Physical activity and its correlates in patients with Cystic Fibrosis: a systematic review

Regular physical activity (PA) is associated with multiple health benefits, yet little insight exists on PA levels of patients with CF (PwCF). This systematic review aimed to compare PA levels of PwCF (youth and adults) to healthy peers, and explore the influencing factors (i.e. correlates) of PA in these patients.Medline (PubMed), Web of Science and PsychArticles were systematically searched for eligible literature and 46 studies were included, describing 2351 PwCF.PwCF are~as active as their~healthy peers, although CF youth tend to be less active at higher PA intensities. In addition, both groups do not meet PA guidelines set by the World Health Organization (WHO)[Bull,F.C.et al. Br J Sports Med 2020;54:1451-1462]. PA is positively associated with quality of life, lung function, exercise capacity, bone mineral density and quadriceps force, and negatively with weekday and respiratory exacerbations (table). No associations were found with age, pancreatic insufficiency, or colonisation with bacteria.PwCF and healthy peers are equally active, but do not meet WHO guidelines. Several PA correlates that were widely investigated in the healthy population remain undetermined (e.g. sex) or unknown (e.g. behavioural factors, parental support, access to green space) in PwCF. However, these correlates could form excellent target points to improve PA. More high-quality research is needed to further unravel the PA behaviour of PwCF.FootnotesCite this article as Eur Respir J 2022; 60: Suppl. 66, 700.This article was presented at the 2022 ERS International Congress, in session {\textquotedblleft}-{\textquotedblright}.This is an ERS International Congress abstract. No full-text version is available. Further material to accompany this abstract may be available at www.ers-education.org (ERS member access only)

Physical activity and its correlates in people with cystic fibrosis: a systematic review

Cystic fibrosis (CF) is a life-shortening genetic disease, affecting multiple life domains including physical activity (PA). Although higher PA levels are associated with multiple health benefits, little insight exists on the PA level of people with CF (PwCF) compared to healthy peers. Evidence on the influencing factors (i.e. correlates) of PA in this clinical population is scarce, but essential to fully understand their PA behaviour. Therefore, the present review aims to provide an overview of the PA level of PwCF compared to healthy peers, and the correlates of PA in PwCF. A systematic search of three databases resulted in 46 included studies. Analysis of 16 studies showed that the CF population is equally active compared to healthy peers, but there is a trend towards less high-intensity PA in youths with CF. Furthermore, PA is positively associated with quality of life, lung function, (maximal) exercise capacity, bone mineral density and quadriceps force. Also, PA was lower on weekdays compared to weekend days and lower when experiencing pulmonary exacerbations. More high-quality research is required in PwCF, particularly longitudinal studies that further explore the correlates of PA, with PA investigated as a primary outcome and measured objectively