366 research outputs found
In Vitro Chemosensitivity Using the Histoculture Drug Response Assay in Human Epithelial Ovarian Cancer
The choice of chemotherapeutic drugs to treat patients with epithelial ovarian cancer has not depended on individual patient characteristics. We have investigated the correlation between in vitro chemosensitivity, as determined by the histoculture drug response assay (HDRA), and clinical responses in epithelial ovarian cancer. Fresh tissue samples were obtained from 79 patients with epithelial
ovarian cancer. The sensitivity of these samples to 11 chemotherapeutic agents was tested using the HDRA method according to established methods, and we analyzed the results retrospectively. HDRA showed that they were more chemosensitive to carboplatin, topotecan and belotecan, with inhibition rates of 49.2%, 44.7%, and 39.7%, respectively, than to cisplatin, the traditional drug of choice in epithelial ovarian cancer. Among the 37 patients with FIGO stage Ⅲ/Ⅳ serous adenocarcinoma
who were receiving carboplatin combined with paclitaxel, those with carboplatin-sensitive samples on HDRA had a significantly longer median disease-free interval than patients with carboplatin-
resistant samples (23.2 vs. 13.8 months, p<0.05), but median overall survival did not differ significantly
(60.4 vs. 37.3 months, p=0.621). In conclusion, this study indicates that HDRA could provide useful information for designing individual treatment strategies in patients with epithelial ovarian cancer
Observation of a linear temperature dependence of the critical current density in a Ba_{0.63}K_{0.37}BiO_3 single crystal
For a Ba_{0.63}K_{0.37}BiO_3 single crystal with T_c=31 K, H_{c1}=750 Oe at 5
K, and dimensions 3x3x1 mm^3, the temperature and field dependences of magnetic
hysteresis loops have been measured within 5-25 K in magnetic fields up to 6
Tesla. The critical current density is J_c(0)=1.5 x 10^5 A/cm^2 at zero field
and 1 x 10^5 A/cm^2 at 1 kOe at 5 K. J_c decreases exponentially with
increasing field up to 10 kOe. A linear temperature dependence of J_c is
observed below 25 K, which differs from the exponential and the power-law
temperature dependences in high-Tc superconductors including the BKBO. The
linear temperature dependence can be regarded as an intrinsic effect in
superconductors.Comment: RevTex, Physica C Vol. 341-348, 729 (2000
Exploration of Daily Rainfall Intensity Change in South Korea 1900–2010 Using Bias-Corrected ERA-20C
Synthesis of VO_2 Nanowire and Observation of the Metal-Insulator Transition
We have fabricated crystalline nanowires of VO_2 using a new synthetic
method. A nanowire synthesized at 650^oC shows the semiconducting behavior and
a nanowire at 670^oC exhibits the first-order metal-insulator transition which
is not the one-dimensional property. The temperature coefficient of resistance
in the semiconducting nanowire is 7.06 %/K at 300 K, which is higher than that
of commercial bolometer.Comment: 3 pages, 4 figures, This was presented in NANOMAT 2006 "International
workshop on nanostructed materials" on June 21-23th of 2006 in Antalya/TURKE
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