Quantum Regime of a Two-Dimensional Phonon Cavity

The quantum regime in acoustic systems is a focus of recent fundamental research in the new field of Quantum Acoustodynamics (QAD). Systems based on surface acoustic waves having an advantage of easy integration in two-dimensions are particularly promising for the demonstration of novel effects in QAD and development of novel devices of quantum acousto-electronics. We demonstrate the vacuum mode of the surface acoustic wave resonator by coupling it to a superconducting artificial atom. The artificial atom is implemented into the resonator formed by two Brag mirrors. The results are consistent with expectations supported by the system model and our calculations. This work opens the way to map analogues of quantum optical effects into acoustic systems

A phononic crystal coupled to a transmission line via an artificial atom

We study a phononic crystal interacting with an artificial atom { a superconducting quantum system { in the quantum regime. The phononic crystal is made of a long lattice of narrow metallic stripes on a quatz surface. The artificial atom in turn interacts with a transmission line therefore two degrees of freedom of different nature, acoustic and electromagnetic, are coupled with a single quantum object. A scattering spectrum of propagating electromagnetic waves on the artificial atom visualizes acoustic modes of the phononic crystal. We simulate the system and found quasinormal modes of our phononic crystal and their properties. The calculations are consistent with the experimentally found modes, which are fitted to the dispersion branches of the phononic crystal near the first Brillouin zone edge. Our geometry allows to realize effects of quantum acoustics on a simple and compact phononic crystal

The Rationale for the Optimal Continuous-Variable Quantum Key Distribution Protocol

This article describes the current technical level of developments in the field of continuous-variable quantum key distribution (CV-QKD). Various classifications are described, the criteria are analyzed, and the optimal protocol is selected. The analysis is focused around device-dependent schemes with a theoretical emphasis, and therefore, a detailed analysis of device-independent CV-QKD and side-channel attacks is out of the scope of the work. However, the latter, one way or another, is taken into account when describing possible classifications. The choice of the optimal protocol was carried out, first of all, from the potential possibility of integration into existing network telecommunication infrastructures. Predominantly, the general classification is carried out in such a way that it is possible to draw up a specific protocol, depending on the task of implementation

Development of DNA aptamers for visualization of glial brain tumors and detection of circulating tumor cells

Here, we present DNA aptamers capable of specific binding to glial tumor cells in vitro, ex vivo, and in vivo for visualization diagnostics of central nervous system tumors. We selected the aptamers binding specifically to the postoperative human glial primary tumors and not to the healthy brain cells and meningioma, using a modified process of systematic evolution of ligands by exponential enrichment to cells; sequenced and analyzed ssDNA pools using bioinformatic tools and identified the best aptamers by their binding abilities; determined three-dimensional structures of lead aptamers (Gli-55 and Gli-233) with small-angle X-ray scattering and molecular modeling; isolated and identified molecular target proteins of the aptamers by mass spectrometry; the potential binding sites of Gli-233 to the target protein and the role of post-translational modifications were verified by molecular dynamics simulations. The anti-glioma aptamers Gli-233 and Gli-55 were used to detect circulating tumor cells in liquid biopsies. These aptamers were used for in situ, ex vivo tissue staining, histopathological analyses, and fluorescence-guided tumor and PET/CT tumor visualization in mice with xenotransplanted human astrocytoma. The aptamers did not show in vivo toxicity in the preclinical animal study. This study demonstrates the potential applications of aptamers for precise diagnostics and fluorescence-guided surgery of brain tumors.peerReviewe