Metabolic parameters of the platelet concentrates.

<p>Metabolic parameters of the platelet concentrates.</p

Effect of 10-day storage on platelet activation, measured by light transmission aggregometry (LTA).

<p>Aggregometry was measured in response to 10 μmol/L adenosine diphosphate (ADP, panel A), 4 μg/ml collagen (panel B) and 30 μmol/L thrombin receptor-activating peptide (TRAP-14, panel C). Light transmission in platelet concentrates (PCs) compared to autologous platelet poor plasma is expressed as percentage of maximal aggregation. Data are expressed as mean±SD and a dashed line was set on mean day 2—2SD. * = P<0.01, ** = P<0.001 compared to day 2.</p

Effect of hypoxia on oxygen saturation, heart rate, blood pressure, altitude symptom score and paracetamol intake.

<p>Data are medians with interquartile ranges (A-D) or mean with SEM (E-F). *p<0.05.</p

Basic characteristics of both groups at 50 m (day 1).

<p>Data are mean values ± SD.</p

Thrombin generation in plasma.

<p>Thrombin generation was started with 1 pM TF, 4 μM phospholipid vesicles and 16.7 mM CaCl₂. The parameters depicted are the Peak height (A), ETP (B), Lagtime (C) and Time-to-peak (D). Data are medians with interquartile ranges.</p

Whole blood thrombin generation parameters of the resting control group.

<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl₂. The parameters depicted are the Peak height (A), ETP (B), Lagtime (C) and Time-to-peak (D). Data are median percentages normalized to day 1 with interquartile ranges (N = 7).</p

Thrombin generation in whole blood.

<p>Thrombin generation was started with 0.5 pM TF and 16.7 mM CaCl₂. The parameters depicted are the Peak height (A), ETP (B), Lagtime (C), Time-to-peak (D) and Velocity index (E). Data are medians with interquartile ranges.</p

Fibrinogen (A), von Willebrand factor (B) and FVIII (C) levels in plasma.

<p>Data are medians with interquartile ranges. *p<0.05.</p