Investigation of jetting piping system in the spudcan of wind turbine installation jack-up vessel

The offshore wind turbine in shallow water is installed by a self-elevated mobile unit which is usually\ud referred to as jack-up barge or jack-up vessel. The jack-up vessel consists of a buoyant platform together with\ud independent legs that can position the vessel above the water reducing external loadings for safe operation condition.\ud The retrieval process of jack-up legs could be very difficult due to the high extraction resistance caused by soft soil. In\ud soft clay, since the high suction force can be developed around the spudcan attached at the end of jack-up legs, a jetting\ud system is required to break the suction to pull out the legs. It is important to design the jetting system with optimized\ud piping arrangement to allow the easy operation. There are various factors to be considered in the design of jetting piping\ud system since the level of embedment and the type of soil and pipe size and locations, etc. can affect the performance of\ud the system. In this paper, the design of 500m^3/hr jetting system is introduced with PIPENET program analysis. Also\ud the various consideration factors in the analysis are discussed

REMOVED: Optimization of VMD Process as Draw Solution Recovery Unit in FO Process

This article has been removed: please see Elsevier Policy on Article Withdrawal (http://www.elsevier.com/locate/withdrawalpolicy).This article has been removed at the request of the Executive Publisher.This article has been removed because it was published without the permission of the author(s)

Pressure-induced phase transitions and superconductivity in magnesium carbides

Crystal structure prediction and in silico physical property observations guide experimental synthesis in high-pressure research. Here, we used magnesium carbides as a representative example of computational high-pressure studies. We predicted various compositions of Mg-C compounds up to 150 GPa and successfully reproduced previous experimental results. Interestingly, our proposed MgC2 at high pressure >7 GPa consists of extended carbon bonds, one-dimensional graphene layers, and Mg atomic layers, which provides a good platform to study superconductivity of metal intercalated graphene nano-ribbons. We found that this new phase of MgC2 could be recovered to ambient pressure and exhibited a strong electron-phonon coupling (EPC) strength of 0.6 whose corresponding superconductivity transition temperature reached 15 K. The EPC originated from the cooperation of the out-of-plane and the in-plane phonon modes. The geometry confinement and the hybridization between the Mg s and C p(z) orbitals significantly affect the coupling of phonon modes and electrons. These results show the importance of the high-pressure route to the synthesis of novel functional materials, which can promote the search for new phases of carbon-based superconductors.11Ysciescopu

Polyethylene wear particles play a role in development of osteoarthritis via detrimental effects on cartilage, meniscus, and synovium

SummaryObjectiveWhile ultra-high molecular weight polyethylene (UHMWPE) wear particles are known to cause periprosthetic osteolysis, its interaction with other intra-articular tissues in the case of partial joint arthroplasties is not well understood. We hypothesized that UHMWPE particles per se would interact with intra-articular tissue, which by acting as inflammatory reservoirs, would subsequently induce osteoarthritic (OA) changes. Our goal was to assess the inflammatory response, phagocytic activity, as well as apoptosis of intra-articular cells in the presence of UHMWPE particles in vitro, and the in vivo response of those tissues after intra-articular injection of particles in a murine model.DesignThree cell types were used for the in vitro study; chondrocytes, meniscal fibrochondrocytes, and synoviocytes. Each cell type was cultured with two different concentrations of UHMWPE particles. Pro-inflammatory cytokine production, phagocytosis, and apoptosis were analyzed. In vivo experiments were done by injecting two concentrations of UHMWPE particles into normal and murine OA model knee joints.ResultsIn vitro experiments showed that UHMWPE particles increase pro-inflammatory cytokine and mediator (IL-1β, IL-6, TNF-α, Nitric Oxide, and Prostaglandin E2) production, phagocytosis of particles, and apoptosis in all cell types. In vivo experiment showed degeneration of cartilage and meniscus, as well as synovitis after particle injection.ConclusionsUHMWPE wear particles per se exert detrimental effects in cartilage, synovium, and meniscus of the knee joint resulting in pro-inflammatory cytokine release, phagocytosis of particles and apoptosis. Particles induced and exacerbated OA changes in a murine model

Children As Researchers: Exploring Issues And Barriers In English Primary Schools

This thesis identifies and explores the issues and barriers that appear to influence children's and adults' experiences of children's engagement in self-directed empirical research in five English primary schools associated with the Children's Research Centre at The Open University. As far as is known, this is the first in-depth study of children as independent researchers in the context of English primary schools. A flexible, multimethod research design was adopted. Predominantly qualitative data was generated through focus groups held with, and questionnaires distributed to, the young researchers and their peers and through individual unstructured interviews with adults. The qualitative data generated through these methods was analysed in the style of Grounded Theory (Glaser and Strauss, 1967; Strauss and Corbin, 1998). Quantitative data was subject to exploratory data analysis. This complemented and informed the qualitative analyses. The central categories which emerged from the data and, in particular, the identification of important issues by the children, have together informed the staged construction of a new model. This model illustrates the factors and processes that had an impact on both the children's experiences of research training and the research process and outcomes. The model demonstrates that these are inextricably interrelated. It is hoped that consideration of the issues and barriers identified will provide a basis for the further implementation and evaluation of young researcher initiatives in schools. The findings of the study have been drawn on to make recommendations for policy, practice and future research, particularly in those areas which are identified as significant by, and to, the children involved. It is also hoped that this study will address a gap in our knowledge and understanding of children as researchers and inform critical debate concerning children's voice and participation, adult-child power relationships and children's rights in English primary schools and more widely

Visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging

We report a three dimensional (3D) quantitative visualization of a mammalian mitochondrion by coherent x-ray diffractive imaging (CXDI) using synchrotron radiation. The internal structures of a mitochondrion from a mouse embryonic fibroblast cell line (NIH3T3) were visualized by tomographic imaging at approximately 60 nm resolution without the need for sectioning or staining. The overall structure consisted of a high electron density region, composed of the outer and inner membranes and the cristae cluster, which enclosed the lower density mitochondrial matrix. The average mass density of the mitochondrion was about 1.36 g/cm3. Sectioned images of the cristae reveal that they have neither a baffle nor septa shape but were instead irregular. In addition, a high resolution, about 14 nm, 2D projection image was captured of a similar mitochondrion with the aid of strongly scattering Au reference objects. Obtaining 3D images at this improved resolution will allow CXDI to be an effective and nondestructive method for investigating the innate structure of mitochondria and other important life supporting organelles. ? 2017 The Author(s).11Ysciescopu

Golgi Outpost Synthesis Impaired by Toxic Polyglutamine Proteins Contributes to Dendritic Pathology in Neurons

Dendrite aberration is a common feature of neurodegenerative diseases caused by protein toxicity, but the underlying mechanisms remain largely elusive. Here, we show that nuclear polyglutamine (polyQ) toxicity resulted in defective terminal dendrite elongation accompanied by a loss of Golgi outposts (GOPs) and a decreased supply of plasma membrane (PM) in Drosophila class IV dendritic arborization (da) (C4 da) neurons. mRNA sequencing revealed that genes downregulated by polyQ proteins included many secretory pathway-related genes, including COPII genes regulating GOP synthesis. Transcription factor enrichment analysis identified CREB3L1/CrebA, which regulates COPII gene expression. CrebA overexpression in C4 da neurons restores the dysregulation of COPII genes, GOP synthesis, and PM supply. Chromatin immunoprecipitation (ChIP)-PCR revealed that CrebA expression is regulated by CREB-binding protein (CBP), which is sequestered by polyQ proteins. Furthermore, co-overexpression of CrebA and Rac1 synergistically restores the polyQ-induced dendrite pathology. Collectively, our results suggest that GOPs impaired by polyQ proteins contribute to dendrite pathology through the CBP-CrebA-COPII pathway. ? 2017 The Author(s)113Ysciescopu

Extremal black holes in the Ho\v{r}ava-Lifshitz gravity

We study the near-horizon geometry of extremal black holes in the $z=3$ Ho\v{r}ava-Lifshitz gravity with a flow parameter $\lambda$. For $\lambda>1/2$, near-horizon geometry of extremal black holes are AdS$_2 \times S^2$ with different radii, depending on the (modified) Ho\v{r}ava-Lifshitz gravity. For $1/3\le \lambda \le 1/2$, the radius $v_2$ of $S^2$ is negative, which means that the near-horizon geometry is ill-defined and the corresponding Bekenstein-Hawking entropy is zero. We show explicitly that the entropy function approach does not work for obtaining the Bekenstein-Hawking entropy of extremal black holes.Comment: 18 pages, v2:some points on Lifshitz black holes claified, v3: version to appear in EJP

Analysis and prevention of dent defects formed during strip casting of twin-induced plasticity steels

Rapid-solidification experiments were conducted for understanding dent defects formed during strip casting of twin-induced plasticity (TWIP) steels. The rapid-solidification experiments reproduced the dent defects formed on these steels, which were generally located at valleys of the shot-blasted roughness on the substrate. The rapid-solidification experiment results reveal that the number of dips, the Mn content of the steel, and the surface roughness of the substrate affect the depth and size of dents formed on the solidified-shell surfaces, while the composition of the atmosphere gases and the carbon content of the steel are not factors. The formation of dents was attributed to the entrapment of gases inside the roughness valleys of the substrate surface and their volume expansion due to the temperature of the steel melt and the latent heat. The dents could be prevented when the thermal expansion of gases was suppressed by making longitudinal grooves on the substrate surface, which allowed the entrapped gases to escape. Sound solidified shells were obtained by optimizing the width and depth of the longitudinal grooves and by controlling the shot-blasting conditions.ope