1 research outputs found
A Synthesis of “Dual Warhead” β‑Aryl Ethenesulfonyl Fluorides and One-Pot Reaction to β‑Sultams
Herein, we report
an operationally simple, ligand- and additive-free
oxidative boron-Heck coupling that is compatible with the ethenesulfonyl
fluoride functional group. The protocol proceeds at room temperature
with chemoselectivity and <i>E</i>-isomer selectivity and
offers facile access to a wide range of β-aryl/heteroaryl ethenesulfonyl
fluorides from commercial boronic acids. Furthermore, we demonstrate
a “one-pot click” reaction to directly transform the
products to aryl-substituted β-sultams