Impact of Heterogeneity of Human Peripheral Blood Monocyte Subsets on Myocardial Salvage in Patients With Primary Acute Myocardial Infarction

ObjectivesWe examined whether distinct monocyte subsets contribute in specific ways to myocardial salvage in patients with acute myocardial infarction (AMI).BackgroundRecent studies have shown that monocytes in human peripheral blood are heterogeneous.MethodsWe studied 36 patients with primary AMI. Peripheral blood sampling was performed 1, 2, 3, 4, 5, 8, and 12 days after AMI onset. Two monocyte subsets (CD14+CD16−and CD14+CD16+) were measured by flow cytometry. The extent of myocardial salvage 7 days after AMI was evaluated by cardiovascular magnetic resonance imaging as the difference between myocardium at risk (T2-weighted hyperintense lesion) and myocardial necrosis (delayed gadolinium enhancement). Cardiovascular magnetic resonance imaging was also performed 6 months after AMI.ResultsCirculating CD14+CD16−and CD14+CD16+monocytes increased in AMI patients, peaking on days 3 and 5 after onset, respectively. Importantly, the peak levels of CD14+CD16−monocytes, but not those of CD14+CD16+monocytes, were significantly negatively associated with the extent of myocardial salvage. We also found that the peak levels of CD14+CD16−monocytes, but not those of CD14+CD16+monocytes, were negatively correlated with recovery of left ventricular ejection fraction 6 months after infarction.ConclusionsThe peak levels of CD14+CD16−monocytes affect both the extent of myocardial salvage and the recovery of left ventricular function after AMI, indicating that the manipulation of monocyte heterogeneity could be a novel therapeutic target for salvaging ischemic damage

Snow and rainfall calculations over the Altai mountains area using the weather research and forecasting model, WRF

第2回極域科学シンポジウム/第34回気水圏シンポジウム 11月15日（火） 統計数理研究所 セミナー室

VECTORIZING THE COMMUNITY LAND MODEL

In this paper we describe our extensive efforts to rewrite the Community Land Model (CLM) so that it provides good vector performance on the Earth Simulator in Japan and the Cray X1 at Oak Ridge National Laboratory. We present the technical details of the old and new internal data structures, the required code reorganization, and the resulting performance improvements. We describe and compare the performance and scaling of the final CLM Version 3.0 (CLM3.0) on the IBM Power4, the Earth Simulator, and the Cray X1. At 64 processors, the performance of the model is similar on the IBM Power4, the Earth Simulator, and the Cray X1. However, the Cray X1 offers the best performance of all three platforms tested from 4 to 64 processors when OpenMP is used. Moreover, at low processor counts (16 or fewer), the model performs significantly better on the Cray X1 than on the other platforms. The vectorized version of CLM was publicly released by the National Center for Atmospheric Research as the standalone CLM3.0, as a part of the new Community Atmosphere Model Version 3.0 (CAM3.0), and as a componen

Adventures in Vectorizing the Community Land Model

Described here are the extensive efforts of the authors to modify the Community Land Model for vectorization on the Earth Simulator in Japan and the Cray X1 at Oak Ridge National Laboratory. This paper follows experimental results presented at the Cray Users Group (CUG) Meeting in 2003 (White, 2003). Presented here are the technical details of the old and new internal data structures, the required code reorganization, and the resulting performance improvements. Additionally, performance and scaling of the final Community Land Model Version 3 (CLM3) on the IBM Power4, the Earth Simulator, and the Cray X1 are compared.