18 research outputs found
津波避難におけるジェンダーの影響:東日本大震災コミュニティ・アーカイブの災害記録をもとにした研究
Tohoku University小野田泰明課
Trastuzumab タンザイ リョウホウ ガ チョコウ シタ セツジョ フノウ シンコウ イガン ノ 1レイ
Trastuzumab, a humanized monoclonal antibody directed against human epidermal growth factor receptor2 (HER2), has been shown to be active against metastatic gastric cancer that overexpress HER2. A 78-year-old man presented with an edema in the lower legs. He was diagnosed as having advanced gastric cancers with multiple liver metastases in our hospital. Immunohistochemistry of the tumor cells revealed HER2 overexpression with an intensity of 3+. The patient was treated with DS-T chemotherapy (Docetaxel+S‐1+Trastuzumab) because of the presence of renal dysfunction. Due to the adverse effect appeared with his skin, DS-T chemotherapy has been canceled and trastuzumab chemotherapy was continued. After 11 months of trastuzumab monotherapy, metastatic liver tumors were diminished. There is very few report of a positive response to trastuzumab in a patient with HER2‐overexpressing metastatic gastric cancer