Epileptogenesis in wt and cD2 KO mice following intra-amygdala kainic acid injection.

<p><b>(A)</b> Neurodegeneration in CA3 of the hippocampus at 8 d after KA-induced status epilepticus. <b>(B)</b> Duration of status epilepticus, <b>(C)</b> percent of animals developing epilepsy, <b>(D)</b> latency to the first spontaneous seizure, <b>(E)</b> seizure frequency in epileptic mice and <b>(F)</b> average spontaneous seizure duration in wt and cD2 KO mice following intra-amygdala kainic acid injection. <b>(G)</b> An example of an electrographic seizure detected in a cD2 KO animal. Arrows in A indicate the area of neuronal loss. Each circle in B and D-F represents one animal, and horizontal bars indicate mean (B) or median (D-F) values; cx—cortex, KO—knock-out, SE—status epilepticus, wt—wild type.</p