P416: Red cell distribution width is not a predictor of mortality in acute kidney injury

No abstract available

Reliability of Sprint Acceleration Performance and Three Repetition Maximum Back Squat Strength in Hurling Players

The purpose of this study was to estimate the inter-day reliability of 5, 10 and 20-meter sprint time and three repetition maximum back squat strength in male hurling players. Eighteen male hurling players volunteered to participate and performed 20- meter sprint trials and a three repetition maximum back squat strength test at each test session, on three separate occasions, a minimum of 48 hours apart. Participants performed three sprints over 20-meters, including split times at 5 and 10-meters. The three repetition back squat strength test was performed after the sprint test. The results displayed acceptable levels of reliability for sprint performance times (Intra class correlation coefficient single measure range: 0.76-0.89; Coefficient of variance range: 1.0 – 2.0%) and absolute and relative three repetition maximum back squat strength (Intra class correlation coefficient single measure: 0.98; CV 0.8%). Furthermore, sprint performance times and three repetition maximum back squat strength measures estimated feasible minimum a priori sample sizes from limits of agreement (5-meter:0.01 ± 0.08 s; 10-meter:-0.01 ± 0.12; 20-meter:-0.007 ± 0.15s; three repetition maximum (kg): 1.11 ± 4.19kg; three repetition maximum (kg/BW): 0.01 ± 0.06) random error therefore showing acceptable reliability. Sprint performance over 5, 10 and 20-meters and three repetition maximum back squat strength are reliable measures in male hurling players and can be used to estimate feasible minimum a priori sample sizes for sport science research

The Reliability of Countermovement Jump Performance and the Reactive Strength Index in Identifying Drop-Jump Drop Height in Hurling Players

The purpose of this study was to estimate the inter-day reliability of countermovement jump performance (CMJ) and the reactive strength index (RSI) in identifying drop-jump drop height in male hurling players. Eighteen male hurling players volunteered to participate. Subjects performed the CMJ and drop-jump test for RSI during the same sessions on three separate occasions a minimum of 48 hours apart. Subjects performed three CMJs and two drop-jumps from five different heights in an incremental manner (0.20, 0.30, 0.40, 0.50, 0.60 m). The results displayed acceptable levels of relative and absolute reliability for the following CMJ measures: height, velocity, force, power and average eccentric rate of force development measures (RFD). Absolute and relative peak concentric rate of force development from the CMJ test were found to have low levels of absolute reliability due to high CV% values. RSI and identified drop height from the drop-jump test displayed acceptable reliability (ICC single measure = 0.88 and 0.92 respectively; CV% = 6% and 10% respectively). Furthermore, limits of agreement random error displayed acceptable reliability for CMJ and drop-jump measures from estimated feasible minimum a priori sample sizes based upon limits of agreement. In conclusion, CMJ force-time measures (excluding peak concentric RFD measures), RSI and the identified drop height have acceptable absolute and relative reliability. For the sport science practitioner involved in hurling and for hurling players, this means that the CMJ test is reliable for kinetic and kinematic variables and the drop-jump test provides a means of developing a reactive strength profile and a means of individualizing drop height for drop-jump training

Neuromuscular and Bounce Drop-Jump Responses to Different Inter-Repetition Rest Intervals during A Composite Training Session in Hurling Players

The purposes of this study were to a) compare a 4-min to an 8-min rest interval between composite training (jump-sprint combination) repetitions in a single session to allow for the recovery of neuromuscular and bounce drop-jump (BDJ) performance and b) investigate if super compensation would occur after 168hrs of rest. Twelve players were randomly assigned to either a 4-min or an 8-min rest interval group. Participants first completed a BDJ test to identify individual BDJ drop heights followed by a 20m sprint test. Seventy-two hours later, a composite training session of two repetitions (three BDJs followed by a 20m sprint after a 15s rest) with either a 4-min or an 8-min rest interval was performed. A three repetition maximum (3RM) back squat strength test, a BDJ, countermovement jump (CMJ) and a sprint performance test were completed 10-mins pre- and immediately post-session, and 168 hrs post-session. CMJ force (8-min group) and BDJ (height and reactive strength index (RSI)) measures decreased significantly post-session (4-min and 8-min groups; P ≤ 0.05). Pre-session to 168 hrs post-session, relative 3RM back squat strength and 20m sprint performance increased significantly for the 4-min group only (P ≤ 0.05). In conclusion, a 4-min composite training inter-repetition rest interval leads to a significant decline in BDJ measures (RSI and jump height) which may act as fatigue markers for monitoring. However, 4-mins provides sufficient recovery during the session which, in conjunction with 168 hrs of recovery, causes super compensation in neuromuscular performance in hurling players

A poxviral homolog of the Pellino protein inhibits Toll and Toll-like receptor signalling

Toll-like receptor (TLR) signalling pathways constitute an evolutionarily conserved component of the host immune response to pathogenic infection. Here, we describe the ability of a virally encoded form of the Pellino protein to inhibit Toll- and TLR-mediated activation of downstream Rel family transcription factors. In addition to inhibiting drosomycin promoter activation by Spa¨ tzle in Drosophila melanogaster cells, viral Pellino attenuates the activation of NF-jB by TLR signalling components and by the TLR4 ligand, LPS, in human cells. We propose that viral Pellino, like mammalian Pellinos, contains a forkhead-associated domain but differs from the mammalian forms in that it lacks a complete and functional RING-like domain. We produce a homology model and present experimental data to support this model by demonstrating that, like mammalian Pellinos, viral Pellino can interact with IRAK-1 via its forkhead-associated domain, whereas unlike its mammalian counterparts, it fails to post-translationally modify IRAK-1. Furthermore, we demonstrate that viral Pellino can functionally antagonise the activity of human Pellino3S. Thus, our findings identify potential immunoevasive capabilities possessed by a poxviral homolog of the Pellino protein and add growing evidence for a likely role for Pellino proteins in Toll and TLR signalling

Selective incorporation of iododeoxyuridine into DNA of hepatic metastases versus normal human liver

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/109868/1/cptclpt1988166.pd