12 research outputs found
Computer-aided methods for single stage fibrous dysplasia excision and reconstruction in the zygomatico-orbital complex
Computer Aided Design and Additive Manufacture (CAD/AM) technologies are sufficiently refined and meet
the necessary regulatory requirements for routine incorporation into the medical field, with long-standing
application in surgeries of the maxillofacial and craniofacial region. They have resulted in better medical care
for patients, and faster, more accurate procedures. Despite ever-growing evidence about the advantages of
computer aided planning, CAD and AM in surgery, detailed reporting on critical design decisions that enable
methodological replication, and the development and establishment of guidelines to ensure safety, are limited.
This paper presents a novel application of CAD and AM to a single stage resection and reconstruction of fibrous
dysplasia in the zygoma and orbit. It is reported in sufficient fidelity to permit methods replication and design
guideline developments in future cases, wherever they occur in the world. The collaborative approach included
engineers, designers, surgeons and prosthetists to design patient-specific cutting guides and a custom implant.
An iterative design process was used, until the desired shape and function were achieved, for both of the
devices. The surgery followed the CAD plan precisely and without problems. Immediate post-operative
subjective clinical judgements were of an excellent result.
At 19 months post-op, a CT scan was undertaken to verify the clinical and technical outcomes. Dimensional
analysis showed maximum deviation of 4.73 mm from the plan to the result, while CAD-Inspection showed that
the deviations range between -0.1 and -0.8 mm, and that the majority of deviations are located around the –0.3
mm.
Improvements are suggested and conclusions drawn regarding the design decisions considered critical to a
successful outcome for this type of procedure in the future
Application of the adsorbent CR-100 for Ammonium Removal: Thermodynamic and Kinetic Studies
Groundwater with increased ammonia concentration is a constant concern regarding the preparation of drinking water. The affinity of ammonia to be adsorbed on the surface of different solid materials significantly influences the selection of its removal process and has been the motivation for this investigation. Crystal-Right™ (CR-100) was used for the removal of ammonia from aqueous solution in batch adsorption procedure. The kinetics of adsorption followed the pseudo-second-order model. The Elovich model suggested that chemisorption rate decreased with the temperature increase. The liquid film diffusion and intra-particle diffusion models revealed that heterogeneous adsorbent surface energy had a particularly pronounced impact on the overall mass transfer rate. The Arrhenius and Eyring’s equations suggested spontaneous and endothermic nature of complex adsorption/ion exchange removal process. The isosteric heat of adsorption revealed that with the increase in surface loading lateral interactions between the adsorbed molecules occurred
Bisphosphonate related osteonecrosis of the maxilla: A case report
Introduction. Bisphosphonates are a group of medications which have an important role in the treatment of some bone diseases. Bisphosphonate-related osteonecrosis of the jaw (BRONJ) is a side effect of intravenous bisphosphonate therapy. The mechanism of action by which they may cause osteonecrosis is questionable. BRONJ is defined by the American Association of Oral and Maxillofacial Surgeons (AAOMS) and classified into four stages (0-3). Treatment of BRONJ depends on the stage of disease and includes conservative treatment (stage 0 and 1) and surgical treatment (surgical debridement in stage 2 and sequestrectomy in stage 3). Case report. We presented a patient who had breast cancer, with stage 3 of bisphosphonate-related osteonecrosis of the upper jaw after zoledronic acid therapy for diffuse metastasis of the vertebrae. Before the treatment with zoledronic acid the patient was treated by a dentist. The osteonecrosis of the upper jaw started a year and a half after the start of zoledronic acid therapy and after tooth 24 extraction. She was treated by an oral surgeon at the beginning according to the protocol of AAOMS. The patient was sent to a maxillofacial surgeon due to the disease progression, and after computed tomography (CT) examination resection of the upper jaw was done. Conclusion. BRONJ is a condition with the specific clinical presentation, and it can be very serious for the patient, therefore it is necessary to emphasize the importance of screening. The doctors in different specialties (oncologist, dentist, oral surgeon and maxillofacial surgeon) must cooperate and control the patients under treatment with bisphosphonates before the therapy starts, as well as during and after it, in order to prevent, recognize on time and treat properly this complication
Congenital cervical bronchogenic cyst: A case report
Introduction. Bronchogenic cysts are rare congenital anomalies of the
embryonic foregut. They are caused by abnormal budding of diverticulum of the
embryonic foregut between the 26th and 40th day of gestation. Bronchogenic
cysts can appear in the mediastinum and pulmonary parenchyma, or at ectopic
sites (neck, subcutaneous tissue or abdomen). So far, 70 cases of cervical
localization of bronchogenic cysts have been reported. Majority of
bronchogenic cysts have been diagnosed in the pediatric population.
Bronchogenic cysts of the cervical area are generally asymptomatic and
symptoms may occur if cysts become large or in case of infection of the cyst.
The diagnosis is made based on clinical findings, radiological examination,
but histopathologic findings are essential for establishing the final
diagnosis. Treatment of cervical bronchogenic cyst involves surgical
excision. Case Outline. Authors present a case of a 6-year-old female patient
sent by a pediatrician to a maxillofacial surgeon due to asymptomatic lump on
the left side of the neck. The patient had frequent respiratory infections
and respiratory obstructions. Magnetic resonance imaging (MRI) of the neck
was performed and a well-circumscribed cystic formation on the left side of
the neck was observed, with paratracheal location. The complete excision of
the cyst was made transcervically. Histopathological findings pointed to
bronchogenic cyst. Conclusion. Cervical bronchogenic cysts are rare
congenital malformations. Considering the location, clinical findings and the
radiological features, these cysts resemble other cervical lesions. Surgical
treatment is important because it is both therapeutic and diagnostic.
Reliable diagnosis of bronchogenic cysts is based on histopathological
examination
Original article UDC: 616.988.6:616-006.4:616-089.8 Archive of Oncology 2003;11(1):9-11. The problem of local recurrence and metastasis in soft-tissue sarcoma
BACKGROUND: The purpose of this study was to evaluate local recurrence of soft-tissue sarcomas as a prognostic factor reflecting adequate or inadequate excision. METHODS: We reviewed the cases of 53 patients who had soft-tissue sarcomas and were treated between 1991 and 2001. All patients were treated operatively, but 11 of them (20.75%), before being sent to us, were operated elsewhere with inadequate surgical margins. The oncology status, including local recurrence and metastasis was determined at the follow-up evaluation. RESULTS: All of 11 patients treated with inadequate excision had palpably or histologically determined local recurrence. The most common histological diagnosis of local recurrence was dermatofibroma protuberans (7 patients, 63.63%). In patients who were treated with planned and adequate excision there were 4 (9.52%) recurrences. Five patients (45.45%) had metastases in the group of inadequate and only one patient (1.88%) in the group of adequate surgical margins. CONCLUSION: Our study demonstrated that excellent rates of survival and low rates of local recurrence and distant metastasis of soft-tissue sarcomas could be obtained with the use of carefully planned radical resection. The quality of operation is the most important factor
A 5-year retrospective analysis of Necrotizing fasciitis: A single center experiences
Background/Aim. Necrotizing fasciitis (NF) is usually an acute infection of
superficial fascia with rapid progression in around soft tissue. If not
promptly recognized and aggressively treated NF usualy leads to sepsis and
multiorgan failure with fatal outcome, thus early diagnosis and prompt
surgical treatment are crucial for healing of these patients. The aim of this
article was to evaluate the clinical presentation of all patients with acute
NF diagnosed and treated in surgical clinics of Clinical Center of Vojvodina,
Novi Sad, Serbia. Methods. The medical records of patients treated for acute
NF localized on a different parts of the body in Clinical Center of
Vojvodina, Novi Sad, Serbia, during a 5- year period (from January 2008 to
December 2012) were retrospectively evaluated. This study enrolled patients
admitted via Emergency Center of Vojvodina with the diagnosis of acute NF
either as the primary diagnosis or with the diagnosis at discharge after
surgical treatment. Results. During a 5-year period there were 216 patients
with final diagnosis of acute NF. Most of our patients (140 - 64.81%) were
admitted with the initial diagnosis of cellulitis, abscesses, phlegmons or
sepsis. Unfortunately, the clinical symptoms of acute NF were atypical at
time of initial examination. Pain and swelling of the affected localization
were the most presented bias of symptoms (183 - 84.72%). The majority of our
patients were male (164 - 75.92%). Among the 216 patients, the most common
pre-existing single factor was drug abuse (39 - 18.05%), followed by obesity
(38 - 17.59%) and diabetes mellitus (31 - 14.35%). Trauma was most common
etiological factor (22 - 10.8%) in infected wounds, followed by abdominal (15
- 6.94%) and orthopedic (11 - 5.09%) surgical intervention. In the present
study idiopathic acute NF was diagnosed in 22 (10.18%) patients and more than
one etiological factor were diagnosed in 20 (9.25%) patients. The majority of
our patients had type I acute NF (172 - 79.62%) with Streptococcal species as
the most common microorganism (125 - 71.02%). The most common localization
was an extremity (151 - 69.90%). The minority of our patients had head and
neck localization of infection (7 - 3.24%). Surgical treatment was performed
in all the patients and most of them (183 - 84.72%) received the first
surgery within 24 h. Other patients (23 - 10.64%) received operation after
stabilization of general status or after getting the diagnosis of acute NF
(unclear diagnosis on admission). During hospitalization, the most common
complication among our patients was sepsis (156 - 72.22%). The mortality rate
was 14.35%. Conclusion. Acute NF is a rare but very difficult and sometimes
life-threatening disease of superficial fascia and around soft tissue. If
acute NF is suspected, early radical excision of all the affected tissue with
exploration and excision of superficial fascia with pathological and
microbiological assessment are most significant for treatment. Appropriate
antibiotics and intensive care setting to manage other organ failure of NF
are recommended at the same time with surgery
Eagle’s syndrome - a report of two cases
Introduction. Eagle’s syndrome is defined as elongation of the styloid
process or the stylohyoid ligament mineralization complex which consist of
styloid process, stylohyoid ligament and lesser horn of hyoid bone. It is a
rare entity, is not commonly suspected in clinical practice. It is
characterized by recurrent facial and throat pain, dysphagia, odynophagia,
parapharingeal foreign body sensation, otalgia and neck pain. Eagle’ş
syndrome can be treated conservatively (lacing local anesthetic into the
styloid process and stylomandibular ligament attachment) or surgically. Its
pathogenesis and threatment modalities are still being debated while
different theories have been presented. Case report. The two traditional
surgical approaches to styloidectomy (removal of the elongated portion of the
styloid process) were presented the intraoral approach and the extraoral
approach. We presented two cases (49 years and 34 years old males), with
bilateral and unilateral elongated styloid process. The surgical treatment
included unilateral right side stiloidectomy by intraoral approach in the
first case and right styloidectomy by extraoral approach in the second case.
In both eases post-operative course passed regularly with no complaints at
regular postoperative control. Conclusion. Surgical techniques for treatment
of Eagle’s syndrome have many advantages and disadvantages. We believe that
the length of the styloid process or the calcified ligament is a decisive
parameter for the selection of techniques and approach
Li-fraumeni syndrome: A case report
Introduction. Li-Fraumeni syndrome (LFS) is a very rare familial disease with
the predisposition to the development of malignant tumors, such as
osteosarcoma, breast cancer, brain neoplasm, leukemia, and adrenal tumors.
Inheritance is autosomal dominant and is caused by heterozygous mutations in
the p53 gene. The diagnosis is based on clinical criteria: a person under the
age of 45 years suffering from sarcoma, the closest relative younger than 45
years diagnosed with cancer and a relative of the first or second degree,
which is up to 45 years, was diagnosed with cancer and was diagnosed with
sarcoma at any age. Case report. The presented family with three members
diagnosed with malignant disease typical for LFS suggests the need to
carefully follow those diagnosed with LFS related tumor. A 24-yearold man
diagnosed and treated for osteosarcoma of the maxilla died in the first year.
His younger brother was submitted to surgery due to osteosarcoma of the
mandible three years later, and a year later in his 24 year he had no signs
of locoregional recurrence. Their mother was operated in 1996 for
glioblastoma multiform brain cancer and ductal carcinoma, and died two years
later at the age of 33. Conclusion. The presented family highlights the need
for careful examination, inspection and notification of the risks of family
members diagnosed with LFS related tumors