6 research outputs found

    A comparative study of circulating plasma lipid components and superoxide dismutase activity in pre and postmenopausal women

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    Background: Menopause is associated with increased oxidative stress and decreased antioxidative activity in females which leads to increased risk of cardiovascular and many other diseases. The objective was to compare the lipid profiles and superoxide dismutase (SOD) activity of pre and postmenopausal women in an attempt to establish the fact that menopause is associated with increased oxidative stress.Methods: A hospital based cross-sectional study was done at the department of obstetrics and gynaecology and biochemistry, Shri Mahant Indiresh Hospital, Dehradun, India. Out of total of 120 women, 60 women were in premenopausal group aged between 30-45 years and 60 women of 55-70 years of age group in post menopause status. Assessment of lipid profile was done by an automated chemistry analyzer (Vitors 5, I FS) and SOD activity was measured by colorimetric activity kit. Statistical analysis was done by Standard Microsoft Excel software.Results: Mean serum SOD level in premenopausal women was 4.80±1.73 U/ml and in postmenopausal was 1.35±0.58 U/ml. This variation was found to be extremely significant (p <0.0001). Changes in lipid components in pre and postmenopausal women showed that total cholesterol and triglycerides levels were higher in postmenopausal than premenopausal participants. These variations were also significant (p = 0.0003). Levels of HDL-C were lower in postmenopausal women than pre-menopausal group with a mean±SD of 51.5±12.20 mg/dl and 54.05±14.03mg/dl respectively.Conclusions: Findings of this study corroborate the hypothesis that gradual loss of ovarian function is associated with a decrease in antioxidant status. Menopause also leads to changes in lipid components, which can predispose women to cardiovascular diseases

    A comparative study of circulating plasma lipid components and superoxide dismutase activity in pre and postmenopausal women

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    Background: Menopause is associated with increased oxidative stress and decreased antioxidative activity in females which leads to increased risk of cardiovascular and many other diseases. The objective was to compare the lipid profiles and superoxide dismutase (SOD) activity of pre and postmenopausal women in an attempt to establish the fact that menopause is associated with increased oxidative stress.Methods: A hospital based cross-sectional study was done at the department of obstetrics and gynaecology and biochemistry, Shri Mahant Indiresh Hospital, Dehradun, India. Out of total of 120 women, 60 women were in premenopausal group aged between 30-45 years and 60 women of 55-70 years of age group in post menopause status. Assessment of lipid profile was done by an automated chemistry analyzer (Vitors 5, I FS) and SOD activity was measured by colorimetric activity kit. Statistical analysis was done by Standard Microsoft Excel software.Results: Mean serum SOD level in premenopausal women was 4.80±1.73 U/ml and in postmenopausal was 1.35±0.58 U/ml. This variation was found to be extremely significant (p &lt;0.0001). Changes in lipid components in pre and postmenopausal women showed that total cholesterol and triglycerides levels were higher in postmenopausal than premenopausal participants. These variations were also significant (p = 0.0003). Levels of HDL-C were lower in postmenopausal women than pre-menopausal group with a mean±SD of 51.5±12.20 mg/dl and 54.05±14.03mg/dl respectively.Conclusions: Findings of this study corroborate the hypothesis that gradual loss of ovarian function is associated with a decrease in antioxidant status. Menopause also leads to changes in lipid components, which can predispose women to cardiovascular diseases

    Facet Engineering by Sculpting Artificial Edges on 2D Black Phosphorus for Localized and Selective Piezoelectric Response

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    The ability to achieve orientation selectivity in piezoelectric response and thereby identifying its active piezoelectric facets with superior response is imperative for the breakthrough in piezoelectricity; still, it remains a challenge due to the presence of the mixed facets in contemporary semicrystalline piezoelectric materials. Accurate determination of in-plane and out-of-plane piezoelectric coefficients in these materials is practically impossible due to the involvement of components of other piezoelectric tensors arising from the randomly oriented molecules. This report delves into the exploration of the piezoelectric and ferroelectric response at piezoelectric facets such as basal plane and edges of two-dimensional (2D) black phosphorus (BP) flake and thereby measures the in-plane and out-of-plane piezoelectric coefficients in their pure form. In this report, the localized piezoelectric facets (artificial edges) are meticulously sculpted using a low-power focused laser, resulting in precise piezoelectric response selectivity at facets of the BP flake. The experimental findings, supported by theoretical calculations, demonstrate that the in-plane piezoelectric response is prominent at the edges, while the out-of-plane response is significant at the basal plane of the flakes. Moreover, thinner flakes exhibit lower coercive voltage (VC) and voltage at the spontaneous polarization (VS), indicating a stronger ferroelectric response as compared to thicker flakes. The experimental results offer an innovative path for deciphering the active piezoelectric coefficient along different crystal facets of 2D materials, offering exciting prospects for further research beyond the confinement of contemporary piezoelectric materials

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