Quantitative proteomics of plasma vesicles identify novel biomarkers for Hemoglobin E/ β-Thalassemic patients

Key PointsChaperones, antioxidants, iron-sequestering proteins, and cathepsin S exhibited increased abundance in thalassemic EVs. Haptoglobin and hemopexin are reduced in thalassemic patients’ EVs, reflecting hemolysis. These could be used as clinical biomarkers.</jats:p