). Basis wave functions were obtained by the energy variation with a constraint on the quadrupole deformation parameter $\beta$, while other quantities such as triaxiality $\gamma$ were optimized by the energy variation. By the GCM calculation, an SD band was obtained just above the ground state (GS) band. The SD band involves a $K^\pi = 2^+$ side band due to the triaxiality. The calculated electric quadrupole transition strengths of the SD band reproduce the experimental values appropriately. Triaxiality is significant for understanding low-lying states.Comment: 11 pages, 4 figure

Development of transgenic male-sterile rice by using anther-specific promoters identified by comprehensive screening of the gene expression profile database ‘RiceXPro’

Because genomic selection is designed for the population breeding of allogamous species, a successive outcrossing system is required for efficient use of genomic selection in autogamous crops, such as Oryza sativa L. (rice). Transgenic and dominant male-sterility is a suitable tool for efficient outcrossing of autogamous crops. Though there have been some reports of dominant male-sterile rice developed using transgenic technology, the flowering habit was substandard. Here, to isolate promoters that, when linked to a lethal gene, induce dominant male-sterility while retaining a good flowering habit, we identified 38 candidate genes with anther-specific expression by using the ‘RiceXPro’ database. We then evaluated the abilities of the near-upstream regions of these genes to induce male-sterility when linked to the lethal gene barnase and introduced into the rice cultivar ‘Nipponbare’. Seven of the 38 promoters induced clear dominant male-sterility; promoters expressed in the later stage of anther development induced male-sterility while retaining better flowering habits when compared to ones expressed in the early stage. These seven promoters could potentially be used to facilitate development of an efficient outcross-based breeding system in rice

Development and characterization of transgenic dominant male sterile rice toward an outcross-based breeding system

Genomic selection is attracting attention in the field of crop breeding. To apply genomic selection effectively for autogamous (self-pollinating) crops, an efficient outcross system is desired. Since dominant male sterility is a powerful tool for easy and successive outcross of autogamous crops, we developed transgenic dominant male sterile rice (Oryza sativa L.) using the barnase gene that is expressed by the tapetum-specific promoter BoA9. Barnase-induced male sterile rice No. 10 (BMS10) was selected for its stable male sterility and normal growth characteristics. The BMS10 flowering habits, including heading date, flowering date, and daily flowering time of BMS10 tended to be delayed compared to wild type. When BMS10 and wild type were placed side-by-side and crossed under an open-pollinating condition, the seed-setting rate was <1.5%. When the clipping method was used to avoid the influence of late flowering habits, the seed-setting rate of BMS10 increased to a maximum of 86.4%. Although flowering synchronicity should be improved to increase the seed-setting rate, our results showed that this system can produce stable transgenic male sterility with normal female fertility in rice. The transgenic male sterile rice would promote a genomic selection-based breeding system in rice

Polymorphisms in the Taste Receptor Gene (Tas1r3) Region are Associated with Saccharin Preference in 30 Mouse Strains.

The results of recent studies suggest that the mouse Sac (saccharin preference) locus is identical to the Tas1r3 (taste receptor) gene. The goal of this study was to identify Tas1r3 sequence variants associated with saccharin preference in a large number of inbred mouse strains. Initially, we sequenced approximately 6.7 kb of the Tas1r3 gene and its flanking regions from six inbred mouse strains with high and low saccharin preference, including the strains in which the Sac alleles were described originally (C57BL/6J, Sac(b); DBA/2J, Sac(d)). Of the 89 sequence variants detected among these six strains, eight polymorphic sites were significantly associated with preferences for 1.6 mm saccharin. Next, each of these eight variant sites were genotyped in 24 additional mouse strains. Analysis of the genotype-phenotype associations in all 30 strains showed the strongest association with saccharin preference at three sites: nucleotide (nt) -791 (3 bp insertion/deletion), nt +135 (Ser45Ser), and nt +179 (Ile60Thr). We measured Tas1r3 gene expression, transcript size, and T1R3 immunoreactivity in the taste tissue of two inbred mouse strains with different Tas1r3 haplotypes and saccharin preferences. The results of these experiments suggest that the polymorphisms associated with saccharin preference do not act by blocking gene expression, changing alternative splicing, or interfering with protein translation in taste tissue. The amino acid substitution (Ile60Thr) may influence the ability of the protein to form dimers or bind sweeteners. Here, we present data for future studies directed to experimentally confirm the function of these polymorphisms and highlight some of the difficulties of identifying specific DNA sequence variants that underlie quantitative trait loci

ガン タイケンシャ エノ sat リョウホウ ニ ヨル シンリ シエン ノ コウカ ニ ツイテ

がん体験者の心理支援は難しいが、SAT療法が開発され短期間での介入効果が得られるようになった。そこで、本研究はがん体験者にSAT療法を一斉に1回だけ用いることで、心理支援に効果があるか検討することとした。介入は、筆頭筆者が20xx年8月にがん体験者7人とその家族4人に対して、SAT療法で実施した。分析対象者はがん体験者6人(平均年齢:59.7±3.7歳、原発がんの発症年齢:55.8±5.8歳、原発がんの種類と人数:大腸がん1人、胃がん1人、乳がん2人、肺がん1人、子宮がん1人)であった。結果は、自己抑制型行動特性の値が介入前の5.0点から介入後の3.5点へと有意に改善した(z=-2.04,p= .04)。主観的ストレス度は介入前の30%から介入後の15%へと有意に改善した(z=-2.27,p= .02)。自己価値感尺度の値は介入前の8.0点から介入後の9.5点へと有意傾向で改善した。(z=-1.81,p= .07)。自己否定感尺度の値は有意差が得られなかったが、中央値・平均値はともに低下した。介入への自由記述は肯定的記述6人、否定的・中立的記述0人であった。これらのことから、がん体験という深刻なライフイベントに対して、一斉に1回だけのSAT療法による心理支援も一定の成果を得たといえる。PURPOSE: Providing psychological support for cancer experiencers is difficult. However, the intervention effect was attained in a short period of time after the development of the SAT therapy. Therefore, this research studied the effect on psychological support for cancer experiencers with the one-time use of the SAT therapy method en masse. DESIGN: Intervention was implemented by the authors using the SAT therapy on seven cancer experiencers and four family members in August 20xx. The subjects for the analysis included six cancer experiencers( average age: 59.7±3.7 years; age at the onset of the original cancer: 55.8±5.8 years; types of primary cancers and ages of subject: colon cancer: one person; stomach cancer: one person; breast cancer: two people; lung cancer: one person; uterine cancer: one person). RESULTS: The results showed significant improvement in characteristic values for self-repression from 5.0 points before intervention to 3.5 points after intervention. Subjective stress levels improved significantly from 30% before intervention to 15% after intervention. (z=2.27; p= .02) The scale values of self-esteem also showed a significant trend for improvement from 8.0 points before intervention to 9.5 points after intervention.( z=1.81; p=0.7) A significant difference was not attained for scale values for self-denial, but both the central value and average value dropped. In free descriptions relating to intervention, six people positively described intervention. No people expressed negative or neutral descriptions. CONCLUSION: In view of these results, some positive results were achieved in psychological support for the serious life event of experiencing cancer with only one use en masse of the SAT therapy

The invariance of asymptotic laws of stochastic systems under discretization

The stochastic trapezoidal rule provides the only discretization scheme from the family of implicit Euler methods (see [11]) which possesses the same asymptotic (stationary) law as underlying linear continuous time stochastic systems with white or coloured noise. This identity is shown for systems with multiplicative (para- metric) and additive noise using fixed point principles and the theory of positive operators. The key result is useful for adequate implementation of stochastic algorithms applied to numerical solution of autonomous stochastic differential equations. In particular it has practical importance when accurate long time integration is required such as in the process of estimation of Lyapunov exponents or stationary measures for oscillators in Mechanical Engineering

メンタルヘルス不調者へのセルフマネジメントプログラムの効果に関する研究

本研究の目的は、心療内科に通院するメンタルへルス不調者に、セルフマネジメントプログラムを用いた介入を行い、セルフマネジメント力を高める効果があるかを実証的に検証することである。方法は、「治療のみの変化」「介入による変化」「介入後の持続効果」を比較した群間比較研究である。対象は、うつ・不安障害などで心療内科に通院している患者10 名で、1 回2 時間、3 回からなるプログラムに参加し、その前後と1ヶ月後に質問紙調査を実施した。調査内容は、自己効力感、自己抑制型行動特性、問題解決型行動特性、抑うつ度とした。プログラム内容は、メンタルヘルス不調の心理教育、自己理解、イメージセラピー、エンカウンターグループで構成した。調査の結果、介入前後の比較において、自己抑制型行動特性、問題解決型行動特性に有意差は認められなかった。自己効力感（p＜0.5）、抑うつ（p＜0.1〉で有意な改善が認められた。また、自己効力感の下位因子であるネガティブ因子に有意傾向が認められた（p＜1）。これらの効果は介入1ヵ月後まで維持されていた。さらに、治療のみの期間における尺度の変化は認められなかったことから、介入前後の変化は介入による効果の可能性が高い。セルフマネジメントプログラム実施により、抑うつ気分の改善と自己効力認知の改善が認められ、セルフマネジメントに向けた効果が確認された。自己抑制型行動特性と問題解決型行動特性に変化は認められず、行動変容に至る期間を加味した長期的なフォローアップが必要である。一部の参加者の記述から気分と認知にセルフマネジメントに向けた肯定的な変化があり、統計的分析結果が参加者の主観からも裏付けられた。The purpose of this study is to empirically indicate whether intervention of patientswith mental health disorders, who regularly see doctors, with a self-management program is effective in improving their self-management capabilities.The method used was intergroup research comparing “change only by treatment”,“change by intervention”and“continuing effects after intervention”.Subjects were10patients who regularly saw psychosomatic doctors with the symptoms of depression,anxiety disorder, etc. The program was comprised of three2-hour sessions, and a questionnaire survey was taken before and after those sessions plus one month later.Survey contents included a feeling of self-efficacy,self-restraint behavioral characteristics, problem solving behavioral characteristics,and degree of depression.The program was comprised of psychoeducation of mental health disorders,self-understanding,image therapy, and encounter groups.The results did not show any significance in self-restraint behavioral characteristics or problem solving behavioral characteristics when comparing the before and after intervention, but significant improvement was confirmed on self-efficacy（p<0.5）and depression（p<0.1）.Additionally, a negativefactor, which is the hypostatic factor of self-efficacy, showed a tendency of marginal significance（p<1）.These effects remained1month after intervention. Since the scale didn’t change in the period of only receiving doctor’s treatment, it is highly possible that the intervention was responsible for the effective changes.Improvement in depression and recognition of self-efficacy from the intervention was recognized and the researchers confirmed its effect toward patients’self-management. Some of the written answers from participants stated they had positive changes in their mood and cognition,which confirmed the results of the statistical analysis from the participants’subjective viewpoint

「緩和ケアを推進する看護師教育プログラム」の評価 : 修了者およびその上司への調査から

京都府立医科大学医学部看護学科京都府立医科大学附属病院看護部京都府立医科大学看護実践キャリア開発センター京都府立医科大学附属病院地域医療推進部School of Nursing, Kyoto Prefectural University of MedicineDepartment of Nursing, University Hospital Kyoto Prefectural University of MedicineKyoto Prefectural University of Medicine, Career Development Center for NursingPromotion Division of Regional Medicine, University Hospital Kyoto Prefectural University of Medicine　本研究の目的は、「緩和ケア実践看護師養成コース（以下Aコース）」「在宅緩和ケア推進看護師養成コース（以下Bコース）」を受講した修了者とその上司への調査からプログラム評価および看護実践への活用状況を指標にしてプログラムを評価することである。【方法】平成27～31年度の間に京都府立医科大学看護実践キャリア開発センターが開催する「緩和ケアを推進する看護師教育プログラム」のAコースまたはBコースを受講した修了者25名のうち、調査時点で受講時と同じ施設・病院で就労を継続している21名（Aコース14名、Bコース7名）、とその上司21名（Aコース14名、Bコース7名）を研究対象者とした。修了生の施設・病院に質問紙を郵送し、令和3年7月～8月に無記名の自記式質問紙調査を行った。調査項目は、基本属性、カリキュラムについて、教育目標について、受講内容の適切性について、学習内容の臨床での活用について、とした。なお所属する大学の医学倫理審査委員会の承認を得て実施した（ERB-E-444）。【結果】回答者は、Aコース修了者9名、Aコース上司7名、Bコース修了者5名、Bコース上司3名であった。受講した修了者の評価においては、プログラムの内容についてAコースの8割以上が、Bコースの全員が（とても・まあまあ）適切としている。自己能力の発揮状況について、Aコースは4～6割、Bコースについては4～8割ができているとしている。　上司からの評価では、両コースとも受講した講義・演習・実習が7割程度現在の看護実践に役立っていると答えた。期待される能力については両コースとも8割以上が現在の看護活動に活きていると答えた。【結論】平成27年度から開始された「緩和ケアを推進する看護師教育プログラム」に対して、受講した修了者とその上司に，研修が有用であったかを問うたところ、受講した修了者はプログラムの内容が看護の実践で活かされていると実感していることが明らかとなった。さらに、上司は、受講した修了者が研修を踏まえた看護実践ができていると評価していることが明らかになった。修了者、上司の評価からプログラムの効果を評価することができた

Synthesis of a Novel Cysteine-Incorporated Anthraquinone Derivative and Its Structural Properties

A novel cysteine-incorporated anthraquinone derivative was synthesized, and its molecular structure was determined by X-ray crystal analysis. Each mercapto group was located separately and did not form a disulfide bond, and hydrogen bondings and π-π interaction were observed from the packing structure