Book Reviews

A History of Archival Practice. Paul Delsalle. Translated and revised by Margaret Procter. Archival Arrangement and Description: Analog to Digital. Lois Hamill. Participatory Heritage. Andrea Copeland and Henriette Roued-Cunliffe. Managing Local Government Archives. John H. Slate and Kaye Lanning Minchew. Archiving Websites: A Practical Guide for Information Management Professionals. Adrian Brown

Book Reviews

Book Review

Endocrine therapy resistant ESR1 variants revealed by genomic characterization of breast cancer derived xenografts

To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation

Endocrine-Therapy-Resistant ESR1 Variants Revealed by Genomic Characterization of Breast-Cancer-Derived Xenografts

To characterize patient-derived xenografts (PDXs) for functional studies, we made whole-genome comparisons with originating breast cancers representative of the major intrinsic subtypes. Structural and copy number aberrations were found to be retained with high fidelity. However, at the single-nucleotide level, variable numbers of PDX-specific somatic events were documented, although they were only rarely functionally significant. Variant allele frequencies were often preserved in the PDXs, demonstrating that clonal representation can be transplantable. Estrogen-receptor-positive PDXs were associated with ESR1 ligand-binding-domain mutations, gene amplification, or an ESR1/YAP1 translocation. These events produced different endocrine-therapy-response phenotypes in human, cell line, and PDX endocrine-response studies. Hence, deeply sequenced PDX models are an important resource for the search for genome-forward treatment options and capture endocrine-drug-resistance etiologies that are not observed in standard cell lines. The originating tumor genome provides a benchmark for assessing genetic drift and clonal representation after transplantation

Engaging with Silences: Clayton State Master of Archival Studies Program's Approach to Teaching

This paper will discuss the theoretical framework and approach to educating archivists in the Clayton State Master of Archival Studies (MAS) program. The MAS program is an entirely online program based in the state of Georgia in the U.S. Across the curriculum of the MAS, we approached developing our curriculum to ensure that students engage with social justice issues through wrestling with archival silences. Through creating a theoretical framework, class discussion activities, and assignments, our hope is for our students to be prepared to engage with issues of representation in archival collections once they are in the field. This paper explains the basis for our approach and provides example assignments which other institutions can use as inspiration for their archival education curriculum. For many, archival education emphasizes fundamentals. Archival educators and professionals seem most concerned with educating new archivists on topics such as how to preserve materials, how to provide access, and how to acquire materials. These activities are the work of archivists, but emphasis on the technical disguises the complexities of cultural, economic, and social issues that surround archival work. Technical archival work often silences the voices of many groups found within our collections through emphasizing standardization and mechanics of archival work. Student archivists need exposure to discussions that go beyond the technical. The MAS program does this by encouraging students to engage with the silences that occur during our work

SAASC Presents Joshua Kitchens from the Academy of Certified Archivists (ACA)

SAASC hosted Joshua Kitchens, Academy of Certified Archivists (ACA) regent, for a discussion on what it means to be a certified archivist and how best to prepare for the exam. This was followed by an informative Q & A session.https://scholarworks.sjsu.edu/saasc_events/1035/thumbnail.jp

Polychlorinated Biphenyls and Chlorinated Pesticides Concentrations in Fish from Kentucky Lake.

Polychlorinated biphenyls (PCBs) and chlorinated pesticides are well known environmental pollutants and responsible for serious environmental and health problems. One of the major routes of human exposure to PCBs and chlorinated pesticides is consumption of contaminated fish. The purpose of this study is to measure the levels of PCBs and chlorinated pesticides in Kentucky Lake fish. Several species of fish were collected from selected locations in the Kentucky Lake. The samples were dissected and only edible flesh portions were analyzed for PCB congeners and selected chlorinated pesticides. Standard analytical procedures were followed to measure the compounds in fish. In general, total PCB concentrations in fish fillet were relatively higher than the pesticides. Total PCB concentrations in Kentucky Lake fish ranged from 1.6 ng/g wet weight to 73 ng/g wet weight. Chlorinated pesticide concentration in fish ranged from 1.14 ng/g wet weight to 3.3 ng/g wet weight. The levels of PCBs and chlorinated pesticides in Kentucky Lake fish were below the Food and Drug Administrations established limits for human consumption