“We shouldn’t waste a good crisis”: the lived experience of working on the frontline through the first surge (and beyond) of COVID-19 in the UK and Ireland

Objective: Frontline workers have shown extraordinary resilience and sustained efforts since the outbreak of COVID-19. The present study used semi-structured interviews with 38 frontline workers in the UK and Ireland to explore the psychological impact of working through COVID-19. Design: The qualitative data were analysed systematically using thematic analysis. Results: Four themes were interpreted: 1)) “I’ve stopped turning the telly on. I’ve had to because the news was making me ill”: An ecosystem of influence; 2) “Dead, dead, dead”: The emotional and psychological toll: 3) “It’s shone a light on what we’re failing on as well”: Injustices, hierarchies and heroes: and 4) “I definitely think COVID happened for a reason to stop us in our tracks and to slow us down”: Unexpected positives. Conclusion: This research offers insights into how frontline workers make sense of their experiences during periods of enormous societal and occupational stress. The learnings generated have relevance for government and organisational policy makers who have opportunities to shape future conditions for frontline worker

In it together?: Exploring solidarity with frontline workers in the United Kingdom and Ireland during COVID-19

The phrase ‘in it together’ has been used liberally since the outbreak of COVID-19, but the extent that frontline workers felt ‘in it together’ is not well understood. Here, we consider the factors that built (or eroded) solidarity while working through the pandemic, and how frontline workers navigated their lives through periods of disconnection. Semi-structured interviews with 21 frontline workers, across all sectors, were conducted in the United Kingdom and Ireland. The qualitative data were analysed systematically using reflexive thematic analysis. The three themes identified in the data were: (1) Solidarity as central to frontline experiences; (2) Leadership as absent, shallow and divisive: highlighting ‘us-them’ distinctions and (3) The rise of ‘us’ and ‘we’ among colleagues. Our research offers insights into how frontline workers make sense of their experiences of solidarity and discordance during the first year of the COVID-19 pandemic, with relevance for government and organizational policy-makers shaping future conditions for frontline workers.</p

1,2,4-Triazolo-[1,5‑<i>a</i>]pyridine HIF Prolylhydroxylase Domain‑1 (PHD-1) Inhibitors With a Novel Monodentate Binding Interaction

Herein we describe the identification of 4-{[1,2,4]­triazolo­[1,5-<i>a</i>]­pyridin-5-yl}­benzonitrile-based inhibitors of the hypoxia-inducible factor prolylhydroxylase domain-1 (PHD-1) enzyme. These inhibitors were shown to possess a novel binding mode by X-ray crystallography, in which the triazolo N1 atom coordinates in a hitherto unreported monodentate interaction with the active site Fe²⁺ ion, while the benzonitrile group accepts a hydrogen-bonding interaction from the side chain residue of Asn315. Further optimization led to potent PHD-1 inhibitors with good physicochemical and pharmacokinetic properties

RURALIZATION. The opening of rural areas to renew ruralgenerations, jobs and farms: D3.3 Review Report and Fact Sheets based on previous European projects

"The RURALIZATION project aims to look at ways to overcome rural decline issues that support rural regeneration and generational renewal. The empirical focus of the project is to develop, assess and disseminate novel instruments, strategies and policies that cater for rural regeneration. This is done specificallyin relation to the future dreams of rural youth, facilitating rural newcomers and new entrants into farming and by addressing the issue of access to land. RURALIZATION will also carry out a trend analysis to uncover relevant trends for rural regions. This knowledge base will culminate in generating effective policy tools. Through this RURALIZATION aims to contribute to the development of a new rural frontier that provides exciting opportunities to new rural generations for social and economic sustainability and to realise their dreams in a rural context (...)