From both sides now: Crossover effects influence navigation in patients with unilateral neglect

Unilateral neglect is a challenging disorder that pervades a range of behaviours following stroke and hampers recovery. Although a preponderance of clinical studies measure performance on a range of bedside assessments, including line bisection and cancellation tasks, there have been calls for studies to embrace more relevant functional measures. Here, for the first time, we present data from two separate tasks that characterise the performance of seven patients with unilateral neglect when navigating a power wheelchair. The tasks involved negotiating an obstacle course and steering a central path between gaps of different sizes. Results from the obstacle course confirmed the clinical observation and predicted bias of contralesional errors. However, the second task revealed a robust "crossover" effect. Patients deviated to the ipsilesional side for large gaps but deviated increasingly contralesionally when steering through small gaps in behaviour that was analogous to that previously shown on line bisection tasks. Contrary to being seen as an unintuitive finding, further analysis of these errors suggests that patients are giving disproportionate weight to the location of the ipsilesional object when plotting a midline course between two objects. Our results provide a platform for further studies to investigate the modulation and rehabilitation of this important skill

Forward particle productions at RHIC and the LHC from CGC within local rcBK evolution

In order to describe forward hadron productions in high-energy nuclear collisions, we propose a Monte-Carlo implementation of Dumitru-Hayashigaki-Jalilian-Marian formula with the unintegrated gluon distribution obtained numerically from the running-coupling BK equation. We discuss influence of initial conditions for the BK equation by comparing a model constrained by global fit of small-x HERA data and a newly proposed one from the running coupling MV model.Comment: Talk given at conference Quark Matter 2011, 4 page

Parton distributions in the virtual photon target up to NNLO in QCD

Parton distributions in the virtual photon target are investigated in perturbative QCD up to the next-to-next-to-leading order (NNLO). In the case $\Lambda^2 \ll P^2 \ll Q^2$, where $-Q^2$ ($-P^2$) is the mass squared of the probe (target) photon, parton distributions can be predicted completely up to the NNLO, but they are factorisation-scheme-dependent. We analyse parton distributions in two different factorisation schemes, namely $\bar{\rm MS}$ and ${\rm DIS}_{\gamma}$ schemes, and discuss their scheme dependence. We show that the factorisation-scheme dependence is characterised by the large-$x$ behaviours of quark distributions. Gluon distribution is predicted to be very small in absolute value except in the small-$x$ region.Comment: 28 pages, 5 figures, version to appear in Eur. Phys. J.

Neuropsychological evidence for an interaction between endogenous visual and motor-based attention.

We report data examining the relations between endogenous allocation of visual attention and effects of motor-preparation on attention. We tested a patient with a spatial bias in perceptual report following damage to the left inferior parietal lobe and superior temporal gyrus. Previously we have shown that the spatial bias in report can be reduced when a movement is planned to where a target falls in the contralesional field, while the bias is exacerbated when a movement is planned to the ipsilesional side (Kitadono and Humphreys, 2007, Cognitive Neuropsychology, 24). Here we pitted the effects of planning a movement to the contra- or ipsilesional side against the effects of endogenous visual attention, manipulated by varying the probability of where a target would fall. In a no-movement baseline, there was better identification of contralesional targets when there was a good likelihood of targets appearing on the contralesional side (the 20-80 and 50-50 conditions) compared with when targets had a low probability of occurring there (the 80-20 condition). This sensitivity to target probability interacted with the effects of planning a movement to the contra- or ipsilesional side. When the target had a good probability of falling in the contralesional field (the 20-80 and 50-50 conditions), planning a movement to the ipsilesional side disrupted contralesional report. When there was a high probability of an ipsilesional target (the 80-20 condition), planning a movement to a congruent side improved contralesional report. The results indicate that effects of endogenous attention and of motor-based attention influence a common system controlling visual orienting

Short-term effects of the 'rubber hand' illusion on aspects of visual neglect.

The 'rubber hand' illusion was induced in a patient showing unilateral visual neglect, with the patient experiencing a shift in the felt position of his right hand towards a contralesional rubber hand. Immediately following the illusion, there were short- lasting reductions in neglect for bisecting about the midline and for cancelling multiple stimuli. No effects were found on the ability to encode briefly presented visual stimuli on the contralesional side. The data demonstrate that the illusion can temporarily alter some aspects of neglect, without altering basic visual encoding. The underlying mechanisms, and the relations to other rehabilitation procedures, are discussed

Interactions between perception and action programming: evidence from visual extinction and optic ataxia.

We report a series of 7 experiments examining the interaction between visual perception and action programming, contrasting 2 neuropsychological cases: a case of visual extinction and a case with extinction and optic ataxia. The patients had to make pointing responses to left and right locations, whilst identifying briefly presented shapes. Different patterns of performance emerged with the two cases. The patient with "pure" extinction (i.e., extinction without optic ataxia) showed dramatic effects of action programming on perceptual report. Programming an action to the ipsilesional side increased extinction (on 2-item trials) and tended to induce neglect (on 1-item trials); this was ameliorated when the action was programmed to the contralesional side. Separable effects of using the contralesional hand and pointing to the contralesional side were apparent. In contrast, the optic ataxic patient showed few effects of congruency between the visual stimulus and the action, but extinction when an action was programmed. This effect was particularly marked when actions had to be made to peripheral locations, suggesting that it reflected reduced resources to stimuli. These effects all occurred using stimulus exposures that were completed well before actions were effected. The data demonstrate interactions between action programming and visual perception. Programming an action to the affected side with the contralesional limb reduces "pure" extinction because attention is coupled to the end point of the action. However, in a patient with deficient visuo-motor coupling (optic ataxia), programming an action can increase a spatial deficit by recruiting resources away from perceptual processing. The implications for models of perception and action are discussed

Sustained interactions between perception and action in visual extinction and neglect: evidence from sequential pointing.

Interactions between perception and action were examined by assessing the effects of action programming on extinction and neglect. In an extension of prior work, effects of sequential motor programming were assessed under conditions in which attention was first directed to an ipsilesional stimulus. Despite pointing and reporting a stimulus on the ipsilesional side first, programming a second action to the contralesional side reduced the spatial deficit on report, improving the report of contralesional stimuli (relative to when the patient just pointed to the ipsilesional side) while decreasing the report of ipsilesional items. The data suggest that perception and action interact through motor feedback to early visual coding, helping a patient overcome a lack of visual awareness to contralesional stimuli. This is effective even when attention has to be disengaged from the ipsilesional side suggesting that motor programming decreases ipsilesional capture and exerts a sustained influence on perception

The interaction of attention and action: from seeing action to acting on perception.

We discuss evidence indicating that human visual attention is strongly modulated by the potential of objects for action. The possibility of action between multiple objects enables the objects to be attended as a single group, and the fit between individual objects in a group and the action that can be performed influences responses to group members. In addition, having a goal state to perform a particular action affects the stimuli that are selected along with the features and area of space that is attended. These effects of action may reflect statistical learning between environmental cues that are linked by action and/or the coupling between perception and action systems in the brain. The data support the argument that visual selection is a flexible process that emerges as a need to prioritize objects for action

The interaction of attention and action: From seeing action to acting on perception

We discuss evidence indicating that human visual attention is strongly modulated by the potential of objects for action. The possibility of action between multiple objects enables the objects to be attended as a single group, and the fit between individual objects in a group and the action that can be performed influences responses to group members. In addition, having a goal state to perform a particular action affects the stimuli that are selected along with the features and area of space that is attended. These effects of action may reflect statistical learning between environmental cues that are linked by action and/or the coupling between perception and action systems in the brain. The data support the argument that visual selection is a flexible process that emerges as a need to prioritize objects for action. © The British Psychological Society

Attention and its coupling to action

We discuss two commentaries that we have received on our target article (Humphreys et al., 2010). We elaborate on the evidence for action effects on extinction and discuss whether these effects occur pre or post the selection of a response. In addition, we discuss the neural basis of the effects of action relations on extinction and on the generalization of results on action relations to real-world examples