DEVELOPMENT OF HIGH-THROUGHPUT NMR RF RECEIVER USING FPGA IP CORES

In NMR research, the signal acquisition instrument needs to fulfill high-speed, and high-throughput data collection. The modern NMR receivers are required to process signals through multiple-channels leveraging Software Defined Radio (SDR) logics. In order to support large amount of data inputs utilizing multiple channels, the device needs to speedily handle stream of input data within device's Onboard memory (RAM) and construct non-overflowing buffer to ensure flawless data transfer from analog-to-digital convertor (ADC). Parallel data handling techniques in FPGA is an essential component for NMR applications, because multiple process engine in FPGA digital logic ensures high processing speed. Direct-Memory-Access (DMA) function implemented in FPGA would greatly improve the data transfer rate. This would allow the NMR receiver to operate the system in real-time. In this research work, we investigate a method to utilize the FPGA's Digital Down Conversion (DDC) logic to control the data flow in a versatile way. Furthermore, we examine methods in acquisition software to thoroughly access implemented FPGA logics utilizing LabVIEW software. Throughout this research, we investigate a software design pattern that would maximize its performance in parallel processing. Software architecture such state-machine, and Actor Framework would be examined to organize the device APIs

Retention Issues of Mature Students: A Comparative Higher Education Analysis of Programs in the United States and Ireland

Retention of students is an issue that challenges colleges and universities around the world and South Africa is no exception. A comparative look at Ireland and the United States shows that there are many similar tools used to retain mature students, and, at the same time, many different ones are used depending on particular situations. A brief retention literature review dealing with mature students is provided as well as examples of retention strategies used in both countries. While these strategies may not fit for South Africa, they may serve as a point of departure for similar activities there

Bacteria and the Aging and Longevity of Caenorhabditis elegans

The molecular genetic analysis of longevity of Caenorhabditis elegans has yielded fundamental insights into evolutionarily conserved pathways and processes governing the physiology of aging. Recent studies suggest that interactions between C. elegans and its microbial environment may influence the aging and longevity of this simple host organism. Experimental evidence supports a role for bacteria in affecting longevity through distinct mechanisms—as a nutrient source, as a potential pathogen that induces double-edged innate immune and stress responses, and as a coevolved sensory stimulus that modulates neuronal signaling pathways regulating longevity. Motivating this review is the anticipation that the molecular genetic dissection of the integrated host immune, stress, and neuroendocrine responses to microbes in C. elegans will uncover basic insights into the cellular and organismal physiology that governs aging and longevity.National Institute of General Medical Sciences (U.S.)Ellison Medical Foundatio

A study of convection velocities in a zero pressure gradient turbulent boundary layer

Time-resolved DPIV measurements performed in wall parallel planes at several wall normal locations in a turbulent boundary layer (TBL) are used to illuminate the distribution of wall parallel velocities in a three-dimensional energy spectrum over streamwise, spanwise, and temporal wavelengths. To our knowledge, this is the first time this type of spectral distribution has been reported. Slices of the 3D spectrum can give insight into the propagation of different scales in the ow as well as the streamwise and spanwise extent of dominant scales. Measurements were performed at three wall normal locations, y^+ = 34; 108; and 278, in a zero pressure gradient TBL at Re_τ = 470 . Two high speed cameras placed side-by-side in the streamwise direction give a 10δ streamwise field of view with a time step of Δt^+ = 0:5 between consecutive fields. Far from the wall the convection velocities of all scales are very close to the local mean velocity in agreement with the work of Dennis and Nickels, while at y^+ = 34 it was found that all measured scales in the flow convect faster than the local mean in agreement with Krogstad et. al. The variation of the convection velocity with scale and distance from the wall will be discussed

Multicritical Points of Potts Spin Glasses on the Triangular Lattice

We predict the locations of several multicritical points of the Potts spin glass model on the triangular lattice. In particular, continuous multicritical lines, which consist of multicritical points, are obtained for two types of two-state Potts (i.e., Ising) spin glasses with two- and three-body interactions on the triangular lattice. These results provide us with numerous examples to further verify the validity of the conjecture, which has succeeded in deriving highly precise locations of multicritical points for several spin glass models. The technique, called the direct triangular duality, a variant of the ordinary duality transformation, directly relates the triangular lattice with its dual triangular lattice in conjunction with the replica method.Comment: 18 pages, 2, figure

Vitamin A Metabolism by Dendritic Cells Triggers an Antimicrobial Response against Mycobacterium tuberculosis.

Epidemiological evidence correlates low serum vitamin A (retinol) levels with increased susceptibility to active tuberculosis (TB); however, retinol is biologically inactive and must be converted into its bioactive form, all-trans retinoic acid (ATRA). Given that ATRA triggers a Niemann-Pick type C2 (NPC2)-dependent antimicrobial response against Mycobacterium tuberculosis, we investigated the mechanism by which the immune system converts retinol into ATRA at the site of infection. We demonstrate that granulocyte-macrophage colony-stimulating factor (GM-CSF)-derived dendritic cells (DCs), but not macrophages, express enzymes in the vitamin A metabolic pathway, including aldehyde dehydrogenase 1 family, member a2 (ALDH1A2) and short-chain dehydrogenase/reductase family, member 9 (DHRS9), enzymes capable of the two-step conversion of retinol into ATRA, which is subsequently released from the cell. Additionally, mRNA and protein expression levels of ALDH1A2 and DC marker CD1B were lower in tuberculosis lung tissues than in normal lung. The conditioned medium from DCs cultured with retinol stimulated antimicrobial activity from M. tuberculosis-infected macrophages, as well as the expression of NPC2 in monocytes, which was blocked by specific inhibitors, including retinoic acid receptor inhibitor (RARi) or N,N-diethylaminobenzaldehyde (DEAB), an ALDH1A2 inhibitor. These results indicate that metabolism of vitamin A by DCs transactivates macrophage antimicrobial responses.IMPORTANCE Tuberculosis (TB) is the leading cause of death by a single infectious agent worldwide. One factor that contributes to the success of the microbe is the deficiency in immunomodulatory nutrients, such as vitamin A (retinol), which are prevalent in areas where TB is endemic. Clinical trials show that restoration of systemic retinol levels in active TB patients is ineffective in mitigating the disease; however, laboratory studies demonstrate that activation of the vitamin A pathway in Mycobacterium tuberculosis-infected macrophages triggers an antimicrobial response. Therefore, the goal of this study was to determine the link between host retinol levels and retinoic acid-mediated antimicrobial responses against M. tuberculosis By combining established in vitro models with in situ studies of lung tissue from TB patients, this study demonstrates that the innate immune system utilizes transcellular metabolism leading to activation between dendritic cells and macrophages as a means to combat the pathogen

Negotiation in strategy making teams : group support systems and the process of cognitive change

This paper reports on the use of a Group Support System (GSS) to explore at a micro level some of the processes manifested when a group is negotiating strategy-processes of social and psychological negotiation. It is based on data from a series of interventions with senior management teams of three operating companies comprising a multi-national organization, and with a joint meeting subsequently involving all of the previous participants. The meetings were concerned with negotiating a new strategy for the global organization. The research involved the analysis of detailed time series data logs that exist as a result of using a GSS that is a reflection of cognitive theory

A retrospective observational study of traumatic orthopaedic: related infections in Cambodia

Background: The objective of this study was to establish the type of microbiology along with antimicrobial resistance related to orthopedic related trauma infections in this area in order to help guide diagnosis and treatment regimens.Methods:This study evaluated the microbial etiology of orthopedic-related infections (ORI) between September 2015 and September 2016 in three tertiary hospitals in Phnom Penh, Cambodia. Clinical records were for clinical features and demographics. Standard laboratory bacteriology was used to recover, identified and perform antibiotic susceptibility testing (AST) by disk diffusion or broth microdilution.Results:119 patients were categorized as ORI cases. In the cases identified, median interquartile range (IQR) age was 38 (IQR: 26-46) years and 80.0% were male. Of the 119 ORI cases, a total of 156 bacterial strains were recovered, identified and after review, 128 of these pathogenic bacterial strains underwent AST. Among the gram-positive pathogens, the following susceptibilities were as follows: Staphylococcus aureus (n=57) (Methicillin-resistant S. aureus (n=35; 61.4%), (Methicillin‐sensitive S. aureus (n=22; 38.6%)), coagulase-negative staphylococcus (all MS-CoNS; n=6) and four isolates of Enterococcus sp. (non-VRE). A total of 44 gram-negative pathogens were recovered and AST was performed. Among these 44, a total of nine extended-spectrum beta-lactamase (ESBL) producing strains (20.5%) were discovered including Escherichia coli (n=8), Klebsiella pneumoniae (n=1) and carbapenemase-resistant Enterobacteriaceae (CRE) (Morganella morganii). In addition, a single E. coli isolate contained both the ESBL and CRE genotypes was noted.Conclusions:This data suggests that ORI rates in Cambodia appear to be comparable to other studies in the literature. However, further studies need to be done in order to establish definitive data related to orthopedic infections in the region