9,032 research outputs found
Incremental Few-Shot Object Detection via Simple Fine-Tuning Approach
In this paper, we explore incremental few-shot object detection (iFSD), which
incrementally learns novel classes using only a few examples without revisiting
base classes. Previous iFSD works achieved the desired results by applying
meta-learning. However, meta-learning approaches show insufficient performance
that is difficult to apply to practical problems. In this light, we propose a
simple fine-tuning-based approach, the Incremental Two-stage Fine-tuning
Approach (iTFA) for iFSD, which contains three steps: 1) base training using
abundant base classes with the class-agnostic box regressor, 2) separation of
the RoI feature extractor and classifier into the base and novel class branches
for preserving base knowledge, and 3) fine-tuning the novel branch using only a
few novel class examples. We evaluate our iTFA on the real-world datasets
PASCAL VOC, COCO, and LVIS. iTFA achieves competitive performance in COCO and
shows a 30% higher AP accuracy than meta-learning methods in the LVIS dataset.
Experimental results show the effectiveness and applicability of our proposed
method.Comment: Accepted to ICRA 202
Dendritic Cell Subsets in the Skin and Their Functional Role in Contact Hypersensitivity
Objectives: Skin is a primary epithelial organ, which protects our body from the surrounding environment. Besides physical barrier machineries, skin also contains a number of immune components that actively participate in the protective immune responses. Dendritic cells (DCs) are professional antigen-presenting cells and they are essentially required for mediating innate and adaptive immunity. Although emerging studies have demonstrated distinct resident DC subsets in the skin, their subset-specific functions still need to be elucidated. Methods: We reviewed recent works on the DC subset discrimination and specification in the mouse skin. To understand the DC subset-dependent functional diversity, we especially focused on the murine contact hypersensitivity (CHS), an experimental model of human allergic contact dermatitis. Furthermore, we discussed our recent work on the role of epidermal Langerhans cells (LCs) in CHS. Results: Murine skin harbors at least three DC subsets: (i) epidermal LCs, (ii) Langerin+ dermal DCs and (iii) Langerin- dermal DCs. Using more sophisticated cell markers, recent study has described monocyte-derived DCs in the skin. The role of each DC subset in CHS was somewhat inconsistent and redundant from study to study and needs further elaborative works for the general acceptance. Conclusion: Continuous efforts to understand the functional diversity among each cutaneous DC subset will be needed to develop the new anti-inflammatory and anti-tumor strategies by targeting relevant skin DC population in vivo
Click-aware purchase prediction with push at the top
Eliciting user preferences from purchase records for performing purchase
prediction is challenging because negative feedback is not explicitly observed,
and because treating all non-purchased items equally as negative feedback is
unrealistic. Therefore, in this study, we present a framework that leverages
the past click records of users to compensate for the missing user-item
interactions of purchase records, i.e., non-purchased items. We begin by
formulating various model assumptions, each one assuming a different order of
user preferences among purchased, clicked-but-not-purchased, and non-clicked
items, to study the usefulness of leveraging click records. We implement the
model assumptions using the Bayesian personalized ranking model, which
maximizes the area under the curve for bipartite ranking. However, we argue
that using click records for bipartite ranking needs a meticulously designed
model because of the relative unreliableness of click records compared with
that of purchase records. Therefore, we ultimately propose a novel
learning-to-rank method, called P3Stop, for performing purchase prediction. The
proposed model is customized to be robust to relatively unreliable click
records by particularly focusing on the accuracy of top-ranked items.
Experimental results on two real-world e-commerce datasets demonstrate that
P3STop considerably outperforms the state-of-the-art implicit-feedback-based
recommendation methods, especially for top-ranked items.Comment: For the final published journal version, see
https://doi.org/10.1016/j.ins.2020.02.06
Molecular methods for genomic analyses of variant PML-RARA or other RARA-related chromosomal translocations in acute promyelocytic leukemia
TO THE EDITOR: We read an interesting paper by Palta et al. in a recent issue of the Korean Journal of Hematology titled, "ZBTB16-RARA variant of acute promyelocytic leukemia with tuberculosis: a case report and review of literature" [1]. We would like to add some comments to their article and suggest additional molecular methods to confirm variant translocations in acute promyelocytic leukemia (APL)...
Effect of Angelica gigas Nakai extract on hepatic damage in rats
Purpose: To determine the antioxidant and hepatoprotective effects of decursin and decursinol angelate (D/DA) isolated from Angelica gigas Nakai (AGN).Methods: The 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity of D/DA was assessed in a rat model using blood tests, western blotting, and histopathological analyses to identify the pharmaceutical effects of D/DA on liver enzymes and liver morphology.Results: The DPPH scavenging activity of D/DA was 47.11 μg/mL. Administration of D/DA to carbon tetrachloride (CCl4)-treated rats led to a decrease (13.59 %) in the total liver mass of control rats. Decursin and decursinol angelate also lowered the levels of alanine aminotransferase (ALT) and aspartate aminotransferase (AST), but increased the concentrations of antioxidant enzymes in the liver, including catalase (CAT) and glutathione peroxidase (GPx). Histological examination revealed that D/DA also reduced hepatocellular damage in the rats.Conclusion: D/DA from AGN has significant anti-hepatotoxic and antioxidant activities, and thus, is a potential herbal drug for treating liver damage.
Keywords: Decursin, Decursinol angelate, Antihepatotoxicity, Antioxidant, Angelica gigas Naka
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