252 research outputs found
Quantum analogue of the spin-flop transition for a spin pair
Quantum (step-like) magnetization curves are studies for a spin pair with
antiferromagnetic coupling in the presence of a magnetic field parallel to the
easy axis of the magnetic anisotropy. The consideration is done both
analytically and numerically for a wide range of the anisotropy constants and
spins up to . Depending on the origin of the anisotropy
(exchange or single-ion), the magnetization curve can demonstrate the jumps
more than unity and the concentration of the unit jumps in a narrow range of
the field. We also point the region of the problem parameters, where the
behavior is quasiclassical for , and where system is substantially
quantum in the limit .Comment: 5 pages, 5 figure
Development of a High-Throughput Assay for Identifying Inhibitors of TBK1 and IKKε
IKKε and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified. While the substrate specificity of IKKε has recently been described, the substrate specificity of TBK1 is unknown, hindering the development of high-throughput screening technologies for inhibitor identification. Here, we describe the optimal substrate phosphorylation motif for TBK1, and show that it is identical to the phosphorylation motif previously described for IKKε. This information enabled the design of an optimal TBK1/IKKε substrate peptide amenable to high-throughput screening and we assayed a 6,006 compound library that included 4,727 kinase-focused compounds to discover in vitro inhibitors of TBK1 and IKKε. 227 compounds in this library inhibited TBK1 at a concentration of 10 µM, while 57 compounds inhibited IKKε. Together, these data describe a new high-throughput screening assay which will facilitate the discovery of small molecule TBK1/IKKε inhibitors possessing therapeutic potential for both inflammatory diseases and cancer
Innovation Performance and its Influence on Enterprise Economic Efficiency in the Market
Innovations are means of competition. A success in how an enterprise uses the innovation processes directly depends on its competitive ability and profitability level. Innovation performance is a level of using innovations. Under a competitive struggle in the market, progress in science and technology holds a specific place. Innovations define the economic success of an organization. It is not simple to have only a desire to increase the performance results, it is necessary to have a factor for organization survival, competitive ability and economic growth prospects preservation throughout the modern innovation world. The experience of the most developed countries shows that the one, whose activity is mainly based on using the innovation processes, becomes a winner in a fight for his client and the main purpose of organizations' strategic plan is to develop either a new product or services. The innovation performance of an enterprise can become one of the main factors for organizing the competitive strategic prospects of an enterprise, preserving and increasing its positions in the market. The topicality of the theme is very high, as introducing innovations in the activity of an enterprise and its competitive ability level in the market depend on the level of an organization's innovation performance.
Keywords: innovation, innovation performance
JEL Classifications: O14, O31, O32, O3
Distillate ethanol production for re-use of abandoned lands - an analysis and risk assessment
Properties of Neutral Charmed Mesons in Proton--Nucleus Interactions at 70 GeV
The results of treatment of data obtained in the SERP-E-184experiment
"Investigation of mechanisms of the production of charmed particles in
proton-nucleus interactions at 70 GeV and their decays" by irradiating the
active target of the SVD-2 facility consisting of carbon, silicon, and lead
plates, are presented. After separating a signal from the two-particle decay of
neutral charmed mesons and estimating the cross section for charm production at
a threshold energy {\sigma}(c\v{c})=7.1 \pm 2.4(stat.) \pm 1.4(syst.)
\mub/nucleon, some properties of D mesons are investigated. These include the
dependence of the cross section on the target mass number (its A dependence);
the behavior of the differential cross sections d{\sigma}/dpt2 and
d{\sigma}/dxF; and the dependence of the parameter {\alpha} on the kinematical
variables xF, pt2, and plab. The experimental results in question are compared
with predictions obtained on the basis of the FRITIOF7.02 code.Comment: 9 pages, 9 figures,3 table
New Method of Plague Agent Lipopolysaccharide Obtaining
Put forward are two alternatives of a new method for optimization of conditions of LPS obtaining and purification from Y. pestis strains; as well as for avoiding application of poisonous and hard-to-remove reagents; for simplification and cost-cutting of the technique; and for rationalization of production waste management. This method involves preliminary salt-water extraction of bacteria, for elimination of easy-dissolving substances, with the subsequent fracturing using ultrasound in lysing buffer (0,1 M Tris-HCl, pH 8,0; 10 mmol of EDTA, 1 % Triton X-100). The first alternative for deproteinization of non-purified endotoxin is the commercial preparation of proteinase K (Sigma), the second one - an enzyme complex - proteovibrin, isolated from waste material accumulated in the process of cholera chemical bivalent vaccine production. Apart from this, introduced has been a phase of sample acidification by applying glacial acetic acid up to pH 3,2-3,4 to decontaminate LPS from nucleic acids. These two variations of the method provide for enhancement of LPS preparation quality as compared to prototype method, and for obtainment of plague agent endotoxin that is hardly distinguishable in physical-chemical properties, homogeneity, immunochemical activity and specificity from the antigen, manufactured by means of water-phenol extraction following Westphal O. technique
Alternative approach to electromagnetic field quantization in nonlinear and inhomogeneous media
A simple approach is proposed for the quantization of the electromagnetic
field in nonlinear and inhomogeneous media. Given the dielectric function and
nonlinear susceptibilities, the Hamiltonian of the electromagnetic field is
determined completely by this quantization method. From Heisenberg's equations
we derive Maxwell's equations for the field operators. When the nonlinearity
goes to zero, this quantization method returns to the generalized canonical
quantization procedure for linear inhomogeneous media [Phys. Rev. A, 43, 467,
1991]. The explicit Hamiltonians for the second-order and third-order nonlinear
quasi-steady-state processes are obtained based on this quantization procedure.Comment: Corrections in references and introductio
- …