222 research outputs found
Blending in Future Space-based Microlensing Surveys
We investigate the effect of blending in future gravitational microlensing
surveys by carrying out simulation of Galactic bulge microlensing events to be
detected from a proposed space-based lensing survey. From this simulation, we
find that the contribution of the flux from background stars to the total
blended flux will be equivalent to that from the lens itself despite the
greatly improved resolution from space observations, implying that
characterizing lenses from the analysis of the blended flux would not be easy.
As a method to isolate events for which most of the blended flux is
attributable to the lens, we propose to use astrometric information of source
star image centroid motion. For the sample of events obtained by imposing a
criterion that the centroid shift should be less than three times of the
astrometric uncertainty among the events for which blending is noticed with
blended light fractions , we estimate that the contamination of
the blended flux by background stars will be less than 20% for most () of the sample events. The expected rate of these events is
events/yr, which is large enough for the statistical analysis of the lens
populations.Comment: total 6 pages, including 5 figures, ApJ, in pres
Copy Number Variation of Age-Related Macular Degeneration Relevant Genes in the Korean Population
PURPOSE: Studies that analyzed single nucleotide polymorphisms (SNP) in various genes have shown that genetic factors are strongly associated with age-related macular degeneration (AMD) susceptibility. Copy number variation (CNV) may be an additional type of genetic variation that contributes to AMD pathogenesis. This study investigated CNV in 4 AMD-relevant genes in Korean AMD patients and control subjects. METHODS: Four CNV candidate regions located in AMD-relevant genes (VEGFA, ARMS2/HTRA1, CFH and VLDLR), were selected based on the outcomes of our previous study which elucidated common CNVs in the Asian populations. Real-time PCR based TaqMan Copy Number Assays were performed on CNV candidates in 273 AMD patients and 257 control subjects. RESULTS: The predicted copy number (PCN, 0, 1, 2 or 3+) of each region was called using the CopyCaller program. All candidate genes except ARMS2/HTRA1 showed CNV in at least one individual, in which losses of VEGFA and VLDLR represent novel findings in the Asian population. When the frequencies of PCN were compared, only the gain in VLDLR showed significant differences between AMD patients and control subjects (p = 0.025). Comparisons of the raw copy values (RCV) revealed that 3 of 4 candidate genes showed significant differences (2.03 vs. 1.92 for VEGFA, p<0.01; 2.01 vs. 1.97 for CFH, p<0.01; 1.97 vs. 2.01, p<0.01 for ARMS2/HTRA1). CONCLUSION: CNVs located in AMD-relevant genes may be associated with AMD susceptibility. Further investigations encompassing larger patient cohorts are needed to elucidate the role of CNV in AMD pathogenesis
Development of Threat Evaluation Tool for Distributed Network Environment
Current information protection systems only detect and warn against individual intrusion, and are not able to provide a collective and synthesized alert message. In this paper, we propose a new Meta-IDS system which is called ``SIA System''. The SIA system can filter redundant alert messages, analyze mixed attacks using correlation alert messages from each sensor and respond to security threats quickly, after classifying them into one of four different statuses. Then we implement the SIA system and test the efficiency of it in the managed networks. Thus we confirm that the SIA system enables security managers to deal with security threats efficiently
Prevalence of sarcopenia and sarcopenic obesity in Korean adults: The Korean Sarcopenic Obesity Study (KSOS)
*Context:* Sarcopenic obesity (SO), a combination of excess weight and reduced muscle mass and/or strength, is suggested to be associated with an increased risk of adverse health outcomes. 
*Objectives:* To examine the prevalence and characteristics of Sarcopenic and SO defined by using different indices such as Appendicular Skeletal muscle Mass (ASM)/height^2^ and Skeletal Muscle Index (SMI (%): skeletal muscle mass (kg)/weight (kg) × 100) for Korean adults. 
*Methods:* 591 participants were recruited from the Korean Sarcopenic Obesity Study (KSOS) which is an ongoing prospective observational cohort study. Analysis was conducted in 526 participants (328 women, 198 men) who had complete data on body composition using Dual X-ray absorptiometry and computed tomography. 
*Results:* The prevalence of sarcopenia and SO increases with aging. Using two or more standard deviations (SD) of ASM/height^2^ below reference values from young, healthy adults as a definition of sarcopenia, the prevalence of sarcopenia and SO was 6.3% and 1.3% in men and 4.1% and 1.7% in women over 60 years of age. However, using two or more SD of SMI, the prevalence of sarcopenia and SO was 5.1% and 5.1% respectively in men and 14.2% and 12.5% respectively in women. As defined by SMI, subjects with SO had 3 times the risk of metabolic syndrome (OR = 3.03, 95% confidence interval (CI) = 1.26-7.26) and subjects with non-sarcopenic obesity had approximately 2 times the risk of metabolic syndrome (OR = 1.89, 95% CI = 1.18-3.02) compared with normal subjects. 
*Conclusion:* Obese subjects with relative sarcopenia were associated with a greater likelihood for metabolic syndrome. As Koreans were more obese and aging, the prevalence of SO and its impact on health outcomes are estimated to be rapidly grow. Further research is requested to establish the definition, cause and consequences of SO.

Formal Verification of Security Model Using SPR Tool
In this paper, formal verification methodologies and the SPR (Safety Problem Resolver) model checking tool are used for verifying a security model's safety. The SPR tool makes it possible to analyze security issues on security systems based on the access control model. To illustrate this approach, a case study of the Simple Access Control Model (SACM) is used and specific safety problems of the security model are analyzed using the SPR tool
- …