10 research outputs found
Magic/mythic stories and children's development: The case of the father Christmas story
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Shining Lights in Unexpected Corners: New angles on young children's spiritual development
- Author
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study
Evaporation
- Author
- ACM Beljaars
- B Seguin
- B Seguin
- B Seguin
- B Seguin
- BJ Choudhury
- BJ Choudhury
- BJ Choudhury
- BJ Choudhury
- BJ Choudhury
- C Ottle
- C Ottle
- CS Jha
- CW Thornthwaite
- CW Thornthwaite
- D Kaneko
- DS Kimes
- EN Kairu
- G D’Urso
- G D’Urso
- G D’Urso
- GC Wollenweber
- GJA Nieuwenhuis
- GJR Soer
- GR Diak
- GR Diak
- H Pelgrum
- HAM Thunnissen
- HJ Bolle
- HL Penman
- I Sandholt
- J Shukla
- J Susskind
- J Wang
- J Wieringa
- JC Price
- JL Heilman
- JM Norman
- JP Lagouarde
- JP Peixoto
- KE Saxton
- KJ Beven
- KS Humes
- L Zhang
- LA Bruijnzeel
- LE Hipps
- LR Stone
- M Menenti
- M Menenti
- M Menenti
- M Menenti
- M Menenti
- M Menenti
- M Segal
- MA Friedl
- MC Anderson
- ME Jensen
- MS Moran
- MS Moran
- N Sato
- O Taconet
- O Taconet
- P Reiniger
- PA Bresnahan
- PH Schuepp
- PJ Camillo
- PJ Wetzel
- PM Seevers
- R Brasa
- RA Feddes
- RCG Smith
- RD Jackson
- RD Jackson
- RD Jackson
- RG Allen
- RJ Gurney
- RJ Harding
- RR Nemani
- RR Nemani
- RR Nemani
- RT Pinker
- RT Wetherald
- SD Schubert
- SM Moran
- SM Moran
- SN Goward
- SR Vieira
- T Oki
- TJ Majumdar
- TN Carlson
- TN Carlson
- TN Carlson
- TN Carlson
- TN Carlson
- V Caselles
- VI Myers
- VP Starr
- W Eichinger
- WB Rossow
- WGM Bastiaanssen
- WGM Bastiaanssen
- WL Darnell
- WP Kustas
- WP Kustas
- WP Kustas
- WP Kustas
- WP Kustas
- WP Kustas
- XH Yang
- Y Inoue
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2000
- Field of study
Comprehensive genomic characterization of head and neck squamous cell carcinomas
- Author
- Agrawal Nishant
- Agrawal Nishant
- Ahn Julie
- Akbani Rehan
- Aksoy B. Arman
- Ally Adrian
- Auman J. Todd
- Baboud Julien
- Balasundaram Miruna
- Balu Saianand
- Baylin Stephen B.
- Beard Christina
- Benz Christopher
- Benz Stephen
- Beroukhim Rameen
- Biroi Inanc
- Bishop Justin
- Bishop Justin
- Black Aaron D.
- Bodenheimer Thomas
- Boice Lori
- Bollag Roni
- Bootwalla Moiz
- Boutros Paul C.
- Boutros Paul C.
- Bowen Jay
- Bowlby Reanne
- Bradford Carol R.
- Bristow Christopher A.
- Brooks Denise
- Brown Brandee T.
- Bruce Jeff P.
- Bruce Jeff P.
- Buda Elizabeth
- Burnett Ken
- Burnett Ken
- Burton Robert A.
- Butterfield Yaron S. N.
- Byers Lauren Averett
- Califano Joseph
- Califano Joseph
- Carey Thomas E.
- Carey Thomas E.
- Carlsen Rebecca
- Carter Scott L.
- Casasent Tod
- Chan Timothy A.
- Chang Kyle
- Chao Hsu
- Chen Chu
- Chen Zhong
- Cheng Dean
- Cheng Hui
- Chepeha Douglas B.
- Chera Bhishamjit S.
- Cherniack Andrew D.
- Chin Lynda
- Chin Lynda
- Chiosea Simion I.
- Chiosea Simion I.
- Cho Juok
- Chu Andy
- Cibulskisl Kristian
- Ciriello Giovanni
- Cohen Ezra
- Cope Leslie
- Crain Daniel
- Curley Erin
- Danilova Ludmila
- Davidsen Tanja
- Demchok John A.
- Dhalla Noreen
- Diao Lixia
- DiCara Daniel
- Diergaarde Brenda
- Diergaarde Brenda
- Doddapaneni HarshaVardhan
- Dresdner Gideon
- Drummond Jennifer A.
- Egea Sophie
- Egloff Ann Marie
- Egloff Ann Marie
- El-Naggar Adel K.
- Eley Greg
- Fan You Hong
- Ferguson Martin L.
- Ferris Robert L.
- Ferris Robert L.
- Frazer Scott
- Frederick Mitchell J.
- Freeman Samuel S.
- Frick Jessica
- Funkhouser William K.
- Gabriel Stacey B.
- Gabriel Stacey B.
- Gao Jianjiong
- Gardner Johanna
- Gardner Johanna
- Gastier-Foster Julie M.
- Gehlenborg Nils
- Getz Gad
- Getz Gad
- Gibbs Richard A.
- Golusinski Pawel
- Golusinski Wojciech
- Gomez-Fernandez Carmen
- Grandis Jennifer R.
- Gross Benjamin
- Guin Ranabir
- Gulley Margaret L.
- Guo Yan
- Guo Yan
- Hackman Trevor G.
- Haddad Andrea S.
- Haddad Robert I.
- Hadjipanayis Angela
- Hale Walker
- Hammerman Peter S.
- Hammerman Peter S.
- Han Yi
- Harper Hollie A.
- Harris Thomas
- Haseley Psalm
- Hayes D. Neil
- Hayes D. Neil
- Hayes D. Neil
- Hayward Michele C.
- Heiman David I.
- Herbert Lynn
- Herman James G.
- Hoadley Katherine A.
- Holt Robert A.
- Hoyle Alan P.
- Huang Mei
- Hui Angela B. Y.
- Hui Angela B. Y.
- Ibbs Matthew
- Irish Jonathan
- Jacobsen Anders
- Jefferys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J. M.
- Jones Tamara R.
- Jung Joonil
- Kahn An B.
- Kakkar Nipun
- Khan Zubair
- Kim Jaegil
- Kimes Patrick K.
- Komarck Christine M.
- Korski Konstanty
- Kovar Christie
- Kucherlapati Raju
- Ladanyi Marc
- Lander Eric
- Larid Peter W.
- Lau Kevin
- Lauskis Joseph Pau
- Lawrence Michael S.
- Lawrence Michael S.
- Le Yiling
- Lee Darlene
- Lee J. Jack
- Lee Semin
- Lee William
- Leraas Kristen
- Li Haiyan I.
- Lichtenberg Tara M.
- Lichtenstein Lee
- Lie Jinze
- Lin Pei
- Lippman Scott M.
- Lippman Scott M.
- Liu Fei-Fei
- Liu Fei-Fei
- Liu Wenbin
- Liu Yingchun
- Liu Yufeng
- Mackiewicz Andrzej
- Maglinte Dennis T.
- Mahadeshwar Harshad S.
- Malakh Mayya
- Mallery David
- Mallery David
- Marra Marco A.
- Marron J. S.
- Mayo Michael
- McHugh Jonathan B.
- McHugh Jonathan B.
- Meng Shaowu
- Meyerson Matthew
- Mieczkowski Piotr A.
- Mille Gordon
- Mitchell Colleen
- Moore Richard A.
- Morris Luc G.
- Morris Scott
- Morton Donna
- Mose Lisle E.
- Motter Thomas
- Moyer Jeffrey S.
- Mungall Andrew J.
- Muzny Donna
- Myers Jeff
- Myers Jeff
- Ng Patrick Kwok Shing
- Ng Sam
- Nguyen Ariane
- Noble Michael S.
- Ojesina Akinyemi I.
- Ozenberger Bradley A.
- Pantazi Angeliki
- Parfenov Michael
- Park Peter J.
- Parker Joel S.
- Pedamallu Chandra Sekhar
- Penny Robert
- Penny Robert
- Perez-Ordonez Bayardo
- Perez-Ordonez Bayardo
- Perou Charles M.
- Peterson Lisa A.
- Pham Michelle
- Pickering Curtis R.
- Pihl Todd D.
- Pot David A.
- Prince Mark E.
- Prins Jan F.
- Protopopov Alexei
- Prystowsky Michael
- Ramirez Nilsa C.
- Ramirez Ricardo
- Rathmell W. Kimryn
- Reid Jeff
- Ren Xiaojia
- Reva Boris
- Roach Jeffrey
- Robertson A. Gordon
- Romkes Marjorie
- Romkes Marjorie
- Rozek Laura S.
- Saksena Gordon
- Salazar Ashley H.
- Saleh Anthony D.
- Saller Charles
- Sander Chris
- Sandusky George
- Santoso Netty
- Sartor Maureen A.
- Sartor Maureen A.
- Schein Jacqueline E.
- Schultz Nikolaus
- Schumacher Steven E.
- Seethala Raja
- Seethala Raja
- Seidman Jonathan
- Seiwert Tanguy Y.
- Seth Sahil
- Shaw Kenna R. Mills
- Shelton Candace
- Shelton Troy
- Shelton Troy
- Shen Ronglai
- Sherman Mark
- Sheth Margi
- Shi Yan
- Shockley William W.
- Shores Carol G.
- Si Han
- Simons Janae V.
- Singh Darshan
- Sinhal Rileen
- Sipahimalan Payal
- Sofia Heidi J.
- Soloway Matthew G.
- Song Xingzhi
- Sougnez Carrie
- Sougnez Carrie
- Srinivasan Deepak
- Stojanov Petar
- Stuart Joshua
- Suchorska Wiktoria
- Sumer S. Onur
- Sun Yichao
- Szybiak Bartosz
- Tam Angela
- Tan Donghui
- Tang Jiabin
- Tarnuzzer Roy
- Tarvi Katherine
- Taylor Barry S.
- Taylor Evan G.
- Thiessen Nina
- Thorne Leigh
- Triche Timothy, Jr.
- Tward Aaron D.
- Tward Aaron D.
- Van den Berg David J.
- Van Waes Carter
- Veluvolu Umadevi
- Voet Doug
- Waggott Daryl M.
- Waggott Daryl M.
- Waldron John
- Walline Heather M.
- Walter Vonn
- Walton Jessica S.
- Wan Yunhu
- Wang Jing
- Wang Kai
- Wang Zhining
- Waring Scot
- Weinberger Paul
- Weinhold Nils
- Weinstein John
- Weisenberger Daniel J.
- Weissler Mark C.
- Wheeler David
- Wilkerson Matthew D.
- William William N., Jr.
- Wise Lisa
- Wiznerowicz Maciej
- Wiznerowicz Maciej
- Wolf Gregory T.
- Wong Tina
- Wrenn Sylvia
- Wu Junyuan
- Xi Liu
- Xu Andrew W.
- Yang Liming
- Yang Lixing
- Yarbrough Wendell G.
- Yarbrough Wendell G.
- Yau Christina
- Yena Peggy
- Yena Peggy
- Zack Travis I.
- Zanation Adam M.
- Zeng Dong
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jiexin
- Zhao Ni
- Zmuda Erik
- Zou Lihua
- Zuo Zhixiang
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 28/03/2016
- Field of study
The Cancer Genome Atlas profiled 279 head and neck squamous cell carcinomas (HNSCCs) to provide a comprehensive landscape of somatic genomic alterations. Here we show that human-papillomavirus-associated tumours are dominated by helical domain mutations of the oncogene PIK3CA, novel alterations involving loss of TRAF3, and amplification of the cell cycle gene E2F1. Smoking-related HNSCCs demonstrate near universal loss-of-function TP53 mutations and CDKN2A inactivation with frequent copy number alterations including amplification of 3q26/28 and 11q13/22. A subgroup of oral cavity tumours with favourable clinical outcomes displayed infrequent copy number alterations in conjunction with activating mutations of HRAS or PIK3CA, coupled with inactivating mutations of CASP8, NOTCH1 and TP53. Other distinct subgroups contained loss-of-function alterations of the chromatin modifier NSD1, WNT pathway genes AJUBA and FAT1, and activation of oxidative stress factor NFE2L2, mainly in laryngeal tumours. Therapeutic candidate alterations were identified in most HNSCCsclose9
History of Ecological Sciences, Part 62: Saving Habitats and Managing Wildlife in the United States and Canada before 2000
- Author
- Addy C. E.
- Aley S.
- Allen L.
- Anderson R. K.
- Barrow M. V
- Bartlett R. A.
- Bartonek J. C.
- Bean M. J.
- Bechtel S.
- Beck W. A.
- Bellrose F. C.
- Belonzi A.
- Bergoffen W
- Bertrand G. A.
- Birchard B.
- Black C.
- Black G.
- Blechman A. D.
- Boros C.
- Brands H. W.
- Brattain M.
- Brinkley D.
- Brinkley D.
- Brinkley D.
- Brodhead M. J.
- Brokow M. J.
- Brower K.
- Burgess R. L.
- Burnett A. W.
- Burnett J. A.
- Burroughs J.
- Burroughs J.
- Cain S. A.
- Cameron J.
- Cammarata P.
- Campbell C. E.
- Campbell C. E.
- Carlander K. D.
- Carroll J. M.
- Carter R. A.
- Cattell J. M.
- Chambers C. D.
- Chapman F. M.
- Cheke A.
- Clarke J. M.
- Clements F. E.
- Cohen M. P.
- Cokinos C.
- Coleman J.
- Connell E. S.
- Conway J.
- Corneli H. M.
- Craighead C.
- Croker R. A.
- Curran T. J.
- Curran T. J.
- Curtis J.
- Cutright P. R.
- Cuvier G.
- Cuvier G.
- Cuvier G.
- Day A.
- Dehler G. J.
- Dehler G. J.
- Dexter R. W.
- Dillon R. H.
- Dillon R. H.
- Dingell J. D.
- Duncan D.
- Dunlap T. R.
- Egan T.
- Egerton F. N.
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- Egerton F. N.
- Egerton F. N.
- Elton C. S.
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- Emlen J. T.
- Errington P. L.
- Errington P. L.
- Errington P. L.
- Fausold M. L.
- Flader S. L.
- Frankenberg D.
- Freedman B.
- Fuller E.
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- Gable J. A.
- Gabrielson I. N.
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- Gottschalk J. S.
- Greenberg J.
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- Greenway J. C.
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- Hamerstrom F.
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- Huth H.
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- Jackson D.
- Jacques Cattell Press
- Jahn L. R.
- James G. M.
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- Jones H. R.
- Kadlec J. A.
- Keller B.
- Kimes W. F.
- Kiviat E.
- Klyza C. M.
- Kolbert E.
- Kuhne D.
- Lannoo M. J.
- Lavender D.
- Laycock G.
- Lendt D. L.
- Leopold A. S.
- Leopold R. A.
- Leopold R. A.
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- Leopold R. A.
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- Leshuk D.
- Lincoln F. C.
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- Lowenthal D.
- Lunde D.
- Mac Phee R. D. E.
- Marsh G. P.
- Martin P. S.
- Martin P. S.
- Matthiessen P.
- Mazel D.
- Mc Nicholl M. K.
- Mc Shea W. J.
- Mc Williams W. H.
- McAtee W. L.
- McClung R. M.
- Meine C.
- Meine C.
- Meine C.
- Meine C.
- Melham T.
- Miller H. W.
- Mitman G. A.
- Morgan L. H.
- Mowat F.
- Muir J.
- Murie A.
- Murie A.
- Murie M. E.
- Murie M. E.
- Murie O.
- Murie O. J.
- Murphy R.
- Muscatine D.
- Myers R.
- Ostfeld R. S.
- Owen A. L. R.
- Pak S. J.
- Palmer T. S.
- Pegram T. R.
- Penick J.
- Penick J.
- Perry M. C.
- Pinchot G.
- Pinchot G.
- Price J.
- Reeves H. M.
- Reeves H. M.
- Reeves H. M.
- Reeves H. M.
- Reeves H. M.
- Reeves H. M.
- Reeves H. M.
- Reiger J. F.
- Reiger J. F.
- Reiger J. F.
- Reiger J. F.
- Reiger J. F.
- Renehan E. J.
- Rhodes R.
- Riegert P. W.
- Riley L.
- Ripley S. D.
- Rodgers A. D.
- Roe F. G.
- Roosevelt R. B.
- Roosevelt R. B.
- Roosevelt R. B.
- Roosevelt T.
- Rosene W.
- Samson J. G.
- Schoenfeld C. A.
- Schorger A. W.
- Schueler D. G.
- Scott T. G.
- Seaborn C.
- Sellars R. W.
- Seton E. T.
- Seton E. T.
- Seton E. T.
- Seton E. T.
- Shankland R.
- Shor E. N.
- Shor E. N.
- Sivils M. W.
- Skillen J. R.
- Smith J. C.
- Snyder N.
- Stalter R.
- Steen H. K.
- Stein B. R.
- Stejneger L.
- Sterling K. B.
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- Sterling K. B.
- Sterling K. B.
- Sterling K. B.
- Sterling K. B.
- Sterling K. B.
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- Stewart D.
- Stoddard H. L.
- Stoddard H. L.
- Stresemann E.
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- Strong D. H.
- Thomas G.
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- Tilden F.
- Tilden F.
- Trefethen J. B.
- Trombulak S. C.
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- Wetmore A.
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- Wolverton R.
- Worster D.
- Yard R. S.
- Zuzworsky R.
- Publication venue
- 'Wiley'
- Publication date
- Field of study
Quorum Sensing Signal Production and Microbial Interactions in a Polymicrobial Disease of Corals and the Coral Surface Mucopolysaccharide Layer
- Author
- A Alagely
- A Antonius
- A Bodor
- A Camilli
- A Jayaraman
- AL May
- AL Schaefer
- Amanda L. May
- AR Horswill
- AW Bruckner
- AW Decho
- AW Decho
- AW Miller
- B Vargas-Angel
- BA Van Mooy
- BE Brown
- Beth L. Zimmer
- BL Bassler
- BL Bassler
- BL Bassler
- BL Bassler
- BL Bassler
- C Buch
- C Cha
- C Fuqua
- C García-Aljaro
- C Wild
- Carson W. Prevatte
- Chinmayee D. Bhedi
- D Casamatta
- D Kessner
- D McDougald
- D Stanić
- DA Higgins
- DI Sharif
- DW Wood
- E Kramarsky-Winter
- E Melamud
- E Voelkert
- EA Yates
- Fabiano Thompson
- G Muyzer
- HC Lichstein
- HM Bandara
- HW Ducklow
- I Joint
- J Frias-Lopez
- J Nissimov
- JD Voss
- JE Gonzalez
- JL Myers
- JM Henke
- JM Henke
- JT Byers
- K Golberg
- K Riedel
- K Rützler
- K Tait
- K Tait
- KB Ritchie
- KB Xavier
- KB Xavier
- KG Kuta
- KG Kuta
- KH McClean
- KL Rypien
- KP Sutherland
- KS Koh
- L Arotsker
- L Gram
- Laurie L. Richardson
- LL Richardson
- LL Richardson
- LL Richardson
- LL Richardson
- LL Richardson
- M Chilton
- M Gantar
- M Gantar
- M Shnit-Orland
- ME Mouchka
- MF Semmelhack
- MG Surette
- MJ Gauthier
- MS Glas
- MW Taylor
- NA Burgess
- NE Kimes
- O Barneah
- P Meikle
- P Williams
- PJ Edmunds
- R Bachofen
- R Guppy
- R Sekar
- R Sekar
- R Van Houdt
- RG Carlton
- RJ Case
- RJ Jones
- RP Cooney
- RP Ryan
- S Beck von Bodman
- SC DeKeersmaecker
- SC DeKeersmaecker
- SF Altschul
- Shawn R. Campagna
- SJ McGowan
- SK Farrand
- SR Campagna
- ST Miller
- Stephen P. Dearth
- TS Charlton
- WC Fuqua
- X Chen
- XG Han
- Y Geffen
- Y Sato
- Y Sato
- YL Huang
- YL Huang
- Zoe Pratte
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- Field of study
Comprehensive molecular profiling of lung adenocarcinoma
- Author
- Akbani Rehan
- Aksoy B. Arman
- Albert Monique
- Amos Christopher I.
- Asiedu Michael K.
- Auman J. Todd
- Baboud Julien
- Balasundaram Miruna
- Balu Saianand
- Bartlett John M. S.
- Bauer Thomas
- Baylin Stephen B.
- Baylin Stephen B.
- Beer David G.
- Behera Madhusmita
- Benz Christopher C.
- Berger Alice H.
- Beroukhim Rameen
- Bodenheimer Tom
- Boice Lori
- Bonomi Philip
- Bootwalla Moiz S.
- Borgia Jeffrey A.
- Bowman Rayleen V.
- Boyd Jeff
- Brock Malcolm V.
- Brooks Angela N.
- Brooks Angela N.
- Broom Bradley M.
- Brown Jennifer
- Bryant Ayesha
- Buda Elizabeth
- Burks Eric
- Butterfield Yaron S. N.
- Byers Lauren Averett
- Byers Lauren Averett
- Cabanski Christopher
- Campbell Joshua D.
- Campbell Joshua D.
- Carlsen Rebecca
- Carter Scott L.
- Cerfolio Robert
- Chen Peng-Chieh
- Cheney Richard
- Cheney Richard
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chin Lynda
- Chin Lynda
- Chmielecki Juliann
- Chmielecki Juliann
- Cho Juok
- Chu Andy
- Chu Andy
- Chuah Eric
- Cibulskis Kristian
- Ciriello Giovanni
- Clarke Belinda
- Clarke Belinda
- Collisson Eric A.
- Cope Leslie
- Cope Leslie
- Creighton Chad J.
- Creighton Chad J.
- Curley Erin
- Czerwinski Christine
- Dacic Sanja
- Dacic Sanja
- Dang Huy Quoc Thinh
- Danilova Ludmila
- Danilova Ludmila
- Davidsen Tanja
- Demchok John A.
- Dhalla Noreen
- Dhir Rajiv
- Diao Lixia
- DiCara Daniel
- Dienemann Hendrik
- Ding Li
- Ding Li
- Dolzhanskiy Oleg
- Dresdner Gideon
- Duhig Edwina
- Duhig Edwina
- Eckman John
- Egea Sophie
- Farver Carol
- Farver Carol
- Fedosenko Konstantin V.
- Flieder Douglas
- Fong Kwun M.
- Fronick Catrina C.
- Fulton Lucinda L.
- Fulton Robert
- Funkhouser William K.
- Funkhouser William K.
- Gabriel Stacey B.
- Gabriel Stacey B.
- Gabrielson Edward
- Gal Anthony
- Gao Jianjiong
- Gardner Johanna
- Garraway Levi
- Gaudioso Carmelo
- Gehlenborg Nils
- Getz
- Getz Gad
- Getz Gad
- Getz Gad
- Gomez-Fernandez Carmen
- Goparaju Chandra
- Govindan Ramaswamy
- Govindan Ramaswamy
- Gross Benjamin
- Guin Ranabir
- Hadjipanayis Angela
- Hadjipanayis Angela
- Hajek Richard
- Hammerman Peter S.
- Haussler David
- Hayes D. Neil
- Hayes D. Neil
- Hayes D. Neil
- Heiman David
- Helman Elena
- Herbert Lynn
- Herman James G.
- Hernandez Bryan
- Hernandez Bryan
- Heymach John V.
- Heymach John V.
- Hirst Carrie
- Hoadley Katherine A.
- Hoadley Katherine A.
- Hodis Eran
- Holt Robert A.
- Holway Antonia
- Hoyle Alan P.
- Huang Mei
- Huelsenbeck-Dill Lori
- Hunter Lindy
- Iacocca Mary
- Illei Peter
- Illei Peter
- Imielinski Marcin
- Jefferys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J. M.
- Juhl Hartmut
- Jurisica Igor
- Kahn Ari B.
- Kandoth Cyriac
- Khan Khurram Z.
- Kim Jaegil
- Kimes Patrick K.
- Kodeeswaran Sugy
- Kohl Bernard
- Kosari Farhad
- Kucherlapati Raju
- Kucherlapati Raju
- Kwiatkowski David
- Ladanyi Marc
- Ladanyi Marc
- Lai Philip H.
- Laird Peter W.
- Laird Peter W.
- Lander Eric S.
- Lau Kevin
- Lawrence Michael S.
- Lawrence Michael S.
- Lee Beverly
- Lee Darlene
- Lee Semin
- Lee William
- Lee William
- Letovanec Igor
- Li Haiyan I.
- Lichtenstein Lee
- Lin Pei
- Liptay Michael J.
- Liu Jinze
- Liu Wenbin
- Lu Yiling
- Ma Singer
- Ma Singer
- Maglinte Dennis T.
- Mahadeshwar Harshad S.
- Maher Christopher A.
- Mallard William
- Mallery David
- Mardis Elaine
- Marra Marco A.
- Marron J. S.
- Mayo Michael
- McDonald Sandra
- McLellan Michael D.
- Meister Michael
- Meng Shaowu
- Mesirov Jill
- Mesirov Jill
- Meyers Bryan
- Meyerson Matthew
- Meyerson Matthew
- Mieczkowski Piotr A.
- Miller Christopher A.
- Mills Gordon B.
- Moiseenko Fedor
- Moore Richard A.
- Morris Scott
- Morrison Carl
- Muley Thomas R.
- Mungall Andrew J.
- Myers Jerome B.
- Nazaire Marc-Danie
- Nemirovich-Danchenko Elena
- Noble Michael S.
- Onofrio Robert C.
- Owusu-Sarpong Yvonne
- Ozenberger Bradley A.
- Pantazi Angeliki
- Parfenov Michael
- Parfitt Jeremy
- Park Peter J.
- Parker Joel S.
- Parker Joel S.
- Pass Harvey
- Patrick Kwok Shing Ng
- Paulauskis Joseph
- Pedamallu Chandra Sekhar
- Peifer Martin
- Pennell Nathan A.
- Penny Robert
- Perou Charles M.
- Perou Charles M.
- Peters Solange
- Petrelli Nicholas
- Pool Mark
- Pot David A.
- Potapova Olga
- Prins Jan F.
- Protopopov Alexei
- Rabeno Brenda
- Radenbaugh Amie
- Radenbaugh Amie
- Ramalingam Suresh S.
- Rathmell W. Kimryn
- Raymond Daniel P.
- Rekhtman Natasha
- Rekhtman Natasha
- Ren Xiaojia
- Reva Boris
- Richards William G.
- Rieger-Christ Kimberly
- Roach Jeffrey
- Robertson A. Gordon
- Robertson Gordon
- Robinson Jim
- Rogers Kristen
- Rosenberg Mara
- Rosenberg Mara
- Rosenberg Mara
- Rotin Daniil
- Rusch Valerie W.
- Saksena Gordon
- Saksena Gordon
- Salazar Ashley Hill
- Saller Charles
- Sam Ng
- Sander Chris
- Sandusky George
- Santoso Netty
- Schein Jacqueline E.
- Schnabel Philipp A.
- Schneider Frank
- Schultz Nikolaus
- Schultz Nikolaus
- Schumacher Steven E.
- Sekhon Harmanjatinder
- Seshan Venkatraman E.
- Seth Sahil
- Shaw Kenna R. Mills
- Shelton Troy
- Shen Ronglai
- Shen Ronglai
- Sheth Margi
- Shi Yan
- Shin James
- Sica Gabriel
- Sica Gabriel
- Siegfried Jill M.
- Simons Janae V.
- Singh Darshan
- Sinha Rileen
- Sinha Rileen
- Sipahimalani Payal
- Snyder Eric E.
- Sofia Heidi J.
- Soloway Matthew G.
- Song Xingzhi
- Sougnez Carrie
- Sougnez Carrie
- Sougnez Carrie
- Spellman Paul T.
- Srinivasan Deepak
- Stewart Chip
- Stuart Joshua M.
- Stuart Joshua M.
- Suh James
- Suh James
- Sullivan Travis
- Sumer S. Onur
- Tam Angela
- Tan Donghui
- Tang Jiabin
- Tarnuzzer Roy
- Tarvin Katherine
- Taylor Barry S.
- Thiessen Nina
- Thorne Leigh B.
- Thorvaldsdottir Helga
- Travis William D.
- Travis William D.
- Travis William D.
- Triche Timothy, Jr.
- Trusty Dante
- Tsao Ming-Sound
- Tsao Ming-Sound
- Van Den Berg David J.
- Varhol Richard
- Veluvolu Umadevi
- Voet Douglas
- Voronina Olga
- Wang Jing
- Wang Zhining
- Waring Scot
- Watson Mark A.
- Weaver JoEllen
- Weinhold Nils
- Weinstein John N.
- Weinstein John N.
- Weisenberger Daniel J.
- Weisenberger Daniel J.
- Wendl Michael C.
- Wheeler David
- Wigle Dennis A.
- Wigle Dennis A.
- Wilkerson Matthew D.
- Wilkerson Matthew D.
- Williamson Christina
- Wilson Richard K.
- Windsor Morgan
- Wu Junyuan
- Wye Natasja
- Xu Andrew Wei
- Yang Ian A.
- Yang Liming
- Yang Lixing
- Yau Christina
- Ye Kai
- Yousem Samuel A.
- Zack Travis
- Zakowski Maureen
- Zaytseva Irina
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jianhua
- Zhu Jingchun
- Zippile Paul
- Zou Lihua
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/06/2013
- Field of study
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen(mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesisclose24
Comprehensive molecular profiling of lung adenocarcinoma
- Author
- Akbani Rehan
- Aksoy B. Arman
- Albert Monique
- Amos Christopher I.
- Asiedu Michael K.
- Auman J. Todd
- Baboud Julien
- Balasundaram Miruna
- Balu Saianand
- Bartlett John M. S.
- Bauer Thomas
- Baylin Stephen B.
- Baylin Stephen B.
- Beer David G.
- Behera Madhusmita
- Benz Christopher C.
- Berger Alice H.
- Beroukhim Rameen
- Bodenheimer Tom
- Boice Lori
- Bonomi Philip
- Bootwalla Moiz S.
- Borgia Jeffrey A.
- Bowman Rayleen V.
- Boyd Jeff
- Brock Malcolm V.
- Brooks Angela N.
- Brooks Angela N.
- Broom Bradley M.
- Brown Jennifer
- Bryant Ayesha
- Buda Elizabeth
- Burks Eric
- Butterfield Yaron S. N.
- Byers Lauren Averett
- Byers Lauren Averett
- Cabanski Christopher
- Campbell Joshua D.
- Campbell Joshua D.
- Carlsen Rebecca
- Carter Scott L.
- Cerfolio Robert
- Chen Peng-Chieh
- Cheney Richard
- Cheney Richard
- Cherniack Andrew D.
- Cherniack Andrew D.
- Chin Lynda
- Chin Lynda
- Chmielecki Juliann
- Chmielecki Juliann
- Cho Juok
- Chu Andy
- Chu Andy
- Chuah Eric
- Cibulskis Kristian
- Ciriello Giovanni
- Clarke Belinda
- Clarke Belinda
- Collisson Eric A.
- Cope Leslie
- Cope Leslie
- Creighton Chad J.
- Creighton Chad J.
- Curley Erin
- Czerwinski Christine
- Dacic Sanja
- Dacic Sanja
- Danilova Ludmila
- Danilova Ludmila
- Davidsen Tanja
- Demchok John A.
- Dhalla Noreen
- Dhir Rajiv
- Diao Lixia
- DiCara Daniel
- Dienemann Hendrik
- Ding Li
- Ding Li
- Dolzhanskiy Oleg
- Dresdner Gideon
- Duhig Edwina
- Duhig Edwina
- Eckman John
- Egea Sophie
- Farver Carol
- Farver Carol
- Fedosenko Konstantin V.
- Flieder Douglas
- Fong Kwun M.
- Fronick Catrina C.
- Fulton Lucinda L.
- Fulton Robert
- Funkhouser William K.
- Funkhouser William K.
- Gabriel Stacey B.
- Gabriel Stacey B.
- Gabrielson Edward
- Gal Anthony
- Gao Jianjiong
- Gardner Johanna
- Garraway Levi
- Gaudioso Carmelo
- Gehlenborg Nils
- Getz Gad
- Getz Gad
- Getz Gad
- Gomez-Fernandez Carmen
- Goparaju Chandra
- Govindan Ramaswamy
- Govindan Ramaswamy
- Gross Benjamin
- Guin Ranabir
- Hadjipanayis Angela
- Hadjipanayis Angela
- Hajek Richard
- Hammerman Peter S.
- Haussler David
- Hayes D. Neil
- Hayes D. Neil
- Hayes D. Neil
- Heiman David
- Helman Elena
- Herbert Lynn
- Herman James G.
- Hernandez Bryan
- Hernandez Bryan
- Heymach John V.
- Heymach John V.
- Hirst Carrie
- Hoadley Katherine A.
- Hoadley Katherine A.
- Hodis Eran
- Holt Robert A.
- Holway Antonia
- Hoyle Alan P.
- Huang Mei
- Huelsenbeck-Dill Lori
- Hunter Lindy
- Iacocca Mary
- Illei Peter
- Illei Peter
- Imielinski Marcin
- Jefferys Stuart R.
- Jensen Mark A.
- Jones Corbin D.
- Jones Steven J. M.
- Juhl Hartmut
- Jurisica Igor
- Kahn Ari B.
- Kandoth Cyriac
- Khan Khurram Z.
- Kim Jaegil
- Kimes Patrick K.
- Kodeeswaran Sugy
- Kohl Bernard
- Kosari Farhad
- Kucherlapati Raju
- Kucherlapati Raju
- Kwiatkowski David
- Ladanyi Marc
- Ladanyi Marc
- Lai Philip H.
- Laird Peter W.
- Laird Peter W.
- Lander Eric S.
- Lau Kevin
- Lawrence Michael S.
- Lawrence Michael S.
- Lee Beverly
- Lee Darlene
- Lee Semin
- Lee William
- Lee William
- Letovanec Igor
- Li Haiyan I.
- Lichtenstein Lee
- Lin Pei
- Liptay Michael J.
- Liu Jinze
- Liu Wenbin
- Lu Yiling
- Ma Singer
- Ma Singer
- Maglinte Dennis T.
- Mahadeshwar Harshad S.
- Maher Christopher A.
- Mallard William
- Mallery David
- Mardis Elaine
- Marra Marco A.
- Marron J. S.
- Mayo Michael
- McDonald Sandra
- McLellan Michael D.
- Meister Michael
- Meng Shaowu
- Mesirov Jill
- Mesirov Jill
- Meyers Bryan
- Meyerson Matthew
- Meyerson Matthew
- Mieczkowski Piotr A.
- Miller Christopher A.
- Mills Gordon B.
- Moiseenko Fedor
- Moore Richard A.
- Morris Scott
- Morrison Carl
- Muley Thomas R.
- Mungall Andrew J.
- Myers Jerome B.
- Nazaire Marc-Danie
- Nemirovich-Danchenko Elena
- Noble Michael S.
- Onofrio Robert C.
- Owusu-Sarpong Yvonne
- Ozenberger Bradley A.
- Pantazi Angeliki
- Parfenov Michael
- Parfitt Jeremy
- Park Peter J.
- Parker Joel S.
- Parker Joel S.
- Pass Harvey
- Paulauskis Joseph
- Pedamallu Chandra Sekhar
- Peifer Martin
- Pennell Nathan A.
- Penny Robert
- Perou Charles M.
- Perou Charles M.
- Peters Solange
- Petrelli Nicholas
- Pool Mark
- Pot David A.
- Potapova Olga
- Prins Jan F.
- Protopopov Alexei
- Rabeno Brenda
- Radenbaugh Amie
- Radenbaugh Amie
- Ramalingam Suresh S.
- Rathmell W. Kimryn
- Raymond Daniel P.
- Rekhtman Natasha
- Rekhtman Natasha
- Ren Xiaojia
- Reva Boris
- Richards William G.
- Rieger-Christ Kimberly
- Roach Jeffrey
- Robertson A. Gordon
- Robertson Gordon
- Robinson Jim
- Rogers Kristen
- Rosenberg Mara
- Rosenberg Mara
- Rosenberg Mara
- Rotin Daniil
- Rusch Valerie W.
- Saksena Gordon
- Saksena Gordon
- Salazar Ashley Hill
- Saller Charles
- Sander Chris
- Sandusky George
- Santoso Netty
- Schein Jacqueline E.
- Schnabel Philipp A.
- Schneider Frank
- Schultz Nikolaus
- Schultz Nikolaus
- Schumacher Steven E.
- Sekhon Harmanjatinder
- Seshan Venkatraman E.
- Seth Sahil
- Shaw Kenna R. Mills
- Shelton Troy
- Shen Ronglai
- Shen Ronglai
- Sheth Margi
- Shi Yan
- Shin James
- Sica Gabriel
- Sica Gabriel
- Siegfried Jill M.
- Simons Janae V.
- Singh Darshan
- Sinha Rileen
- Sinha Rileen
- Sipahimalani Payal
- Snyder Eric E.
- Sofia Heidi J.
- Soloway Matthew G.
- Song Xingzhi
- Sougnez Carrie
- Sougnez Carrie
- Sougnez Carrie
- Spellman Paul T.
- Srinivasan Deepak
- Stewart Chip
- Stuart Joshua M.
- Stuart Joshua M.
- Suh James
- Suh James
- Sullivan Travis
- Sumer S. Onur
- Tam Angela
- Tan Donghui
- Tang Jiabin
- Tarnuzzer Roy
- Tarvin Katherine
- Taylor Barry S.
- Thiessen Nina
- Thorne Leigh B.
- Thorvaldsdottir Helga
- Travis William D.
- Travis William D.
- Travis William D.
- Triche Timothy, Jr.
- Trusty Dante
- Tsao Ming-Sound
- Tsao Ming-Sound
- Van Den Berg David J.
- Varhol Richard
- Veluvolu Umadevi
- Voet Douglas
- Voronina Olga
- Wang Jing
- Wang Zhining
- Waring Scot
- Watson Mark A.
- Weaver JoEllen
- Weinhold Nils
- Weinstein John N.
- Weinstein John N.
- Weisenberger Daniel J.
- Weisenberger Daniel J.
- Wendl Michael C.
- Wheeler David
- Wigle Dennis A.
- Wigle Dennis A.
- Wilkerson Matthew D.
- Wilkerson Matthew D.
- Williamson Christina
- Wilson Richard K.
- Windsor Morgan
- Wu Junyuan
- Wye Natasja
- Xu Andrew Wei
- Yang Ian A.
- Yang Liming
- Yang Lixing
- Yau Christina
- Ye Kai
- Yousem Samuel A.
- Zack Travis
- Zakowski Maureen
- Zaytseva Irina
- Zenklusen Jean Claude
- Zhang Hailei
- Zhang Jianhua
- Zhang Jianhua
- Zhu Jingchun
- Zippile Paul
- Zou Lihua
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2014
- Field of study
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen(mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis
Comprehensive molecular profiling of lung adenocarcinoma: the cancer genome atlas research network
- Author
- Collisson Eric A.
- Campbell Joshua D.
- Brooks Angela N.
- Berger Alice H.
- Lee William
- Chmielecki Juliann
- Beer David G.
- Cope Leslie
- Creighton Chad J.
- Danilova Ludmila
- Ding Li
- Getz Gad
- Hammerman Peter S.
- Hayes D. Neil
- Hernandez Bryan
- Herman James G.
- Heymach John V.
- Jurisica Igor
- Kucherlapati Raju
- Kwiatkowski David
- Ladanyi Marc
- Robertson Gordon
- Schultz Nikolaus
- Shen Ronglai
- Sinha Rileen
- Sougnez Carrie
- Tsao Ming-Sound
- Travis William D.
- Weinstein John N.
- Wigle Dennis A.
- Wilkerson Matthew D.
- Chu Andy
- Cherniack Andrew D.
- Hadjipanayis Angela
- Rosenberg Mara
- Weisenberger Daniel J.
- Laird Peter W.
- Radenbaugh Amie
- Ma Singer
- Stuart Joshua M.
- Byers Lauren Averett
- Baylin Stephen B.
- Govindan Ramaswamy
- Rosenberg Mara
- Gabriel Stacey B.
- Cibulskis Kristian
- Sougnez Carrie
- Kim Jaegil
- Stewart Chip
- Lichtenstein Lee
- Lander Eric S.
- Lawrence Michael S.
- Getz
- Kandoth Cyriac
- Fulton Robert
- Fulton Lucinda L.
- McLellan Michael D.
- Wilson Richard K.
- Ye Kai
- Fronick Catrina C.
- Maher Christopher A.
- Miller Christopher A.
- Wendl Michael C.
- Cabanski Christopher
- Ding Li
- Mardis Elaine
- Govindan Ramaswamy
- Creighton Chad J.
- Wheeler David
- Balasundaram Miruna
- Butterfield Yaron S. N.
- Carlsen Rebecca
- Chu Andy
- Chuah Eric
- Dhalla Noreen
- Guin Ranabir
- Hirst Carrie
- Lee Darlene
- Li Haiyan I.
- Meyerson Matthew
- Mayo Michael
- Moore Richard A.
- Mungall Andrew J.
- Schein Jacqueline E.
- Sipahimalani Payal
- Tam Angela
- Varhol Richard
- Robertson A. Gordon
- Wye Natasja
- Thiessen Nina
- Holt Robert A.
- Jones Steven J. M.
- Marra Marco A.
- Campbell Joshua D.
- Brooks Angela N.
- Chmielecki Juliann
- Imielinski Marcin
- Onofrio Robert C.
- Hodis Eran
- Zack Travis
- Sougnez Carrie
- Helman Elena
- Pedamallu Chandra Sekhar
- Mesirov Jill
- Cherniack Andrew D.
- Saksena Gordon
- Schumacher Steven E.
- Carter Scott L.
- Hernandez Bryan
- Garraway Levi
- Beroukhim Rameen
- Gabriel Stacey B.
- Getz Gad
- Hadjipanayis Angela
- Lee Semin
- Mahadeshwar Harshad S.
- Pantazi Angeliki
- Protopopov Alexei
- Ren Xiaojia
- Seth Sahil
- Song Xingzhi
- Meyerson Matthew
- Tang Jiabin
- Yang Lixing
- Zhang Jianhua
- Chen Peng-Chieh
- Parfenov Michael
- Xu Andrew Wei
- Santoso Netty
- Chin Lynda
- Park Peter J.
- Kucherlapati Raju
- Hoadley Katherine A.
- Auman J. Todd
- Meng Shaowu
- Shi Yan
- Buda Elizabeth
- Waring Scot
- Veluvolu Umadevi
- Tan Donghui
- Mieczkowski Piotr A.
- Jones Corbin D.
- Simons Janae V.
- Soloway Matthew G.
- Bodenheimer Tom
- Jefferys Stuart R.
- Roach Jeffrey
- Hoyle Alan P.
- Wu Junyuan
- Balu Saianand
- Singh Darshan
- Prins Jan F.
- Marron J. S.
- Parker Joel S.
- Hayes D. Neil
- Perou Charles M.
- Liu Jinze
- Cope Leslie
- Danilova Ludmila
- Weisenberger Daniel J.
- Maglinte Dennis T.
- Lai Philip H.
- Bootwalla Moiz S.
- Van Den Berg David J.
- Triche Timothy, Jr.
- Baylin Stephen B.
- Laird Peter W.
- Rosenberg Mara
- Chin Lynda
- Zhang Jianhua
- Cho Juok
- DiCara Daniel
- Heiman David
- Lin Pei
- Mallard William
- Voet Douglas
- Zhang Hailei
- Zou Lihua
- Noble Michael S.
- Lawrence Michael S.
- Saksena Gordon
- Gehlenborg Nils
- Thorvaldsdottir Helga
- Mesirov Jill
- Nazaire Marc-Danie
- Robinson Jim
- Getz Gad
- Lee William
- Aksoy B. Arman
- Ciriello Giovanni
- Taylor Barry S.
- Dresdner Gideon
- Gao Jianjiong
- Gross Benjamin
- Seshan Venkatraman E.
- Ladanyi Marc
- Reva Boris
- Sinha Rileen
- Sumer S. Onur
- Weinhold Nils
- Schultz Nikolaus
- Shen Ronglai
- Sander Chris
- Sam Ng
- Ma Singer
- Zhu Jingchun
- Radenbaugh Amie
- Stuart Joshua M.
- Benz Christopher C.
- Yau Christina
- Haussler David
- Spellman Paul T.
- Wilkerson Matthew D.
- Parker Joel S.
- Hoadley Katherine A.
- Kimes Patrick K.
- Hayes D. Neil
- Perou Charles M.
- Broom Bradley M.
- Wang Jing
- Lu Yiling
- Patrick Kwok Shing Ng
- Diao Lixia
- Byers Lauren Averett
- Liu Wenbin
- Heymach John V.
- Amos Christopher I.
- Weinstein John N.
- Akbani Rehan
- Mills Gordon B.
- Curley Erin
- Paulauskis Joseph
- Lau Kevin
- Morris Scott
- Shelton Troy
- Mallery David
- Gardner Johanna
- Penny Robert
- Saller Charles
- Tarvin Katherine
- Richards William G.
- Cerfolio Robert
- Bryant Ayesha
- Raymond Daniel P.
- Pennell Nathan A.
- Farver Carol
- Czerwinski Christine
- Huelsenbeck-Dill Lori
- Iacocca Mary
- Petrelli Nicholas
- Rabeno Brenda
- Brown Jennifer
- Bauer Thomas
- Dolzhanskiy Oleg
- Potapova Olga
- Rotin Daniil
- Voronina Olga
- Nemirovich-Danchenko Elena
- Fedosenko Konstantin V.
- Gal Anthony
- Behera Madhusmita
- Ramalingam Suresh S.
- Sica Gabriel
- Flieder Douglas
- Boyd Jeff
- Weaver JoEllen
- Kohl Bernard
- Dang Huy Quoc Thinh
- Sandusky George
- Juhl Hartmut
- Duhig Edwina
- Illei Peter
- Gabrielson Edward
- Shin James
- Lee Beverly
- Rogers Kristen
- Trusty Dante
- Brock Malcolm V.
- Williamson Christina
- Burks Eric
- Rieger-Christ Kimberly
- Holway Antonia
- Sullivan Travis
- Wigle Dennis A.
- Asiedu Michael K.
- Kosari Farhad
- Travis William D.
- Rekhtman Natasha
- Zakowski Maureen
- Rusch Valerie W.
- Zippile Paul
- Suh James
- Pass Harvey
- Goparaju Chandra
- Owusu-Sarpong Yvonne
- Bartlett John M. S.
- Kodeeswaran Sugy
- Parfitt Jeremy
- Sekhon Harmanjatinder
- Albert Monique
- Eckman John
- Myers Jerome B.
- Cheney Richard
- Morrison Carl
- Gaudioso Carmelo
- Borgia Jeffrey A.
- Bonomi Philip
- Pool Mark
- Liptay Michael J.
- Moiseenko Fedor
- Zaytseva Irina
- Dienemann Hendrik
- Meister Michael
- Schnabel Philipp A.
- Muley Thomas R.
- Peifer Martin
- Gomez-Fernandez Carmen
- Herbert Lynn
- Egea Sophie
- Huang Mei
- Thorne Leigh B.
- Boice Lori
- Salazar Ashley Hill
- Funkhouser William K.
- Rathmell W. Kimryn
- Dhir Rajiv
- Yousem Samuel A.
- Dacic Sanja
- Schneider Frank
- Siegfried Jill M.
- Hajek Richard
- Watson Mark A.
- McDonald Sandra
- Meyers Bryan
- Clarke Belinda
- Yang Ian A.
- Fong Kwun M.
- Hunter Lindy
- Windsor Morgan
- Bowman Rayleen V.
- Peters Solange
- Letovanec Igor
- Khan Khurram Z.
- Jensen Mark A.
- Snyder Eric E.
- Srinivasan Deepak
- Kahn Ari B.
- Baboud Julien
- Pot David A.
- Shaw Kenna R. Mills
- Sheth Margi
- Davidsen Tanja
- Demchok John A.
- Yang Liming
- Wang Zhining
- Tarnuzzer Roy
- Zenklusen Jean Claude
- Ozenberger Bradley A.
- Sofia Heidi J.
- Travis William D.
- Cheney Richard
- Clarke Belinda
- Dacic Sanja
- Duhig Edwina
- Funkhouser William K.
- Illei Peter
- Farver Carol
- Rekhtman Natasha
- Sica Gabriel
- Suh James
- Tsao Ming-Sound
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/10/2008
- Field of study
Adenocarcinoma of the lung is the leading cause of cancer death worldwide. Here we report molecular profiling of 230 resected lung adenocarcinomas using messenger RNA, microRNA and DNA sequencing integrated with copy number, methylation and proteomic analyses. High rates of somatic mutation were seen (mean 8.9 mutations per megabase). Eighteen genes were statistically significantly mutated, including RIT1 activating mutations and newly described loss-of-function MGA mutations which are mutually exclusive with focal MYC amplification. EGFR mutations were more frequent in female patients, whereas mutations in RBM10 were more common in males. Aberrations in NF1, MET, ERBB2 and RIT1 occurred in 13% of cases and were enriched in samples otherwise lacking an activated oncogene, suggesting a driver role for these events in certain tumours. DNA and mRNA sequence from the same tumour highlighted splicing alterations driven by somatic genomic changes, including exon 14 skipping in MET mRNA in 4% of cases. MAPK and PI(3)K pathway activity, when measured at the protein level, was explained by known mutations in only a fraction of cases, suggesting additional, unexplained mechanisms of pathway activation. These data establish a foundation for classification and further investigations of lung adenocarcinoma molecular pathogenesis
Teacher Competence
- Author
- Adams E. W.
- Adams E. W.
- Adams W. C. T.
- Adams W. C. T.
- Albert H. R.
- Allen H. P.
- Allen Hollis P.
- Almack J. C.
- Almack J. C.
- Almy H. V.
- An Editorial
- an Editorial
- an Editorial
- an editorial
- an editorial
- Andersen W. N.
- Anderson C. S.
- Anderson D. A.
- Anderson Vivienne
- Anderson M. E. and others
- Antell Henry
- Apgar Genevieve
- Archer C. P.
- Archer Clifford P.
- Archer Clifford P.
- Aretz C. W.
- Armstrong F. E.
- Arny C. B.
- Ashley V. S.
- Atkinson E. W.
- Austin S. Carolyn
- Baer J. A.
- Bagley W. C.
- Bain Winifred E.
- Baird James
- Baird J. and others
- Baker B. K.
- Baker F. E.
- Baker G. M.
- Ball L. B.
- Balliet T. M.
- Ballou F. W.
- Ballou F. W.
- Bamberger Florence E.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S.
- Barr A. S. and others
- Barr A. S. and others
- Barthelmess Harriet M.
- Bathurst J. E.
- Baxter B.
- Beaty O. W.
- Beck A. D.
- Beckner H. B.
- Beecher Dwight E.
- Behrens H. D.
- Bell A. L.
- Bell V. M.
- Bemson Oliver H.
- Bent Rudyard K.
- Besdine Matthew
- Betts G. H.
- Betts Gilbert L.
- Betts Gilbert L.
- Betts Gilbert L.
- Betts Gilbert L.
- Betts Gilbert L.
- Bird V. A.
- Birkelo C. P.
- Blair J. M.
- Blessing C. W.
- Blewett Ben
- Blewett Ben
- Blisk T. Erwin
- Blum Lawrence P.
- Blyler Dorothea
- Boardman Charles W.
- Boden A. O.
- Bone H. A.
- Bonser F. G.
- Bossing Nelson L.
- Bousfield Weston A.
- Bowman E. C.
- Bowman Earl C.
- Boyce A. C.
- Boynton F. D.
- Bradley J. H.
- Bradshaw F. F.
- Bradshaw F. F.
- Brandenburg G. C.
- Brandenburg G. C.
- Brandwein P. F.
- Breckenridge Elizabeth
- Breed F. S.
- Breslich E. R.
- Brookover Wilbur B.
- Brookover Wilbur B.
- Broom M. E.
- Broom M. E.
- Broom M. E.
- Brown C. D.
- Brown Clara M.
- Brown E. J.
- Brown M. C.
- Brownell S. A.
- Brownell S. M.
- Brubacher A. R.
- Brueckner L. J.
- Brueckner L. J.
- Brueckner Leo J.
- Bryan R. C.
- Bryan Roy C.
- Bryan Roy C.
- Bryan Roy C.
- Buckingham B. R.
- Buellsesfield Henry
- Burke Arvid J.
- Burnham E. S.
- Burns C. A.
- Bursch Charles W.
- Bush A. S.
- Buswell Guy T.
- Butler F. A.
- Butler F. A.
- Butsch Russell L. C.
- Cahoon G. P.
- Cahoon G. P.
- Cahoon G. P.
- Callahan Sterling G.
- Cammack I. I.
- Camp C.
- Carrigan R. A.
- Carrigan Rose A.
- Carrigan Rose A.
- Carrington Evelyn M.
- Carroll J. S.
- Cattell Raymond B.
- Champlin Carroll D.
- Charters W. W.
- Cheyette I.
- Chrisman L. H.
- Clapp F. L.
- Clark M. G.
- Clark R. C.
- Clarke W. F.
- Clem Orlie M.
- Clement J. H.
- Clevenger Arthur W.
- Clinton R. J.
- Cocking W. D.
- Coffman Lotus D.
- Collicott J. G.
- Collings Ellsworth
- Collins E. A.
- Committee of Southern Educators. A.
- Connor W. L.
- Cook J. W.
- Cook Walter W.
- Cook Walter W.
- Cook William A.
- Cooley E. G.
- Cooper D. H.
- Copper F. L.
- Corey Stephen M.
- Corey Stephen M.
- Corson David B.
- Cosgrove Elizabeth
- Courtis S. A.
- Courtis S. A.
- Courtis S. A.
- Courtis S. A.
- Courtis Stuart A.
- Coxe W. W.
- Crabtree J. W.
- Crissy William J. E.
- Cruttendin Edwin W.
- Cullen J. A.
- Cunningham M.
- Curtis F. D.
- Dagley William C.
- Daltharp C. J.
- Davenport F. I.
- David V. Tiedeman
- Davidson William M.
- Davies J. Earl
- Davis Burton E.
- Davis C. O.
- Davis C. O.
- Davis Frederick B.
- Davis H.
- Davis R. A.
- Davis Robert A. and others
- Day L. C.
- Dean C. D.
- Dearborn F.
- Deffenbaugh W. S.
- Denbigh John H.
- Denning R. O.
- Deutsch Monroe E.
- Diamond Thomas
- Dix Lester
- Dodge A. F.
- Doerr C.
- Doughty W. F.
- Douglass H. R.
- Dragoo A. W.
- Driggs Joseph B.
- Durflinger Glenn W.
- Durflinger Glenn W.
- Duvall R. A.
- Dyer Franklin B.
- Eberhart R.
- Eddins A. W.
- Edmonson J. B.
- Eldred L.
- Eldredge A. C.
- Eliassen R. H.
- Elliott Edward C.
- Elliott Edward C.
- Elliott Edward C.
- Elliott Edward C.
- Engleman J. O.
- Erickson A. E.
- Ericson E. E.
- Ericson E. E.
- Ericson Emanuel E.
- Evans R. O.
- Evenden E. S.
- Evenden E. S.
- Evenden E. S.
- Evenden Edward S.
- Ewing P. L.
- Ewing P. L. and others
- Farr T. J.
- Fichandler A.
- Fichandler Alexander
- Fish L. F.
- Fish Louis J.
- Fitzpatrick F. B.
- Flagg R. C.
- Flam August
- Flanagan John C.
- Flinn Vee
- Flory Charles D.
- Folk Philip H.
- Fordyce Charles
- Foster F. M.
- Fowlkes John Guy
- Fox F. G.
- Frank J. O.
- Frazier B. W.
- Frazier C. M.
- Frederick P. M.
- Frederick Robert W.
- Freilich Helen
- Fritz Ralph A.
- Frongen C. G. F.
- Fullerton Charles H.
- Fulton Reed
- Ganders Harry S.
- Garvey E. F.
- Getman A. K.
- Giachino J. W.
- Giese W. J.
- Gilchrist R. S.
- Gilmore M. E.
- Gilmore M. E.
- Gilson H. V.
- Gorman A. E. and others
- Goslin H.
- Goslin W. E.
- Gosling Thomas W.
- Gotham R. E.
- Gould G.
- Gray C. A.
- Gray H. M.
- Gray W. S.
- Green C. C.
- Green R. A.
- Green R. A.
- Griffin J. D. M.
- Griffin William E.
- Guthrie E. R.
- Hacker L. W.
- Haggard William W.
- Haggerty M. E.
- Hall-Quest A. L.
- Hall-Quest A. L.
- Hallman M. S.
- Hamilton H. Clifford
- Hammond E. K.
- Hammond Gertrude B.
- Hamstra R. H.
- Hansen Basil C.
- Hanson E. M.
- Hanson Earl H.
- Hardesty Cecil F.
- Harms H.
- Harrington W.
- Hawthorn A.
- Hayes M.
- Heffelfinger J. B.
- Hellfritzsch A. G.
- Henderson Ruth
- Herd Edmund J. M.
- Herda F. J.
- Herrick Mary
- Herring John P.
- Herriott M. E.
- Herron Franklyn A.
- Hess A. H.
- Hess Adoh
- Hickman Joseph
- Hill G. E.
- Hill L. B.
- Hill L. B.
- Hobson Claude V.
- Hodgdon D. R.
- Hoel L.
- Holty F. L.
- Hopkins L. Thomas
- Hopkins Wilfred C.
- Hoppock Robert
- Howe M. E.
- Huggett A. J.
- Hughes C. C.
- Hughes H. F.
- Hughes W. Harding
- Hullfish H. G.
- Hulse Melvin L.
- Hult Esther
- Humke H. L.
- Hunt Thelma
- Ireland Oliver C.
- Jarman A. M.
- Jayne C. D.
- Jeffers G. B.
- Jenkins Albian U.
- Jersild Arthur T.
- Jones E. S.
- Jones J. W.
- Jones Olive M.
- Jones Ronald D.
- Judd Charles A.
- Kandel I. L.
- Keighin M. A.
- Keith R.
- Kelly M. R.
- Kelner B. G.
- Kemp L. C. D.
- Kennard R. B.
- Kent D. C.
- Kilpatrick William H. and others
- Kimball Florence
- Kimes F. M.
- Kinder J. S.
- King L. A.
- Kirby Byron C.
- Kittrell Charles A.
- Klapper P.
- Knapp T. J.
- Knight F. B.
- Knight F. B.
- Knight F. B. and Others
- Knoble J. W.
- Knox W. T.
- Knudsen Charles W.
- Kohibrenner B. J.
- Kolstad Arthur
- Koopman G. R.
- Koos L. V.
- Kramer J. H.
- Kramer S. E.
- Kriner H. L.
- Kriner H. L.
- Kriner H. L.
- Kuenzli Irvin R.
- Kyte G. C.
- LaDuke C. V.
- Lain Nell E.
- Lamson Edna F.
- Lancaster J. H.
- Lancelot W. H.
- Lancelot William H.
- Landsittel F. C.
- Landsittel F. C.
- Lane Bess B.
- Lane R. H.
- Larson Arthur H.
- LaRue Daniel W.
- Laycock S. R.
- Laycock S. R.
- Laycock Sam R.
- Learned W. S.
- Learned W. S.
- Leevy J. R.
- Lehman Harvey C.
- Leonard V. E.
- Lessenger W. E. and others
- Linder I. H.
- Lins Leo J.
- Littler R.
- Littler Sherman
- Loomis O. E.
- Loparte W. R.
- Ludeman W. W.
- Ludeman Walter W.
- Lull H. G.
- Lynch J. M.
- Lynch James M.
- MacDonald Marion E.
- MacDougall E. F.
- MacDowell Theodore L.
- Madsen I. N.
- Major C. L.
- Major C. L.
- Malan C. T.
- Manahan J. L.
- Manley H.
- Markt A. R.
- Masters Harry V.
- Mathews Lee H.
- Matt D. C.
- Matteson B. H.
- Maxwell G. E.
- Mayse S. G.
- McBroom M. M.
- McConnell R. E.
- McCormick C. F.
- McCuskey D.
- McCuskey Dorothy
- McGaughy J. R.
- McLeary R. D.
- McNally E. J.
- Mead A. R.
- Mead A. R.
- Mead Cyrus D.
- Meeks L. H.
- Megroth E. J.
- Merriman E. D.
- Messenger H. R.
- Messler W. A.
- Miel A.
- Miles L. E.
- Miller B. W.
- Miller R.
- Miller V.
- Miller W. A.
- Mills J. S.
- Mills L. S.
- Misner P. J.
- Mitchell C.
- Moehlman Arthur B.
- Mones Leon
- Monroe W. S.
- Moore J. G.
- Morgan A. L.
- Morgan DeWitt S.
- Morgan J. E.
- Morrill T. C.
- Morris E. H.
- Morrison Katherine
- Morton Robert L.
- Moses Cleda V.
- Moss F. A.
- Moss F. A. and others
- Myers G. C.
- Neel M. O.
- Nelson A. C.
- Nemec L. G.
- Nix E.
- Norvell G. W.
- Nutting Edwin P.
- Olson W. C.
- Organovic Nicholas J.
- O’Brien Howard V.
- O’Neil M. V.
- O’Rourke L. J.
- Palmer G. H.
- Palmer George H.
- Parrott A. L.
- Parsons G. B.
- Paustian H. J.
- Paustian H. J.
- Peabody Robert W.
- Pederson H. A.
- Peik W. E.
- Peters D. W.
- Peterson O. K.
- Peterson H. A. and others
- Phillips E. D.
- Phillips V.
- Pierce D. H.
- Pitkin Fred E.
- Posey C. W.
- Pottle H. L.
- Puffer R. A.
- Pulliam R.
- Pusey Edwin D.
- Pygman C. H.
- Pyle W. H.
- Pyle W. H.
- Rafter A. L.
- Raths L. E.
- Raths Louis
- Reavis William C.
- Reed Carrol R.
- Reitell C.
- Reitz William, and others
- Remmers H. H.
- Remmers H. H.
- Remmers H. H.
- Remmers H. H.
- Reynolds B. E.
- Reynolds O. E. and others
- Rhoad C. E.
- Rich Frank M.
- Richardson H.
- Riddle A.
- Rinsland Martha A. O.
- Risley J. H.
- Ritchie M.
- Roberts J. E.
- Roberts R. W.
- Robinson T. E.
- Roehl L. M.
- Rogers Virgil M.
- Rolfe J. F.
- Rostker L. E.
- Rostker L. E.
- Rostker Leon E.
- Rowland A. L.
- Ruediger W. C.
- Ruediger W. C.
- Rulon Phillip J.
- Rummell F. U.
- Ryan C. T.
- Ryans D. G.
- Ryans David G.
- Ryans David G.
- Ryans David G.
- Saer H.
- Samuelson E. E.
- Sandison M.
- Schaffle Albert E. E.
- Schellhammer Fred M.
- Schlueter W. H.
- Schmidtman M.
- Schutte T. H.
- Schweppe E.
- Schweppe Emma
- Scudder J. W.
- Sells Sane B.
- Selvidge R. W.
- Senger Harry L.
- Senska N. M.
- Seyfert W. C.
- Seymour O. J.
- Shane H. G.
- Shaner J. D.
- Shannon J. R.
- Shannon J. R.
- Shannon J. R.
- Shannon John R.
- Shannon John R.
- Shiels A.
- Showalter B. R.
- Shuster Lillian
- Simeon J. Domas
- Simon D. L.
- Simonson R.
- Simpson R. H.
- Sires R. V.
- Skimin Eleanor
- Smith A.
- Smith A. A.
- Smith Allan A.
- Smith E. L.
- Smith H. L.
- Smith H. P.
- Smith J. R.
- Snavely Guy E.
- Snedden David
- Snyder Roy P.
- Soderquist H. O.
- Soldan F. L.
- Sollars Velna
- Somers Grover T.
- Sorenson Herbert
- Spaulding Francis T.
- Steiner M. A.
- Steiner R. W.
- Stewart May L.
- Stiles L. J.
- Stoddard A. J.
- Storm A. Van
- Strebel R. F.
- Stroh M. Margaret
- Strong John A.
- Stuit D. B.
- Stuit D. B.
- Stuit Dewey B.
- Stutsman I. E.
- Sutherland S. S.
- Sutton T. C.
- Symonds Percival M.
- Taylor H.
- Taylor H. R.
- Taylor J. S.
- Taylor Joseph S.
- Thayer V. T.
- Thomas F. W.
- Thoming T.
- Thompson A. C.
- Thompson Anna M.
- Thompson C. O.
- Thompson Frank E.
- Thompson Frank E.
- Thornton James W.
- Thwing C. F.
- Tidyman W. F.
- Tiegs E. W.
- Torgerson T. L.
- Torgerson T. L.
- Traxler Arthur E.
- Trow W. C.
- Trow W. C.
- Troyer M. E.
- Troyer Maurice E.
- Troyer Maurice E.
- Troyer Maurice E.
- Trusler V. T.
- Tuell H. E.
- Tuggle M. A.
- Twiss George R.
- U. S. Office of Indian Affairs
- Ullman Roy R.
- Unruh A.
- Upshall C. C.
- Upshall C. C.
- Vaeth J. G.
- Van Denburg Joseph K.
- Van Denburg Joseph K.
- Van Oot B. H.
- Van Sickle J. H.
- Vasche J. B.
- Von Eschen C. R.
- Von Haden Herbert I.
- Waddell C. W.
- Wagenhorst L. H.
- Wagner C. A.
- Wagner C. A.
- Wagner Charles A.
- Waidelich A. G.
- Waits L. A.
- Walker F. T.
- Walker M.
- Ward William D.
- Warfield W. C.
- Weber C. A.
- Weber S. E.
- Weidemann C. C.
- Weitman E.
- West H. C.
- Westie A. W.
- Wetzel William A.
- Whipple G. M.
- White H. V.
- Whitelaw John B.
- Whitner C. L.
- Whitney E. R.
- Willard F. E.
- Williams J. H.
- Wilson J. Douglas
- Witham E. C.
- Witty Paul A.
- Witty Paul A.
- Wood B.
- Wood Ben D.
- Woody Clifford
- Word Aubrey H.
- Worthy H. D.
- Wright F. L.
- Wrightstone J. W.
- Wrightstone J. Wayne
- Wrinkle W. L.
- Wykoff G. S.
- Wykoff George S.
- Xavier Sister Mary
- Yaukey J. V.
- Yocum A. D.
- Young Frank
- Young W. E.
- Zant J. H.
- Publication venue
- 'Informa UK Limited'
- Publication date
- Field of study