The Fluorescent Probing Method in the Estimation of the Functional Probabilities of the Blood Plasma Transport Systems

During this work method of fluorescent probes with differently charged fluorescent dyes was used for estimation of binding ability of the blood plasma main transport proteins. Investigations were done at the patients with liver cirrhosis for creating on those basis fluorescent tests adapted for clinical use. Such tests should use for depending of severity degree of pathological process and for the correct choice of the most effective haemosorbent for extracorporeal blood purification in the definite clinical situation. Regularity was shown for the changes in the binding ability of the blood plasma main transport proteins in liver cirrhosis, which depended on the stage of the disease and allowed efficiently estimate severity degree of pathological process. Comparative evaluation of the efficacy of different charcoal haemosorbents widely used in clinical practice as well as "Prometheus" device was done in terms of endogenous intoxication syndrome correction at liver cirrhosis patients using results of biochemical analysis and method of fluorescent dyes. It was shown that the most effective sorbents were sorbents of "Prometheus" and between charcoal heamosorbents - "Carbocol"

The Fluorescent Probing Method in the Estimation of the Functional Probabilities of the Blood Plasma Transport Systems

During this work method of fluorescent probes with differently charged fluorescent dyes was used for estimation of binding ability of the blood plasma main transport proteins. Investigations were done at the patients with liver cirrhosis for creating on those basis fluorescent tests adapted for clinical use. Such tests should use for depending of severity degree of pathological process and for the correct choice of the most effective haemosorbent for extracorporeal blood purification in the definite clinical situation. Regularity was shown for the changes in the binding ability of the blood plasma main transport proteins in liver cirrhosis, which depended on the stage of the disease and allowed efficiently estimate severity degree of pathological process. Comparative evaluation of the efficacy of different charcoal haemosorbents widely used in clinical practice as well as "Prometheus" device was done in terms of endogenous intoxication syndrome correction at liver cirrhosis patients using results of biochemical analysis and method of fluorescent dyes. It was shown that the most effective sorbents were sorbents of "Prometheus" and between charcoal heamosorbents - "Carbocol"

EVALUATION OF THE FUNCTIONAL PROBABILITIES OF THE BLOOD PLASMA TRANSPORT SYSTEMS OF THE LIVER CIRRHOSIS PATIENTS BY THE FLUORESCENT PROBES METHOD AND ASSESSING OF HYDROPHOBIC SUBSTANCES ELIMINATION AFTER HEMOSORPTION AT THESE PATIENTS

The results of investigation of the main blood plasma transport proteins binding ability at liver cirrhosis patients by the fluorescent probes method are presented. It is shown that fluorescent probes method allows to get express information about functional state of the main blood plasma transport proteins at liver cirrhosis patients, promptly assess the disease severity, and according to this information change their treatment quickly

ОЦЕНКА ФУНКЦИОНАЛЬНЫХ ВОЗМОЖНОСТЕЙ ТРАНСПОРТНОЙ СИСТЕМЫ ПЛАЗМЫ КРОВИ У ПАЦИЕНТОВ С ЦИРРОЗОМ ПЕЧЕНИ МЕТОДОМ ФЛУОРЕСЦЕНТНОГО ЗОНДИРОВАНИЯ И ЭЛИМИНАЦИИ ГИДРОФОБНЫХ СУБСТАНЦИИ ПРИ ПРОВЕДЕНИИ ИМ ГЕМОСОРБЦИИ

The results of investigation of the main blood plasma transport proteins binding ability at liver cirrhosis patients by the fluorescent probes method are presented. It is shown that fluorescent probes method allows to get express information about functional state of the main blood plasma transport proteins at liver cirrhosis patients, promptly assess the disease severity, and according to this information change their treatment quickly.Приведены результаты исследования связывающей способности основных транспортных белков плазмы крови пациентов с циррозом печени методом флуоресцентного зондирования. Показано, что данный метод позволяет получать экспресс информацию о функциональном состоянии основных транспортных систем плазмы крови пациентов

Evaluation of the functional probabilities of the blood plasma transport systems of the liver cirrhosis patients by the fluorescent probes method and assessing of hydrophobic substances elimination after hemosorption at these patients

Приведены результаты исследования связывающей способности основных транспортных белков плазмы крови пациентов с циррозом печени методом флуоресцентного зондирования. Показано, что данный метод позволяет получать экспресс информацию о функциональном состоянии основных транспортных систем плазмы крови пациентов. The results of investigation of the main blood plasma transport proteins binding ability at liver cirrhosis patients by the fluorescent probes method are presented. It is shown that fluorescent probes method allows to get express information about functional state of the main blood plasma transport proteins at liver cirrhosis patients, promptly assess the disease severity, and according to this information change their treatment quickly

Evaluation of the functional probabilities of the blood plasma transport systems of the liver cirrhosis patients by the fluorescent probes method and assessing of hydrophobic substances elimination after hemosorption at these patients

Приведены результаты исследования связывающей способности основных транспортных белков плазмы крови пациентов с циррозом печени методом флуоресцентного зондирования. Показано, что данный метод позволяет получать экспресс информацию о функциональном состоянии основных транспортных систем плазмы крови пациентов. The results of investigation of the main blood plasma transport proteins binding ability at liver cirrhosis patients by the fluorescent probes method are presented. It is shown that fluorescent probes method allows to get express information about functional state of the main blood plasma transport proteins at liver cirrhosis patients, promptly assess the disease severity, and according to this information change their treatment quickly