Hierarchical Text Classification as Sub-hierarchy Sequence Generation

Hierarchical text classification (HTC) is essential for various real applications. However, HTC models are challenging to develop because they often require processing a large volume of documents and labels with hierarchical taxonomy. Recent HTC models based on deep learning have attempted to incorporate hierarchy information into a model structure. Consequently, these models are challenging to implement when the model parameters increase for a large-scale hierarchy because the model structure depends on the hierarchy size. To solve this problem, we formulate HTC as a sub-hierarchy sequence generation to incorporate hierarchy information into a target label sequence instead of the model structure. Subsequently, we propose the Hierarchy DECoder (HiDEC), which decodes a text sequence into a sub-hierarchy sequence using recursive hierarchy decoding, classifying all parents at the same level into children at once. In addition, HiDEC is trained to use hierarchical path information from a root to each leaf in a sub-hierarchy composed of the labels of a target document via an attention mechanism and hierarchy-aware masking. HiDEC achieved state-of-the-art performance with significantly fewer model parameters than existing models on benchmark datasets, such as RCV1-v2, NYT, and EURLEX57K

Photoaging protective effects of BIOGF1K, a compound-K-rich fraction prepared from Panax ginseng

Background: BIOGF1K, a compound-K-rich fraction, has been shown to display anti-inflammatory activity. Although Panax ginseng is widely used for the prevention of photoaging events induced by UVB irradiation, the effect of BIOGF1K on photoaging has not yet been examined. In this study, we investigated the effects of BIOGF1K on UVB-induced photoaging events. Methods: We analyzed the ability of BIOGF1K to prevent UVB-induced apoptosis, enhance matrix metalloproteinase (MMP) expression, upregulate anti-inflammatory activity, reduce sirtuin 1 expression, and melanin production using reverse transcription-polymerase chain reaction, melanin content assay, tyrosinase assay, and flow cytometry. We also evaluated the effects of BIOGF1K on the activator protein-1 signaling pathway, which plays an important role in photoaging, by immunoblot analysis and luciferase reporter gene assays. Results: Treatment of UVB-irradiated NIH3T3 fibroblasts with BIOGF1K prevented UVB-induced cell death, inhibited apoptosis, suppressed morphological changes, reduced melanin secretion, restored the levels of type I procollagen and sirtuin 1, and prevented mRNA upregulation of MMP-1, MMP-2, and cyclo-oxygenase-2; these effects all occurred in a dose-dependent manner. In addition, BIOGF1K markedly reduced activator-protein-1-mediated luciferase activity and decreased the activity of mitogen-activated protein kinases (extracellular response kinase, p38, and C-Jun N-terminal kinase). Conclusion: Our results strongly suggest that BIOGF1K has anti-photoaging activity and that BIOGF1K could be used in anti-aging cosmeceutical preparations