Is heart rate variability a valuable method to investigate cardiac autonomic dysfunction in subjects with leukemia? A systematic review to evaluate its importance in clinical practice

Impaired cardiovascular and autonomic function during treatment and during recovery from leukemia has been indicated. In this context, heart rate variability (HRV) is a non-invasive measure that describes the oscillations of the intervals between consecutive heart beats (RR intervals), influenced by the autonomic nervous system. We intend to review literature showing HRV changes in leukemia subjects. The articles selected in the current review were attained up to March 2018, and the search was limited to articles in English language, published in peer-reviewed journals, with both adult and child age samples. The articles were investigated in the five electronic databases: PubMed, Physiotherapy Evidence Database (PEDro), Cochrane Clinical Trials, Scientific Electronic Library Online (SciELO), and Excerpta Medica dataBASE (EMBASE). Towards the end of the research, 9 studies were included. Subjects undergoing treatment for leukemia have reduced HRV, signifying decreased vagal control of heart rate. The subjects that undertook leukemia treatment and their survivors experienced a reduction in HRV with subsequent recovery, but the recovery time is ill defined. HRV is reduced in leukemia subjects who progress to neuropathy secondary to chemotherapy, accompanied by cardiac dysfunction. We advocate the use of HRV to evaluate autonomic function and decide the treatment to prevent autonomic impairment in leukemia subjects

Impact of respiratory physical therapy on heart rate autonomic control in children with leukemia

Introduction. Considering that heart rate (HR) autonomic control is impaired in cancer and subsequent respiratory effort may overload the heart, we aimed to evaluate the effect of a respiratory physical therapy session on HR autonomic regulation in children with leukemia so as to confirm its safety. Methods. We selected children with leukemia (n = 10) and healthy children (n = 11), which were submitted to a session of respiratory physical therapy. We used Spiron Kids (NCS, Brazil), Children’s Voldyne (HUDSON RCI, USA), and Shaker (NCS, Brazil) as respiratory devices. The respiratory exercise protocols were founded on three standardized protocols. HR variability (HRV) was analyzed before, in the first minute and 5 to 10 min after intervention. Results. We recognized no change between rest and recovery from intervention in HRV (rMSSD—square root mean square of the differences between adjacent normal R-R intervals)—Control: p = 0.8111, Leukemia: p = 0.1197, among groups: p = 0.6574; SD1—standard deviation from instantaneous beat-to-beat variability—Control: p = 0.8111, Leukemia: p = 0.131, among groups: p = 0.6556; 0V—with no variation (3 equal symbols, for example (2,2,2)—Control: p = 0.3679, Leukemia: p = 0.3553, among groups: p = 0.7421); 2UV—with two variations to the contrary (the three symbols form a peak or a valley, for instance (3,5,3)—Control: p = 0.3679, Leukemia: p = 0.2359, among groups: p = 0.4007). HF—high frequency component, range 0.15 to 0.4 Hz—decreased 0 to 1 min after intervention in the leukemia group (p = 0.0303) and no change was observed in the control group between rest versus recovery from intervention (p = 0.9761). No significant change was reported in HF between groups (p = 0.8700). Two leukemia subjects treated with vincristine presented different HRV responses to the intervention group. Conclusion. A respiratory physical therapy session did not significantly change autonomic control of HR in children with leukemia. Yet, clinicians should be mindful of subjects undergoing treatment with vincristine

SCREENING in MICE of SOME MEDICINAL-PLANTS USED for ANALGESIC PURPOSES in the STATE of SAO-PAULO .2.

ESCOLA PAULISTA MED SCH,DEPT FARMACOL,RUA BOTUCATU 862,BR-04023 São Paulo,SP,BRAZILINST BOT,BR-01057 São Paulo,BRAZILESCOLA PAULISTA MED SCH,DEPT FARMACOL,RUA BOTUCATU 862,BR-04023 São Paulo,SP,BRAZILWeb of Scienc