26 research outputs found

    A Tool to Recover Scalar Time-Delay Systems from Experimental Time Series

    Full text link
    We propose a method that is able to analyze chaotic time series, gained from exp erimental data. The method allows to identify scalar time-delay systems. If the dynamics of the system under investigation is governed by a scalar time-delay differential equation of the form dy(t)/dt=h(y(t),y(tβˆ’Ο„0))dy(t)/dt = h(y(t),y(t-\tau_0)), the delay time Ο„0\tau_0 and the functi on hh can be recovered. There are no restrictions to the dimensionality of the chaotic attractor. The method turns out to be insensitive to noise. We successfully apply the method to various time series taken from a computer experiment and two different electronic oscillators

    ΠžΡ‚Ρ€Π°ΡΠ»Π΅Π²Ρ‹Π΅ особСнности примСнСния ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ прогнозирования банкротства прСдприятия

    Get PDF
    The aim of the research is to develop the methodology of bankruptcy prediction applying the specified statutory values of the existing models with a glance to company’s industry and developing the author’s prediction model. Initially authors estimated the forecast accuracy of the existing models for the enterprises of 8 industries. Using CART (Classification And Regression Tree) methodology the original statutory values of the models were specified for every industry under research. The calculated statutory values demonstrated the high level of prediction accuracy and balanced the indicators of accuracy for bankrupt and non-bankrupt companies. The indicators with the maximum level of significance for bankruptcy prediction were selected from all the models. They formed a basis for a new developed model, which has demonstrated the high level of prediction accuracy on a sample under research. The statutory values for the new model were also developed.The implementation of the research’s results will increase the efficiency of bankruptcy prediction and low the number of bankrupt companies.ИсслСдованиС прСдпринято для ΡΠΎΠ²Π΅Ρ€ΡˆΠ΅Π½ΡΡ‚Π²ΠΎΠ²Π°Π½ΠΈΡ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ прогнозирования банкротства ΠΏΡƒΡ‚Π΅ΠΌ уточнСния Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½Ρ‹Ρ… Π·Π½Π°Ρ‡Π΅Π½ΠΈΠΉ ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ с ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ отраслСвой принадлСТности ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ ΠΈ для Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ авторской ΠΌΠΎΠ΄Π΅Π»ΠΈ прогнозирования банкротства. ΠŸΡ€Π΅ΠΆΠ΄Π΅ всСго, ΠΎΡ†Π΅Π½Π΅Π½Π° Ρ‚ΠΎΡ‡Π½ΠΎΡΡ‚ΡŒ ΠΏΡ€ΠΎΠ³Π½ΠΎΠ·Π° для ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ 8 отраслСй ΠΏΠΎ Π΄Π΅ΠΉΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΠΌ Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π°ΠΌ ΠΌΠΎΠ΄Π΅Π»Π΅ΠΉ прогнозирования банкротства. ΠŸΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΠΈ CART (Classification And Regression Tree) ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΎ ΡƒΡ‚ΠΎΡ‡Π½ΠΈΡ‚ΡŒ ΠΎΡ€ΠΈΠ³ΠΈΠ½Π°Π»ΡŒΠ½Ρ‹Π΅ Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Π½Ρ‹Π΅ значСния ΠΈ ΠΏΡ€Π΅Π΄Π»ΠΎΠΆΠΈΡ‚ΡŒ Π½ΠΎΠ²Ρ‹Π΅ ΠΈΠ½Π΄ΠΈΠ²ΠΈΠ΄ΡƒΠ°Π»ΡŒΠ½Ρ‹Π΅ Π³Ρ€Π°Π½ΠΈΡ†Ρ‹ ΠΎΡ†Π΅Π½ΠΊΠΈ для ΠΊΠ°ΠΆΠ΄ΠΎΠΉ отрасли. РассчитанныС значСния продСмонстрировали Π²Ρ‹ΡΠΎΠΊΡƒΡŽ ΠΏΡ€ΠΎΠ³Π½ΠΎΡΡ‚ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ ΡΠΏΠΎΡΠΎΠ±Π½ΠΎΡΡ‚ΡŒ ΠΈ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΠ»ΠΈ ΡΠ±Π°Π»Π°Π½ΡΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»ΠΈ точности прогнозирования для ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ-Π±Π°Π½ΠΊΡ€ΠΎΡ‚ΠΎΠ² ΠΈ финансово устойчивых ΠΎΡ€Π³Π°Π½ΠΈΠ·Π°Ρ†ΠΈΠΉ. Из ΠΎΠ±Ρ‰Π΅ΠΉ совокупности финансовых ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ, ΠΈΡΠΏΠΎΠ»ΡŒΠ·ΡƒΠ΅ΠΌΡ‹Ρ… Π² Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… модСлях, Π±Ρ‹Π»ΠΈ ΠΎΡ‚ΠΎΠ±Ρ€Π°Π½Ρ‹ коэффициСнты, ΠΎΠ±Π»Π°Π΄Π°ΡŽΡ‰ΠΈΠ΅ максимальной Π·Π½Π°Ρ‡ΠΈΠΌΠΎΡΡ‚ΡŒΡŽ для прогнозирования банкротства. На ΠΈΡ… основС Π±Ρ‹Π»Π° Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° новая модСль, Π΄Π΅ΠΌΠΎΠ½ΡΡ‚Ρ€ΠΈΡ€ΡƒΡŽΡ‰Π°Ρ Π²Ρ‹ΡΠΎΠΊΡƒΡŽ Ρ‚ΠΎΡ‡Π½ΠΎΡΡ‚ΡŒ Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² Π½Π° Π·Π°Π΄Π°Π½Π½ΠΎΠΉ Π²Ρ‹Π±ΠΎΡ€ΠΊΠ΅, ΠΈ Π½ΠΎΡ€ΠΌΠ°Ρ‚ΠΈΠ²Ρ‹ Π΅Π΅ ΠΎΡ†Π΅Π½ΠΊΠΈ для ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Ρ€Π°Π·Π»ΠΈΡ‡Π½Ρ‹Ρ… отраслСй. ΠŸΡ€Π°ΠΊΡ‚ΠΈΡ‡Π΅ΡΠΊΠΎΠ΅ ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ ΠΏΡ€Π΅Π΄Π»Π°Π³Π°Π΅ΠΌΡ‹Ρ… Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΎΠΊ ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ ΠΏΠΎΠ²Ρ‹ΡΠΈΡ‚ΡŒ ΡΡ„Ρ„Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ ΠΈ Π΄ΠΎΡΡ‚ΠΎΠ²Π΅Ρ€Π½ΠΎΡΡ‚ΡŒ прогнозирования банкротства, ΠΏΠΎΠ·Π²ΠΎΠ»ΠΈΡ‚ своСврСмСнно ΡΠΊΠΎΡ€Ρ€Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Ρ‚ΡŒ финансовоС состояниС ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ, ΠΊΠΎΡ‚ΠΎΡ€Ρ‹ΠΌ Π³Ρ€ΠΎΠ·ΠΈΡ‚ банкротство

    Condensation in Globally Coupled Populations of Chaotic Dynamical Systems

    Get PDF
    The condensation transition, leading to complete mutual synchronization in large populations of globally coupled chaotic Roessler oscillators, is investigated. Statistical properties of this transition and the cluster structure of partially condensed states are analyzed.Comment: 11 pages, 4 figures, revte

    НСфинансовыС Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹ формирования стоимости в систСмС финансового контроля стратСгии развития Ρ…ΠΎΠ»Π΄ΠΈΠ½Π³Π°

    Get PDF
    The growth of holding business structures predetermined the need to transform existing financial management tools. Among other results, a special financial control has appeared to achieve the long-term strategic company goals. Financial control of the development strategy with specific implementation is now one of the key management tools ensuring the prospective implementation of the company corporate strategy. The research objective is to determine the methodological basis for a controlled indicators system, considering non-financial factors of the company value formation. The methodological basis of the research consists of a systematic approach, use of statistical methods of data analysis and evaluation, content analysis. The results have been substanted due to the information published on the Moscow Exchange website, the Forbes rating of the largest Russian companies, the official websites of Russian companies. The research relevance is determined by need to clarify the content of financial control of holding development strategy and its implementation. The examples of building financial control systems in Russian companies have been provided. A universal scheme of financial control system has been created. Key methods of strategic financial control have been defined: strategic modelling; building value chains; factor and scenario analysis; in-depth study of financial status using mathematical and econometric methods and modern computer software. Regarding the specifics of financial control, its implementation scheme has been defined, and the main differences from the traditional implementation have been outlined. Company value maximizing is the main goal of financial control of the development strategy. It has substanted the control of non-financial cost factors. They include: company management model; the degree of social responsibility of the company; intellectual capital; the degree of innovation; customer loyalty and brand awareness; quality and novelty of products; company’s contribution to the socio-economic development of the country and regions where it is presented. Control of non-financial factors requires developing a system of controlled indicators. This is an advanced research direction of the topic.РаспространСниС бизнСс-структур, ΠΎΡ€Π³Π°Π½ΠΈΠ·ΠΎΠ²Π°Π½Π½Ρ‹Ρ… Π² Ρ„ΠΎΡ€ΠΌΠ΅ Ρ…ΠΎΠ»Π΄ΠΈΠ½Π³Π°, ΠΏΡ€Π΅Π΄ΠΎΠΏΡ€Π΅Π΄Π΅Π»ΠΈΠ»ΠΎ Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ трансформации ΡΡƒΡ‰Π΅ΡΡ‚Π²ΡƒΡŽΡ‰ΠΈΡ… инструмСнтов финансового управлСния. Одним ΠΈΠ· Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² ΠΏΠΎΠ΄ΠΎΠ±Π½Ρ‹Ρ… ΠΈΠ·ΠΌΠ΅Π½Π΅Π½ΠΈΠΉ стало появлСниС особого Π²ΠΈΠ΄Π° финансового контроля, ΠΎΡ€ΠΈΠ΅Π½Ρ‚ΠΈΡ€ΠΎΠ²Π°Π½Π½ΠΎΠ³ΠΎ Π½Π° достиТСниС долгосрочных стратСгичСских Ρ†Π΅Π»Π΅ΠΉ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ. Ѐинансовый ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΡŒ стратСгии развития, ΠΎΡ‚Π»ΠΈΡ‡Π°ΡŽΡ‰ΠΈΠΉΡΡ спСцифичСской Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠ΅ΠΉ Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ, Π² настоящий ΠΌΠΎΠΌΠ΅Π½Ρ‚ являСтся ΠΎΠ΄Π½ΠΈΠΌ ΠΈΠ· ΠΊΠ»ΡŽΡ‡Π΅Π²Ρ‹Ρ… управлСнчСских инструмСнтов, ΠΎΠ±Π΅ΡΠΏΠ΅Ρ‡ΠΈΠ²Π°ΡŽΡ‰ΠΈΡ… Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡ‚ΡŒ пСрспСктивной Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ ΠΊΠΎΡ€ΠΏΠΎΡ€Π°Ρ‚ΠΈΠ²Π½ΠΎΠΉ стратСгии ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ. ЦСль исслСдования β€”Β  ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ мСтодичСских основ формирования систСмы ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΠΈΡ€ΡƒΠ΅ΠΌΡ‹Ρ… ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ, ΡƒΡ‡ΠΈΡ‚Ρ‹Π²Π°ΡŽΡ‰Π΅ΠΉ нСфинансовыС Ρ„Π°ΠΊΡ‚ΠΎΡ€Ρ‹ формирования стоимости ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠ»ΠΎΠ³ΠΈΡ‡Π΅ΡΠΊΡƒΡŽ основу исслСдования составили систСмный ΠΏΠΎΠ΄Ρ…ΠΎΠ΄, ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ статистичСских ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² Π°Π½Π°Π»ΠΈΠ·Π° ΠΈ ΠΎΡ†Π΅Π½ΠΊΠΈ Π΄Π°Π½Π½Ρ‹Ρ…, ΠΊΠΎΠ½Ρ‚Π΅Π½Ρ‚-Π°Π½Π°Π»ΠΈΠ·. ОбоснованиС ΠΏΠΎΠ»ΡƒΡ‡Π΅Π½Π½Ρ‹Ρ… Ρ€Π΅Π·ΡƒΠ»ΡŒΡ‚Π°Ρ‚ΠΎΠ² достигнуто с использованиСм ΠΈΠ½Ρ„ΠΎΡ€ΠΌΠ°Ρ†ΠΈΠΈ, ΠΎΠΏΡƒΠ±Π»ΠΈΠΊΠΎΠ²Π°Π½Π½ΠΎΠΉ Π½Π° сайтС Московской Π±ΠΈΡ€ΠΆΠΈ, Ρ€Π΅ΠΉΡ‚ΠΈΠ½Π³Π° ΠΊΡ€ΡƒΠΏΠ½Π΅ΠΉΡˆΠΈΡ… российских ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ Forbes, ΠΎΡ„ΠΈΡ†ΠΈΠ°Π»ΡŒΠ½Ρ‹Ρ… сайтов российских ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΉ. ΠΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½ΠΎΡΡ‚ΡŒ исслСдования опрСдСляСт Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ уточнСния содСрТания финансового контроля стратСгии развития Ρ…ΠΎΠ»Π΄ΠΈΠ½Π³Π° ΠΈ Ρ‚Π΅Ρ…Π½ΠΎΠ»ΠΎΠ³ΠΈΠΈ Π΅Π³ΠΎ осущСствлСния. ΠŸΡ€ΠΈΠ²Π΅Π΄Π΅Π½Ρ‹ ΠΏΡ€ΠΈΠΌΠ΅Ρ€Ρ‹ построСния систСм финансового контроля Π² российских компаниях. БоставлСна ΡƒΠ½ΠΈΠ²Π΅Ρ€ΡΠ°Π»ΡŒΠ½Π°Ρ схСма систСмы финансового контроля. ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Ρ‹ ΠΊΠ»ΡŽΡ‡Π΅Π²Ρ‹Π΅ ΠΌΠ΅Ρ‚ΠΎΠ΄Ρ‹ стратСгичСского финансового контроля: стратСгичСскоС ΠΌΠΎΠ΄Π΅Π»ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅, построСниС Ρ†Π΅ΠΏΠΎΡ‡Π΅ΠΊ цСнностСй, Ρ„Π°ΠΊΡ‚ΠΎΡ€Π½Ρ‹ΠΉ ΠΈ сцСнарный Π°Π½Π°Π»ΠΈΠ·, ΡƒΠ³Π»ΡƒΠ±Π»Π΅Π½Π½ΠΎΠ΅ исслСдованиС финансового состояния с ΠΏΡ€ΠΈΠΌΠ΅Π½Π΅Π½ΠΈΠ΅ΠΌ матСматичСских ΠΈ экономСтричСских ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠ² ΠΈ соврСмСнного ΠΊΠΎΠΌΠΏΡŒΡŽΡ‚Π΅Ρ€Π½ΠΎΠ³ΠΎ обСспСчСния. Π‘ ΡƒΡ‡Π΅Ρ‚ΠΎΠΌ Π²Ρ‹Π΄Π΅Π»Π΅Π½Π½Ρ‹Ρ… особСнностСй финансового контроля стратСгии развития ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½Π° общая схСма Π΅Π³ΠΎ исполнСния, ΠΎΠ±ΠΎΠ·Π½Π°Ρ‡Π΅Π½Ρ‹ основныС отличия ΠΎΡ‚ Ρ€Π΅Π°Π»ΠΈΠ·Π°Ρ†ΠΈΠΈ финансового контроля Π² Ρ‚Ρ€Π°Π΄ΠΈΡ†ΠΈΠΎΠ½Π½ΠΎΠΌ ΠΏΠΎΠ½ΠΈΠΌΠ°Π½ΠΈΠΈ. ΠœΠ°ΠΊΡΠΈΠΌΠΈΠ·Π°Ρ†ΠΈΡ стоимости ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ ΠΊΠ°ΠΊ основная Ρ†Π΅Π»ΡŒ финансового контроля стратСгии развития обосновала Π½Π΅ΠΎΠ±Ρ…ΠΎΠ΄ΠΈΠΌΠΎΡΡ‚ΡŒ осущСствлСния контроля нСфинансовых Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ² стоимости. К Π½ΠΈΠΌ отнСсСны: модСль управлСния ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠ΅ΠΉ; ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠΉ отвСтствСнности ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ; ΠΈΠ½Ρ‚Π΅Π»Π»Π΅ΠΊΡ‚ΡƒΠ°Π»ΡŒΠ½Ρ‹ΠΉ ΠΊΠ°ΠΏΠΈΡ‚Π°Π»; ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ инновационности; Π»ΠΎΡΠ»ΡŒΠ½ΠΎΡΡ‚ΡŒ ΠΊΠ»ΠΈΠ΅Π½Ρ‚ΠΎΠ² ΠΈ ΡΡ‚Π΅ΠΏΠ΅Π½ΡŒ узнаваСмости Π±Ρ€Π΅Π½Π΄Π°; качСство ΠΈ Π½ΠΎΠ²ΠΈΠ·Π½Π° ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄ΠΈΠΌΠΎΠΉ ΠΏΡ€ΠΎΠ΄ΡƒΠΊΡ†ΠΈΠΈ; Π²ΠΊΠ»Π°Π΄ ΠΊΠΎΠΌΠΏΠ°Π½ΠΈΠΈ Π² ΡΠΎΡ†ΠΈΠ°Π»ΡŒΠ½ΠΎ-экономичСскоС Ρ€Π°Π·Π²ΠΈΡ‚ΠΈΠ΅ страны ΠΈ Ρ€Π΅Π³ΠΈΠΎΠ½ΠΎΠ² присутствия. ΠŸΡ€ΠΎΡ†Π΅ΡΡ контроля нСфинансовых Ρ„Π°ΠΊΡ‚ΠΎΡ€ΠΎΠ² Ρ‚Ρ€Π΅Π±ΡƒΠ΅Ρ‚ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚ΠΊΠΈ систСмы ΠΊΠΎΠ½Ρ‚Ρ€ΠΎΠ»ΠΈΡ€ΡƒΠ΅ΠΌΡ‹Ρ… ΠΏΠΎΠΊΠ°Π·Π°Ρ‚Π΅Π»Π΅ΠΉ. Π­Ρ‚ΠΎ являСтся пСрспСктивным Π½Π°ΠΏΡ€Π°Π²Π»Π΅Π½ΠΈΠ΅ΠΌ исслСдования рассматриваСмой Ρ‚Π΅ΠΌΡ‹

    ΠžΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ противосудороТного срСдства Π“Π˜Π–-290 Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ крыс ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ высокоэффСктивной Тидкостной Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ с масс-спСктромСтричСским Π΄Π΅Ρ‚Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ

    Get PDF
    GIZh-290 is a new derivative of 4-phenylpyrrolidone, based on the structures of racetams that combine anticonvulsant and nootropic effects. The method of high-performance liquid chromatography with mass spectrometric detection was developed and validated for the quantitative determination of a new potential anticonvulsant compound GIZh-290 in rat blood plasma. For the extraction of the analyte, liquid-liquid extraction with diethyl ether was used. The method was validated based on its selectivity, linearity, accuracy, precision, and stability. The linearity of the method was confirmed by a high correlation coefficient of 0.999. The percent recovery of GIZh-290 from blood plasma was 79.2 %. The intra- and inter-batch accuracy were 19.32 and 12.14 %. Β It was found that blood plasma samples containing GIZh-290 can be stored at ambient temperature during the working day.Π“Π˜Π–-290 – Π½ΠΎΠ²ΠΎΠ΅ ΠΏΡ€ΠΎΠΈΠ·Π²ΠΎΠ΄Π½ΠΎΠ΅ 4-Ρ„Π΅Π½ΠΈΠ»ΠΏΠΈΡ€Ρ€ΠΎΠ»ΠΈΠ΄ΠΎΠ½Π°, синтСзированноС Π½Π° основС Ρ€Π°Ρ†Π΅Ρ‚Π°ΠΌΠΎΠ², ΡΠΎΡ‡Π΅Ρ‚Π°ΡŽΡ‰ΠΈΡ… противосудороТноС ΠΈ Π½ΠΎΠΎΡ‚Ρ€ΠΎΠΏΠ½ΠΎΠ΅ дСйствиС. Π“Π˜Π–-290 ΠΎΠ±Π»Π°Π΄Π°Π΅Ρ‚ ΡˆΠΈΡ€ΠΎΠΊΠΈΠΌ спСктром противосудороТных ΠΈ Π½ΠΎΠΎΡ‚Ρ€ΠΎΠΏΠ½Ρ‹Ρ… эффСктов. ΠœΠ΅Ρ‚ΠΎΠ΄ΠΎΠΌ высокоэффСктивной Тидкостной Ρ…Ρ€ΠΎΠΌΠ°Ρ‚ΠΎΠ³Ρ€Π°Ρ„ΠΈΠΈ с масс-спСктромСтричСским Π΄Π΅Ρ‚Π΅ΠΊΡ‚ΠΈΡ€ΠΎΠ²Π°Π½ΠΈΠ΅ΠΌ Ρ€Π°Π·Ρ€Π°Π±ΠΎΡ‚Π°Π½Π° ΠΈ Π²Π°Π»ΠΈΠ΄ΠΈΡ€ΠΎΠ²Π°Π½Π° ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠ° количСствСнного опрСдСлСния Π½ΠΎΠ²ΠΎΠ³ΠΎ ΠΏΠΎΡ‚Π΅Π½Ρ†ΠΈΠ°Π»ΡŒΠ½ΠΎΠ³ΠΎ противосудороТного срСдства соСдинСния Π“Π˜Π–-290 Π² ΠΏΠ»Π°Π·ΠΌΠ΅ ΠΊΡ€ΠΎΠ²ΠΈ крыс. Для извлСчСния Π°Π½Π°Π»ΠΈΡ‚Π° использовали ΠΆΠΈΠ΄ΠΊΠΎΡΡ‚ΡŒ-ΠΆΠΈΠ΄ΠΊΠΎΡΡ‚Π½ΡƒΡŽ ΡΠΊΡΡ‚Ρ€Π°ΠΊΡ†ΠΈΡŽ диэтиловым эфиром. Π’Π°Π»ΠΈΠ΄Π°Ρ†ΠΈΡŽ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ ΠΏΡ€ΠΎΠ²ΠΎΠ΄ΠΈΠ»ΠΈ ΠΎΠΏΡ€Π΅Π΄Π΅Π»Π΅Π½ΠΈΠ΅ΠΌ Ρ‚Π°ΠΊΠΈΡ… Π΅Ρ‘ ΠΏΠ°Ρ€Π°ΠΌΠ΅Ρ‚Ρ€ΠΎΠ², ΠΊΠ°ΠΊ ΡΠ΅Π»Π΅ΠΊΡ‚ΠΈΠ²Π½ΠΎΡΡ‚ΡŒ, Π»ΠΈΠ½Π΅ΠΉΠ½ΠΎΡΡ‚ΡŒ, ΠΏΡ€Π°Π²ΠΈΠ»ΡŒΠ½ΠΎΡΡ‚ΡŒ, ΠΏΡ€Π΅Ρ†ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΡΡ‚ΡŒ ΠΈ ΡΡ‚Π°Π±ΠΈΠ»ΡŒΠ½ΠΎΡΡ‚ΡŒ. Π›ΠΈΠ½Π΅ΠΉΠ½ΠΎΡΡ‚ΡŒ ΠΌΠ΅Ρ‚ΠΎΠ΄ΠΈΠΊΠΈ ΠΏΠΎΠ΄Ρ‚Π²Π΅Ρ€ΠΆΠ΄Π΅Π½Π° высоким коэффициСнтом коррСляции Ρ€Π°Π²Π½Ρ‹ΠΌ 0,999. ΠŸΡ€ΠΎΡ†Π΅Π½Ρ‚ извлСчСния Π“Π˜Π–-290 ΠΈΠ· ΠΏΠ»Π°Π·ΠΌΡ‹ ΠΊΡ€ΠΎΠ²ΠΈ Π² срСднСм составил 79,2 %. ΠŸΡ€Π°Π²ΠΈΠ»ΡŒΠ½ΠΎΡΡ‚ΡŒ Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ Ρ€Π°Π±ΠΎΡ‡Π΅Π³ΠΎ Ρ†ΠΈΠΊΠ»Π° ΠΈ ΠΌΠ΅ΠΆΠ΄Ρƒ Ρ†ΠΈΠΊΠ»Π°ΠΌΠΈ Π±Ρ‹Π»Π° ≀19,32 %, ΠΏΡ€Π΅Ρ†ΠΈΠ·ΠΈΠΎΠ½Π½ΠΎΡΡ‚ΡŒ ≀12,14 %. УстановлСно, Ρ‡Ρ‚ΠΎ ΠΎΠ±Ρ€Π°Π·Ρ†Ρ‹ ΠΏΠ»Π°Π·ΠΌΡ‹ ΠΊΡ€ΠΎΠ²ΠΈ, содСрТащиС Π“Π˜Π–-290, ΠΌΠΎΠΆΠ½ΠΎ Ρ…Ρ€Π°Π½ΠΈΡ‚ΡŒ ΠΏΡ€ΠΈ ΠΊΠΎΠΌΠ½Π°Ρ‚Π½ΠΎΠΉ Ρ‚Π΅ΠΌΠΏΠ΅Ρ€Π°Ρ‚ΡƒΡ€Π΅ Π² Ρ‚Π΅Ρ‡Π΅Π½ΠΈΠ΅ Ρ€Π°Π±ΠΎΡ‡Π΅Π³ΠΎ дня

    Delay-induced chaos in catalytic surface reactions

    No full text
    Deterministic chaos related to a sequence of period-doubling bifurcations (the Feigenbaumtransition) has been observed in the NO1+CO and NO+H2 reactions on Pt(100). On a microscopicscale, these reactions are accompanied by the formation of 1X1 adsorbate islands due to theproperties of the 1X1↔hex phase transition of Pt(100). A simple skeleton model is constructed thatdescribes the behavior of a population of reacting islands which are globally coupled together viathe gas phase. Investigations of this model show that the experimentally observed chaotic behaviorcan result from delays in the response of the reacting islands to partial pressure variations in the gasphase

    Modern Understanding of Internal Financial Control: Problems and Perspectives of Investigation

    Get PDF
    The analytical review of national and foreign approaches to the internal financial control is presented in this paper. The examination of existing approaches enabled to define the internal financial control as one of the management spheres within the economic entity, which provides the efficient achievement of goals and is realized by constructing a system of interrelated elements. Nevertheless the key moments of the notion specification are its aims and objectives, which vary depending on the nature of business, its scale and the levels of internal financial control realization. The authors’ understanding of demarcation of different financial control designations was noted as one of the conclusions. For instance, it seems necessary to divide such determinations as internal and corporate control as far as the corporate control category covers only some of the objects of internal financial control that limits the scope of its use. The article also touches upon the demarcation between the concepts of financial control, controlling, and internal audit. The authors determine the internal financial control as one of the key areas of practical implementation of controlling tasks and objectives. According to the hierarchy of concepts presented in the article, internal audit serves as the main tool of internal financial control. The emerging role of system and value-based approach, the necessity of industry and structure characteristics consideration during the process of internal financial control system development, the introduction of a new perspective direction of strategy financial control are pointed out as the main tendencies of internal financial control investigation. The undertaken analysis of existing approaches allowed forming a strong theoretical basis for the examination of practical aspects of internal financial control development and determining the key directions of the investigation

    Tonality of Showing Russian Position in English Speaking Mass Media during Sanction Period

    No full text
    Highly charged political environment, which is peculiar to the current stage of international relationsΒ  development, is accompanied by an extensive media war. The problem of showing Russia onΒ the negative side in international press wasΒ known and discussed since early 2000-s. Russian-Ukrainian conflict which started atΒ  the end of 2013 – beginning of 2014 provokedΒ foreign mass media to make a point of Russia and enhance the quantity of adverse statements towards the country. It seems that theΒ aim of foreign mass media is to form an antagonistic image of Russia among the audience. The research under discussion is devoted to the problem ofΒ  the sentiment of showingΒ Russia in English speaking mass media underΒ the influence of Russia sanctions. News textsΒ for period from 2012 till 2018 were analyzed. The whole period was divided into several stages: the firstΒ  stage is connected with period before sanctions; the others reflect different phases of restrictions’ imposition.Β  The authors suggested that foreign mass media is inclined to show Russia on the negative side irrespective ofΒ  the contents of political situationΒ during the sanctions period. To approve thisΒ statement a detailed text analysis was provided to find out the following indicators: the total quantity of news, connected with Russia,Β in the stated period; the quantity of positiveΒ and negative words. It was found out that theΒ sanctions imposition provoked the increaseΒ of total Russia media hits, but the increase ofΒ negative words was higher than the increaseΒ of positive words. Reviewing the contest ofΒ news from the perspective of correlation between the words showed that Russia-Ukrainian conflictΒ  theme lost its significance, but theΒ total level of enmity in news text remainedΒ the same and even has the tendency of increasing in line with the other political events
    corecore