2,719 research outputs found

    Symmetry Breaking Phase Transitions in ABJM Theory with a Finite U(1) Chemical Potential

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    We consider the U(1) charged sector of ABJM theory at finite temperature, which corresponds to the Reissner-Nordstrom AdS black hole in the dual type IIA supergravity description. Including back-reaction to the bulk geometry, we show that phase transitions occur to a broken phase where SU(4) R-symmetry of the field theory is broken spontaneously by the condensation of dimension one or two operators. We show both numerically and analytically that the relevant critical exponents for the dimension one operator agree precisely with those of mean field theory in the strongly coupled regime of the large N planar limit.Comment: 22 pages, 6 figures, typos corrected, references added, improved figures, minor changes, accepted for publication in Phys. Rev.

    Detective quantum efficiency of photon-counting x-ray detectors.

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    PURPOSE: Single-photon-counting (SPC) x-ray imaging has the potential to improve image quality and enable novel energy-dependent imaging methods. Similar to conventional detectors, optimizing image SPC quality will require systems that produce the highest possible detective quantum efficiency (DQE). This paper builds on the cascaded-systems analysis (CSA) framework to develop a comprehensive description of the DQE of SPC detectors that implement adaptive binning. METHODS: The DQE of SPC systems can be described using the CSA approach by propagating the probability density function (PDF) of the number of image-forming quanta through simple quantum processes. New relationships are developed to describe PDF transfer through serial and parallel cascades to accommodate scatter reabsorption. Results are applied to hypothetical silicon and selenium-based flat-panel SPC detectors including the effects of reabsorption of characteristic/scatter photons from photoelectric and Compton interactions, stochastic conversion of x-ray energy to secondary quanta, depth-dependent charge collection, and electronic noise. Results are compared with a Monte Carlo study. RESULTS: Depth-dependent collection efficiency can result in substantial broadening of photopeaks that in turn may result in reduced DQE at lower x-ray energies (20-45 keV). Double-counting interaction events caused by reabsorption of characteristic/scatter photons may result in falsely inflated image signal-to-noise ratio and potential overestimation of the DQE. CONCLUSIONS: The CSA approach is extended to describe signal and noise propagation through photoelectric and Compton interactions in SPC detectors, including the effects of escape and reabsorption of emission/scatter photons. High-performance SPC systems can be achieved but only for certain combinations of secondary conversion gain, depth-dependent collection efficiency, electronic noise, and reabsorption characteristics

    The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies

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    <p>Abstract</p> <p>Background</p> <p><it>Zymomonas mobilis </it>ZM4 is a Gram-negative bacterium that can efficiently produce ethanol from various carbon substrates, including glucose, fructose, and sucrose, <it>via </it>the Entner-Doudoroff pathway. However, systems metabolic engineering is required to further enhance its metabolic performance for industrial application. As an important step towards this goal, the genome-scale metabolic model of <it>Z. mobilis </it>is required to systematically analyze <it>in silico </it>the metabolic characteristics of this bacterium under a wide range of genotypic and environmental conditions.</p> <p>Results</p> <p>The genome-scale metabolic model of <it>Z. mobilis </it>ZM4, ZmoMBEL601, was reconstructed based on its annotated genes, literature, physiological and biochemical databases. The metabolic model comprises 579 metabolites and 601 metabolic reactions (571 biochemical conversion and 30 transport reactions), built upon extensive search of existing knowledge. Physiological features of <it>Z. mobilis </it>were then examined using constraints-based flux analysis in detail as follows. First, the physiological changes of <it>Z. mobilis </it>as it shifts from anaerobic to aerobic environments (i.e. aerobic shift) were investigated. Then the intensities of flux-sum, which is the cluster of either all ingoing or outgoing fluxes through a metabolite, and the maximum <it>in silico </it>yields of ethanol for <it>Z. mobilis </it>and <it>Escherichia coli </it>were compared and analyzed. Furthermore, the substrate utilization range of <it>Z. mobilis </it>was expanded to include pentose sugar metabolism by introducing metabolic pathways to allow <it>Z. mobilis </it>to utilize pentose sugars. Finally, double gene knock-out simulations were performed to design a strategy for efficiently producing succinic acid as another example of application of the genome-scale metabolic model of <it>Z. mobilis</it>.</p> <p>Conclusion</p> <p>The genome-scale metabolic model reconstructed in this study was able to successfully represent the metabolic characteristics of <it>Z. mobilis </it>under various conditions as validated by experiments and literature information. This reconstructed metabolic model will allow better understanding of <it>Z. mobilis </it>metabolism and consequently designing metabolic engineering strategies for various biotechnological applications.</p

    Antiosteoporosis Activity of New Oriental Medicine Preparation (Kyungokgo Mixed with Water Extract of Hovenia dulcis

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    Protective effect of new oriental medicine (Kyungokgo mixed with water extract of Hovenia dulcis, KOGHD) was assessed on the bone loss induced mice by ovariectomy. In the in vivo experiments, antiosteoporosis effect of KOGHD was investigated using ovariectomized osteoporosis mice model. After 6 weeks of treatment, the mice were euthanized, and the effect of Kyungokgo (KOG) and KOGHD on body weight, spleen weigh, thymus weight, uterine weight, serum biochemical indicators, bone weight and length, immune cell population, bone morphometric parameters, and histological stains was observed. Our results showed that KOGHD prevented the deterioration of trabecular microarchitecture caused by ovariectomy, which were accompanied by the lower levels of bone turnover markers and immune cell population as evidenced by the inhibition of RANKL-mediated osteoclast differentiation without cytotoxic effect on bone marrow derived macrophages (BMMs). Therefore, these results suggest that the Hovenia dulcis (HD) supplementation in the KOG may also prevent and treat bone loss

    A Preliminary Report of Crosslinguistic Evidence on Efficacy of Semantic-Complexity Based Naming Treatment in Korean Aphasics

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    The current study investigated the efficacy of semantic-complexity based naming treatment in Korean participants with aphasia. Results suggested that both participants showed small to medium effect sizes in the trained items. However, generalization effects were greater in the participant who received treatment on the atypical items first, than the participant who was initiated on the typical items. These results are consistent with the previous findings in English-speaking aphasic participants (Kiran & Thompson, 2003; Kiran, 2008). Preliminary findings of two Korean participants with aphasia added crosslinguistic evidence on efficacy of the semantic complexity based naming treatment
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