Frequency of DNA copy number alterations of all 93 samples for the whole genome.

<p>Gains are represented in blue, losses in red.</p

Kaplan Meier survival curves showing the number of CNAs and the overall survival.

<p>(A) For all stages, **P = 0,004; (B) for stage IV, *P = 0,015; (C) for stage I, *P = 0,019 and (D) for stage II, *P = 0,019. In the survival curve three groups can be distinguished; the group with less than twelve alterations (blue), the group with twelve untill twenty alterations (green) and the group with more than twenty alterations (red).</p

Kaplan Meier survival curves represented a worse prognosis for patients with loss of chromosome 4.

<p>Loss of chromosome 4 is linked with a shorter RFS, ***P<0,001 (A) and a smaller 2-year OS, **P = 0,002 (B). Patients without an alteration of chromosome 4 are presented in green, those with loss of chromosome 4 in blue.</p

Gain of 16p13.3 is linked with a worse prognosis.

<p>(A) The relation of alteration of the 16p13.3 locus and the number of CNA in the corresponding patient for all tumour stages, R = -0,430 and ***P<0,001. (B) Kaplan Meier survival curve showing a worse prognosis for patients with a gain of the 16p13.3 locus over all tumour stages, **P = 0,010. Gains are represented in green, losses in blue and patients without an alteration are represented in red.</p