ガンセイ キョウマクエン カンジャ ニオケル OK-432 キョウクウ ナイ トウヨ ジ ノ ギョウコケイ ニ カンスル ケンキュウ : Fibrinogen チ ト キョウマク ユチャク トノ カンケイ

胸膜炎における胸膜癒着と, 血漿Fbg上昇との関係を明らかにする目的で, 癌性胸膜炎のOK-432胸腔内注入治療を行なった例を対象として下記の成績を得た。1.胸膜癒着像を残し, 2ヶ月間以上再貯留を認めなかった例(有効例)で, OK-432注入後血漿Fbg値は全例上昇し, 胸水中Fbg値は80%に上昇した。胸水Fbg値は血漿Fbg値より低値を示した。2.無効例では血漿および胸水Fbg値は注入後上昇は認められなかった。The effect of intrapleurally administered OK-432 on plasma on fibrinogen levels in cases with pleuritis carcinomatosa was examined. Plasma fibrinogen level was examined as a predictive index of pleural adhesion in cancerous pleuritis. Twelve cases with pleural effusion due to cancerous pleuritis were studied. Ten of 12 patients given OK-432 showed no accumulation of pleural fluid for 2 months and persistent pleural adhesion (effective). Eight cases showed a marked increase in plasma fibrinogen levels after OK-432 administration, while 8 showed a slight increase in fibrinogen levels in the pleural fluid. The 2 cases in whom no effect of OK-432 was recognized showed no significant change in fibrinogen level either in plasma or in the pleural fluid. The above mentioned findings revealed that elevated plasma fibrinogen level is a useful index to predict pleural adhesion in patients with inflammatory pleuritis