Polyamine uptake in the malaria parasite, Plasmodium falciparum, is dependent on the parasite's membrane potential

Polyamines are present at high levels in proliferating cells, including cancerous cells and protozoan parasites and the inhibition of their synthesis has been exploited in antiproliferative strategies. Inhibition of the malaria parasite’s polyamine biosynthetic pathway causes cytostatic arrest in the trophozoite stage but does not cure in vivo infections in the murine model of malaria. This is possibly due to exogenous polyamine salvage from the host, which replenishes the intracellular polyamine pool. This implies that disruption of polyamine metabolism as an antimalarial chemotherapy strategy may require targeting both polyamine biosynthesis and transport simultaneously

Spontaneous emergence of spatial patterns ina a predator-prey model

We present studies for an individual based model of three interacting populations whose individuals are mobile in a 2D-lattice. We focus on the pattern formation in the spatial distributions of the populations. Also relevant is the relationship between pattern formation and features of the populations' time series. Our model displays travelling waves solutions, clustering and uniform distributions, all related to the parameters values. We also observed that the regeneration rate, the parameter associated to the primary level of trophic chain, the plants, regulated the presence of predators, as well as the type of spatial configuration.Comment: 17 pages and 15 figure

A variational problem on Stiefel manifolds

In their paper on discrete analogues of some classical systems such as the rigid body and the geodesic flow on an ellipsoid, Moser and Veselov introduced their analysis in the general context of flows on Stiefel manifolds. We consider here a general class of continuous time, quadratic cost, optimal control problems on Stiefel manifolds, which in the extreme dimensions again yield these classical physical geodesic flows. We have already shown that this optimal control setting gives a new symmetric representation of the rigid body flow and in this paper we extend this representation to the geodesic flow on the ellipsoid and the more general Stiefel manifold case. The metric we choose on the Stiefel manifolds is the same as that used in the symmetric representation of the rigid body flow and that used by Moser and Veselov. In the extreme cases of the ellipsoid and the rigid body, the geodesic flows are known to be integrable. We obtain the extremal flows using both variational and optimal control approaches and elucidate the structure of the flows on general Stiefel manifolds.Comment: 30 page

Multivalued SK-contractions with respect to b-generalized pseudodistances

A new class of multivalued non-self-mappings, called SK-contractions with respect to b-generalized pseudodistances, is introduced and used to investigate the existence of best proximity points by using an appropriate geometric property. Some new fixed point results in b-metric spaces are also obtained. Examples are given to support the usability of our main result

Lepton Acceleration in Pulsar Wind Nebulae

Pulsar Wind Nebulae (PWNe) act as calorimeters for the relativistic pair winds emanating from within the pulsar light cylinder. Their radiative dissipation in various wavebands is significantly different from that of their pulsar central engines: the broadband spectra of PWNe possess characteristics distinct from those of pulsars, thereby demanding a site of lepton acceleration remote from the pulsar magnetosphere. A principal candidate for this locale is the pulsar wind termination shock, a putatively highly-oblique, ultra-relativistic MHD discontinuity. This paper summarizes key characteristics of relativistic shock acceleration germane to PWNe, using predominantly Monte Carlo simulation techniques that compare well with semi-analytic solutions of the diffusion-convection equation. The array of potential spectral indices for the pair distribution function is explored, defining how these depend critically on the parameters of the turbulent plasma in the shock environs. Injection efficiencies into the acceleration process are also addressed. Informative constraints on the frequency of particle scattering and the level of field turbulence are identified using the multiwavelength observations of selected PWNe. These suggest that the termination shock can be comfortably invoked as a principal injector of energetic leptons into PWNe without resorting to unrealistic properties for the shock layer turbulence or MHD structure.Comment: 19 pages, 5 figures, invited review to appear in Proc. of the inaugural ICREA Workshop on "The High-Energy Emission from Pulsars and their Systems" (2010), eds. N. Rea and D. Torres, (Springer Astrophysics and Space Science series

Current Star Formation in the Perseus Molecular Cloud: Constraints from Unbiased Submillimeter and Mid-Infrared Surveys

We present a census of the population of deeply embedded young stellar objects (YSOs) in the Perseus molecular cloud complex based on a combination of Spitzer Space Telescope mid-IR data from the c2d legacy team and JCMT/SCUBA submillimeter maps from the COMPLETE team. The mid-IR sources detected at 24 micron and having [3.6]-[4.5] > 1 are located close to the center of the SCUBA cores, typically within 15" of their peaks. The narrowness of the spatial distribution of mid-IR sources around the peaks of the SCUBA cores suggests that no significant dispersal of the newly formed YSOs has occurred. This argues against the suggestion that motions of protostars regulate the time scales over which significant (Bondi-Hoyle) accretion can occur. The most deeply embedded YSOs are found in regions with high extinction, AV > 5, similar to the extinction threshold observed for the SCUBA cores. All the SCUBA cores with high concentrations have embedded YSOs, but not all cores with low concentrations are starless. An unbiased sample of 49 deeply embedded YSOs is constructed. Embedded YSOs are found in 40 of the 72 SCUBA cores with only three cores harboring multiple embedded YSOs within 15". The equal number of SCUBA cores with and without embedded YSOs suggests that the time scale for the evolution through the dense prestellar stages, where the cores are recognized in the submillimeter maps and have central densities of 5e4-1e5 cm^{-3}, is similar to the time scale for the embedded protostellar stages. The current star formation efficiency of cores is estimated to be approximately 10-15%. In contrast, the star formation efficiency averaged over the cloud life time and compared to the total cloud mass is only a few percent, reflecting also the efficiency in assembling cloud material into the dense cores forming stars.Comment: Accepted for publication in ApJ (36 pages, 13 figures