Moduli trapping mechanism in modular flavor symmetric models

We discuss how the moduli in modular flavor symmetric models dynamically select enhanced symmetry points at which the residual modular symmetry renders extra matter fields massless. The moduli dynamics non-perturbatively produces the extra matter particles, which gives (time-dependent) effective potential that traps the moduli to enhanced symmetry points. We show analytic estimates of particle production rate consistent with numerical results, and the dynamics of moduli based on the analytic estimates.Comment: 35 pages, 14 figure

Statistics of correlated percolation in a bacterial community

Signal propagation over long distances is a ubiquitous feature of multicellular communities, but cell-to-cell variability can cause propagation to be highly heterogeneous. Simple models of signal propagation in heterogenous media, such as percolation theory, can potentially provide a quantitative understanding of these processes, but it is unclear whether these simple models properly capture the complexities of multicellular systems. We recently discovered that in biofilms of the bacterium Bacillus subtilis, the propagation of an electrical signal is statistically consistent with percolation theory, and yet it is reasonable to suspect that key features of this system go beyond the simple assumptions of basic percolation theory. Indeed, we find here that the probability for a cell to signal is not independent from other cells as assumed in percolation theory, but instead is correlated with its nearby neighbors. We develop a mechanistic model, in which correlated signaling emerges from cell division, phenotypic inheritance, and cell displacement, that reproduces the experimentally observed correlations. We find that the correlations do not significantly affect the spatial statistics, which we rationalize using a renormalization argument. Moreover, the fraction of signaling cells is not constant in space, as assumed in percolation theory, but instead varies within and across biofilms. We find that this feature lowers the fraction of signaling cells at which one observes the characteristic power-law statistics of cluster sizes, consistent with our experimental results. We validate the model using a mutant biofilm whose signaling probability decays along the propagation direction. Our results reveal key statistical features of a correlated signaling process in a multicellular community. More broadly, our results identify extensions to percolation theory that do or do not alter its predictions and may be more appropriate for biological systems.P50 GM085764 - NIGMS NIH HHS; Howard Hughes Medical Institute; R01 GM121888 - NIGMS NIH HHSPublished versio

Quark hierarchical structures in modular symmetric flavor models at level 6

We study modular symmetric quark flavor models without fine-tuning. Mass matrices are written in terms of modular forms, and modular forms in the vicinity of the modular fixed points become hierarchical depending on their residual charges. Thus modular symmetric flavor models in the vicinity of the modular fixed points have a possibility to describe mass hierarchies without fine-tuning. Since describing quark hierarchies without fine-tuning requires $Z_n$ residual symmetry with $n\geq 6$, we focus on $\Gamma_6$ modular symmetry in the vicinity of the cusp $\tau=i\infty$ where $Z_6$ residual symmetry remains. We use only modular forms belonging to singlet representations of $\Gamma_6$ to make our analysis simple. Consequently, viable quark flavor models are obtained without fine-tuning.Comment: 29 page

Modular symmetry in magnetized T2gT^{2g} torus and orbifold models

We study the modular symmetry in magnetized $T^{2g}$ torus and orbifold models. The $T^{2g}$ torus has the modular symmetry $\Gamma_{g}=Sp(2g,\mathbb{Z})$. Magnetic flux background breaks the modular symmetry to a certain normalizer $N_{g}(H)$. We classify remaining modular symmetries by magnetic flux matrix types. Furthermore, we study the modular symmetry for wave functions on the magnetized $T^{2g}$ and certain orbifolds. It is found that wave functions on magnetized $T^{2g}$ as well as its orbifolds behave as the Siegel modular forms of weight $1/2$ and $\widetilde{N}_{g}(H,h)$, which is the metapletic congruence subgroup of the double covering group of $N_{g}(H)$, $\widetilde{N}_{g}(H)$. Then, wave functions transform non-trivially under the quotient group, $\widetilde{N}_{g,h}=\widetilde{N}_{g}(H)/\widetilde{N}_{g}(H,h)$, where the level $h$ is related to the determinant of the magnetic flux matrix. Accordingly, the corresponding four-dimensional (4D) chiral fields also transform non-trivially under $\widetilde{N}_{g,h}$ modular flavor transformation with modular weight $-1/2$. We also study concrete modular flavor symmetries of wave functions on magnetized $T^{2g}$ orbifolds.Comment: 53 page

Zero-modes in magnetized T6/ZNT^6/\mathbb{Z}_N orbifold models through Sp(6,Z)Sp(6,\mathbb{Z}) modular symmetry

We study of fermion zero-modes on magnetized $T^6/\mathbb{Z}_N$ orbifolds. In particular, we focus on non-factorizable orbifolds, i.e. $T^6/\mathbb{Z}_7$ and $T^6/\mathbb{Z}_{12}$ corresponding to $SU(7)$ and $E_6$ Lie lattices respectively. The number of degenerated zero-modes corresponds to the generation number of low energy effective theory in four dimensional space-time. We find that three-generation models preserving 4D $\mathcal{N}=1$ supersymmetry can be realized by magnetized $T^6/\mathbb{Z}_{12}$, but not by $T^6/\mathbb{Z}_7$. We use $Sp(6,\mathbb{Z})$ modular transformation for the analyses.Comment: 37 pages, 2 figure

Sp(6,Z)Sp(6,Z) modular symmetry in flavor structures: quark flavor models and Siegel modular forms for Δ~(96)\widetilde{\Delta}(96)

We study an approach to construct Siegel modular forms from $Sp(6,Z)$. Zero-mode wave functions on $T^6$ with magnetic flux background behave Siegel modular forms at the origin. Then $T$-symmetries partially break depending on the form of background magnetic flux. We study the background such that three $T$-symmetries $T_I$, $T_{II}$ and $T_{III}$ as well as the $S$-symmetry remain.Consequently, we obtain Siegel modular forms with three moduli parameters $(\omega_1,\omega_2,\omega_3)$, which are multiplets of finite modular groups. We show several examples. As one of examples, we study Siegel modular forms for $\widetilde{\Delta}(96)$ in detail. Then, as a phenomenological applicantion, we study quark flavor models using Siegel modular forms for $\widetilde{\Delta}(96)$. Around the cusp, $\omega_1=i\infty$, the Siegel modular forms have hierarchical values depending on their $T_I$-charges. We show the deviation of $\omega_1$ from the cusp can generate large quark mass hierarchies without fine-tuning. Furthermore CP violation is induced by deviation of $\omega_2$ from imaginary axis.Comment: 54 page

Quark mass hierarchies and CP violation in A4×A4×A4A_4\times A_4\times A_4 modular symmetric flavor models

We study $A_4 \times A_4 \times A_4$ modular symmetric flavor models to realize quark mass hierarchies and mixing angles without fine-tuning. Mass matrices are written in terms of modular forms. At modular fixed points $\tau = i\infty$ and $\omega$, $A_4$ is broken to $Z_3$ residual symmetry. When the modulus $\tau$ is deviated from the fixed points, modular forms show hierarchies depending on their residual charges. Thus, we obtain hierarchical structures in mass matrices. Since we begin with $A_4\times A_4 \times A_4$, the residual symmetry is $Z_3 \times Z_3 \times Z_3$ which can generate sufficient hierarchies to realize quark mass ratios and absolute values of the CKM matrix $|V_{\textrm{CKM}}|$ without fine-tuning. Furthermore, CP violation is studied. We present necessary conditions for CP violation caused by the value of $\tau$. We also show possibilities to realize observed values of the Jarlskog invariant $J_{\textrm{CP}}$, quark mass ratios and CKM matrix $|V_{\textrm{CKM}}|$ simultaneously, if $\mathcal{O}(10)$ adjustments in coefficients of Yukawa couplings are allowed.Comment: 41 pages, 3 figure

Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation

Anti-resorptive drugs are widely used for the treatment of osteoporosis, but excessive inhibition of osteoclastogenesis can suppress bone turnover and cause the deterioration of bone quality. Sialic acid-binding immunoglobulin-like lectin 15 (Siglec-15) is a transmembrane protein expressed on osteoclast precursor cells and mature osteoclasts. Siglec-15 regulates proteins containing immunoreceptor tyrosine-based activation motif (ITAM) domains, which then induce nuclear factor of activated T-cells 1 (NFATc1), a master transcription factor of osteoclast differentiation. Anti-Siglec-15 antibody modulates ITAM signaling in osteoclast precursors and inhibits the maturation of osteoclasts in vitro. However, in situ pharmacological effects, particularly during postmenopausal osteoporosis, remain unclear. Here, we demonstrated that anti-Siglec-15 antibody treatment protected against ovariectomy-induced bone loss by specifically inhibiting the generation of multinucleated osteoclasts in vivo. Moreover, treatment with anti-Siglec-15 antibody maintained bone formation to a greater extent than with risedronate, the first-line treatment for osteoporosis. Intravital imaging revealed that anti-Siglec-15 antibody treatment did not cause a reduction in osteoclast motility, whereas osteoclast motility declined following risedronate treatment. We evaluated osteoclast activity using a pH-sensing probe and found that the bone resorptive ability of osteoclasts was lower following anti-Siglec-15 antibody treatment compared to after risedronate treatment. Our findings suggest that anti-Siglec-15 treatment may have potential as an anti-resorptive therapy for osteoporosis, which substantially inhibits the activity of osteoclasts while maintaining physiological bone coupling.Tsukazaki H., Kikuta J., Ao T., et al. Anti-Siglec-15 antibody suppresses bone resorption by inhibiting osteoclast multinucleation without attenuating bone formation. Bone 152, 116095 (2021); https://doi.org/10.1016/j.bone.2021.116095