Direct Distances to Cepheids in the Large Magellanic Cloud: Evidence for a Universal Slope of the Period-Luminosity Relation up to Solar Abundance

We have applied the infrared surface brightness (ISB) technique to derive distances to 13 Cepheids in the LMC which span a period range from 3 to 42 days. From the absolute magnitudes of the variables calculated from these distances, we find that the LMC Cepheids define tight period-luminosity relations in the V, I, W, J and K bands which agree exceedingly well with the corresponding Galactic PL relations derived from the same technique, and are significantly steeper than the LMC PL relations in these bands observed by the OGLE-II Project in V, I and W, and by Persson et al. in J and K. We find that the tilt-corrected true distance moduli of the LMC Cepheids show a significant dependence on period, which hints at a systematic error in the ISB technique related to the period of the stars. We identify as the most likely culprit the p-factor which converts the radial into pulsational velocities; our data imply a much steeper period dependence of the p-factor than previously thought, and we derive p=1.58 (+/-0.02) -0.15 (+/-0.05) logP as the best fit from our data, with a zero point tied to the Milky Way open cluster Cepheids. Using this revised p-factor law, the period dependence of the LMC Cepheid distance moduli disappears, and at the same time the Milky Way and LMC PL relations agree among themselves, and with the directly observed LMC PL relations, within the 1 sigma uncertainties. Our main conclusion is that the previous, steeper Galactic PL relations were caused by an erroneous calibration of the p-factor law, and that there is now evidence that the slope of the Cepheid PL relation is independent of metallicity up to solar metallicity, in both optical, and near-infrared bands.Comment: ApJ accepte

Evidence for a Universal Slope of the Period-Luminosity Relation from Direct Distances to Cepheids in the LMC

We have applied the infrared surface brightness (ISB) technique to derive distances to 13 Cepheid variables in the LMC which have periods from 3-42 days. The corresponding absolute magnitudes define PL relations in VIWJK bands which agree exceedingly well with the corresponding Milky Way relations obtained from the same technique, and are in significant disagreement with the observed LMC Cepheid PL relations, by OGLE-II and Persson et al., in these bands. Our data uncover a systematic error in the p-factor law which transforms Cepheid radial velocities into pulsational velocities. We correct the p-factor law by requiring that all LMC Cepheids share the same distance. Re-calculating all Milky Way and LMC Cepheid distances with the revised p-factor law, we find that the PL relations from the ISB technique both in LMC and in the Milky Way agree with the OGLE-II and Persson et al. LMC PL relations, supporting the conclusion of no metallicity effect on the slope of the Cepheid PL relation in optical/near infrared bands.Comment: 4 pages, to appear in the proceedings of the "Stellar Pulsation and Evolution" conference, Monte Porzio Catone, June 200

R5X4 HIV-1 coreceptor use in primary target cells: implications for coreceptor entry blocking strategies

Entry coreceptor use by HIV-1 plays a pivotal role in viral transmission, pathogenesis and disease progression. In many HIV-1 infected individuals, there is an expansion in coreceptor use from CCR5 to include CXCR4, which is associated with accelerated disease progression. While targeting HIV-1 envelope interactions with coreceptor during viral entry is an appealing approach to combat the virus, the methods of determining coreceptor use and the changes in coreceptor use that can occur during disease progression are important factors that may complicate the use of therapies targeting this stage of HIV-1 replication. Indicator cells are typically used to determine coreceptor use by HIV-1 in vitro, but the coreceptors used on these cells can differ from those used on primary cell targets. V3 based genetic sequence algorithms are another method used to predict coreceptor use by HIV-1 strains. However, these algorithms were developed to predict coreceptor use in cell lines and not primary cells and, furthermore, are not highly accurate for some classes of viruses. This article focuses on R5X4 HIV-1, the earliest CXCR4-using variants, reviewing the pattern of coreceptor use on primary CD4+ lymphocytes and macrophages, the relationship between primary cell coreceptor use and the two principal approaches to coreceptor analysis (genetic prediction and indicator cell phenotyping), and the implications of primary cell coreceptor use by these strains for treatment with a new class of small molecule antagonists that inhibit CCR5-mediated entry. These are important questions to consider given the development of new CCR5 blocking therapies and the prognosis associated with CXCR4 use

Propranolol blocks ventricular refractory period changes with orthostatic stress in humans

The purpose of this study was to test the hypothesis that orthostatic stress shortens the right ventricular effective refractory period by reflex activation of beta-adrenergic receptors. Twelve patients undergoing electrophysiologic testing for standard clinical indications were studied. After a full electrophysiologic study, patients underwent graded lower body negative pressure before and after administration of either propranolol (0.2 mg/kg intravenously) in Group I or atropine (0.035 mg/kg intravenously) in Group II.Before the addition of drugs, lower body negative pressure produced decreases in systolic blood pressure and significant increases in sinus rate. The effective refractory period shortened from 214 ± 8 (mean ± SEM) to 206 ± 7 ms at −40 cm H2O and to 197 ± 4 ms at −60 cm H2O lower body negative pressure. After propranolol, Group I patients had no change in right ventricular effective refractory period despite similar changes in sinus rate and systolic blood pressure. In Group II patients, atropine did not alter effective refractory period responses to lower body negative pressure.Thus, reflex adjustments to orthostatic stress result in shortening of right ventricular effective refractory period mediated by way of beta-adrenergic mechanisms. These findings constitute the first evidence that sympathetic influences mobilized by the body can directly modulate ventricular electrophysiologic changes

Magnetic form factor of SrFe2_2As2_2

Neutron diffraction measurements have been carried out to investigate the magnetic form factor of the parent SrFe2As2 system of the iron-based superconductors. The general feature is that the form factor is approximately isotropic in wave vector, indicating that multiple d-orbitals of the iron atoms are occupied as expected based on band theory. Inversion of the diffraction data suggests that there is some elongation of the spin density toward the As atoms. We have also extended the diffraction measurements to investigate a possible jump in the c-axis lattice parameter at the structural phase transition, but find no detectable change within the experimental uncertainties

High Mass Triple Systems: The Classical Cepheid Y Car

We have obtained an HST STIS ultraviolet high dispersion Echelle mode spectrum the binary companion of the double mode classical Cepheid Y Car. The velocity measured for the hot companion from this spectrum is very different from reasonable predictions for binary motion, implying that the companion is itself a short period binary. The measured velocity changed by 7 km/ s during the 4 days between two segments of the observation confirming this interpretation. We summarize "binary" Cepheids which are in fact members of triple system and find at least 44% are triples. The summary of information on Cepheids with orbits makes it likely that the fraction is under-estimated.Comment: accepted by A