Mechanical properties of the rigid and hydrostatic skeletons of molting blue crabs, Callinectes sapidus Rathbun

Molting in crustaceans involves significant changes in the structure and function of the exoskeleton as the old cuticle is shed and a new one is secreted. The flimsy new cuticle takes several days to harden and during this time crabs rely on a hydrostatic skeletal support system for support and movement. This change from a rigid to a hydrostatic skeletal support mechanism implies correlated changes in the function, and thus mechanical properties, of the cuticle. In particular, it must change from primarily resisting compression, bending and torsional forces to resisting tension. This study was designed to explore the changes in the mechanical properties of the crustacean cuticle as the animals switch between two distinct skeletal support mechanisms. Samples of cuticle were removed from blue crabs

Animal Tracks Northern Forest Action Pack

Welcome to Animal Tracks®, a classroom education program of the National Wildlife Federation focusing on teacher training and environmental education resources. In Animal Tracks materials, the animals and their tracks lead educators and students on an exploration of conservation issues. Thank you for using this Action Pack, our newest resource. We hope you find the Action Packs useful and as a \u27\u27work-in-progress,\u27\u27 we welcome any comments you might have for improvements. As you turn the page you\u27ll see our questionnaire. Please take a minute to fill it out and put it in the mail. We\u27ll include you on our mailing list and you\u27ll get invitations to any Animal Tracks educator workshops that we hold in your area as well as the latest information on Animal Tracks programs and materials. Animal Tracks Workshops are a large part of the Animal Tracks program. The Action Pack series was originally developed as our teacher training module. The workshops are designed to help teachers easily fit environmental and conservation issues into their lesson plans across the curriculum. Animal Tracks workshops emphasize learning by doing and include an interactive discussion of how to successfully incorporate action projects into learning. Animal Tracks has educator materials and information available online at http://www.nwf.orglatracks including the Water and Habitat Action Packs, Current Events Hotline, information about NWF\u27s EarthTomorrow program for Detroit area schools, Environmental Education Online Conference, Animal Tracks Workshop schedule, and Animal Tracks Online classroom activities. There are also Animal Tracks kids\u27 pages at http://www.nwf.orglnwflkids/ with our Cool Tour of the Environment, Ranger Rick site, resources in Spanish, games, and more fun. The next pages of the Action Pack are a questionnaire and an explanation about how to effectively use the Animal Tracks Action Packs. Again, we hope you find this a valuable resource and be sure to check out all the Animal Tracks Action Pack titles

Animal Tracks Wetlands Action Pack

Welcome to Animal Tracks®, a classroom education program of the National Wildlife Federation focusing on teacher training and environmental education resources. In Animal Tracks materials, the animals and their tracks lead educators and students on an exploration of conservation issues. Thank you for using this Action Pack, our newest resource. We hope you find the Action Packs useful and as a work-in-progress, we welcome any comments you might have for I improvements. As you turn the page you\u27ll see our questionnaire. Please take a minute to fill it out and put it in the mail. We\u27ll include you on our mailing list and you\u27ll get invitations to any Animal Tracks educator workshops that we hold in your area as well as the latest information on Animal Tracks programs and materials. Animal Tracks Workshops are a large part of the Animal Tracks program. The Action Pack series was originally developed as our teacher training module. The workshops are designed to help teachers easily fit environmental and conservation issues into their lesson plans across the curriculum. Animal Tracks workshops emphasize learning by doing and include an interactive discussion of how to successfully incorporate action projects into learning. Animal Tracks has educator materials and information available online at http://www.nwf.org/atracks including the Water and Habitat Action Packs, Current Events Hotline, information about NWF\u27s EarthTomorrow® program for Detroit area schools, Environmental Education Online Conference, Animal Tracks Workshop schedule, and Animal Tracks Online classroom activities. There are also Animal Tracks kids\u27 pages at http://www.nwf.org/nwf/kids/ with our Cool Tour o/the Environment, Ranger Rick® site, resources in Spanish, games, and more fun. The next pages of the Action Pack are a questionnaire and an explanation about how to effectively use the Animal Tracks Action Packs. Again, we hope you find this a valuable resource and be sure to check out all the Animal Tracks Action Pack titles

Management of Hypertensive Emergencies in Pediatrics

As hypertension becomes more prevalent in the pediatric population, clinicians are more likely to encounter hypertensive emergencies in children, which require pharmacists and physicians to be educated on the therapeutic options for these emergencies. However, the strict governmental requirements on the testing of these drugs in pediatric patients have limited the amount of available evidence on which to base clinical decisions. This review will highlight the available evidence and preferred treatment options for the management of pediatric hypertensive emergencies

Animal Tracks Habitat Action Pack

Welcome to Animal Tracks ®, a classroom education program of the National Wildlife Federation focusing on teacher training and environmental education resources. In Animal Tracks materials, the animals and their tracks lead educators and students on an exploration of conservation issues. Thank you for using this Action Pack, our newest resource. We hope you find the Action Packs useful and because this is a work-in-progress, we welcome any comments you might have for improvements. As you turn the page you\u27ll see our questionnaire. Please take a minute to fill it out and put it in the mail. We\u27ll include you on our mailing list and you\u27ll get invitations to any Animal Tracks educator workshops that we hold in your area as well as the latest information on Animal Tracks programs and materials. Animal Tracks Worksbops are a large part of the Animal Tracks program. The Action Pack series was originally developed as our teacher training module. The workshops are designed to help teachers easily fit environmental and conservation issues into their lesson plans across the curriculum. Animal Tracks workshops emphasize learning by doing and include an interactive discussion of how to successfully incorporate action projects into learning. Animal Tracks has educator materials and information available online at bttp://www.nwf.org/atracks including the Water and Habitat Action Packs, Current Events Hotline, information about NWF\u27s EarthTomorrow ® program for Detroit area schools, Environmental Education Online Conference, Animal Tracks Workshop schedule, and Animal Tracks Online classroom activities. There are also Animal Tracks kids\u27 pages at http://www.nwf.org/nwf/kids/ with our Cool Tour of the Environment, Ranger Rick ® site, resources in Spanish, games, and more fun. The next pages of the Action Pack are a questionnaire and an explanation about how to effectively use the Animal Tracks Action Packs. Again, we hope you find this a valuable resource and be sure to check out all the Animal Tracks Action Pack titles

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

How projects co-create value with stakeholders:the role of ideology and inquiry in spanning the temporary-permanent boundary

Abstract Projects transform organisational processes as they deliver physical artefacts and spaces. Yet in the existing literature, there is relatively little attention to how project delivery professionals engage members of an organisation to co-create value. Building on research on stakeholders and organisational boundaries, an empirical study of the renewal of a large Finnish hospital is used to develop new insight into value co-creation between temporary and permanent forms of organisation. In this hospital case study, we find a framing ideology that supports value co-creation is provided by the project practitioners’ commitment to ‘service design’, and an enquiry that enrols organisational stakeholders’ participation and reveals temporal tensions at the temporary-permanent boundary. As the emergent temporal tensions are managed, ideas flow across the boundary and new artefacts and spaces are designed by the project team concurrently with, and are informed by, the implementation of new organisational processes. This study’s contribution is to explain how project delivery professionals use ideology and enquiry to engage and co-create value with organisational participants

The Emerging Role of Ticagrelor in Acute Coronary Syndromes

Antiplatelet therapy has become a mainstay in the treatment of acute coronary syndromes (ACS). Until recently, options were somewhat limited when it came to individualizing drug selection. Plavix® (clopidogrel) has been successfully used for many years but requires activation by CYP enzymes. Depending on an individual patient\u27s genetic makeup, function of these CYP enzymes may be altered, which may increase the risk for clots. The recent approval of Effient® (prasugrel) and Brilinta® (ticagrelor) has provided physicians and pharmacists with more options and may hopefully lead to improved clinical outcomes. Ticagrelor specifically exhibits clinically different pharmacologic characteristics that require twice daily dosing, but also allows for faster onset and offset, as well as more predictable platelet inhibition as compared to dopidogrel. Additional postmarketing surveillance and treatment guidelines will hopefully continue to guide appropriate selection of antiplatelet therapies