Biological Markers of Fitness Among Qualified Athletes in Greco-Roman Wrestling

The article presents the dynamics of the fitness indicators among qualified athletes in Greco-Roman wrestling in the process of their pre-competition training as a reflection of adaptive changes during performed exercises The changing dynamics of the studied indicators and their variability during pre-competition training is a phenomenon of functional reactions of the body s internal systems Adaptive changes in the energy systems of qualified athletes in the process of training highlight the specifics of training work in Greco-Roman wrestling It is crucial to control these changes during a series of shock training loads of each weekly microcycl

Structuring Framework for Early Validation of Product Ideas

The advancing digitalization leads to new challenges in the development of new product ideas. The systems, which need to be developed, are becoming increasingly complex. As complexity rises, so does the slowness of organizations. In order to remain innovative and be able to react quickly to changes in the market, validation approaches offer great potential. An essential focus is the early, customer-centric and continuous validation of development artefacts. This is the only way to cope with shorter development cycles, and develop products that address a real need. To plan a validation, engineers need to have an idea about the possibilities within a validation. This paper presents a structuring framework for early validation of product ideas, which contains the three tools of Validation Map, Building Block Cards and Validation Canvas. The objective is to enable easier planning of validation experiments

Thrust Vector Control within a Geometric Sphere, and the Use of Euler's Tips to Create Jet Technology

This study aims to study the issues of choosing promising directions for the development of jet technology with the creation of energy-conserving technologies. The purpose of this article is to study the issues of choosing promising directions for the development of jet technology with the creation of energy-saving. Methodological approaches have been developed for solving inventive problems within the framework of training modern designers-inventors. A new patentable jet unit has been developed and presented, which makes it possible to control the thrust vector within a complete geometric sphere (when the thrust vector is capable of deviating to any angle ranging from +180° to -180°). For the first time, demonstration versions of a nozzle apparatus capable of realizing such flow reversals through annular channels are shown. The results of computer modeling of nozzle devices are focused on energy, production, and processing of hydrocarbons when distributing energy flows at process facilities. The individual results of the ongoing work can also be used in other industries, for instance, in the creation of small-sized high-speed unmanned vehicles for search and rescue operations. Proposals have been prepared to improve the methodology for solving inventive problems as part of the development of Leonard Euler’s ideas. Doi: 10.28991/CEJ-2023-09-10-011 Full Text: PD

Designing Mesh Turbomachinery with the Development of Euler’s Ideas and Investigating Flow Distribution Characteristics

This research discusses developing an Euler turbine-based hybrid mesh turbomachinery. Within the framework of mechanical engineering science, turbomachinery classification and a novel method for mesh turbomachinery design were considered. In such a turbomachine, large blades are replaced by a set of smaller blades, which are interconnected to form flow channels in a mesh structure. Previous studies (and reasoning within the framework of inductive and deductive logic) showed that the jet mesh control system allows for operation with several flows simultaneously and provides a pulsed flow regime in flow channels. This provides new opportunities for expanding the control range and reducing the thermal load on the turbomachine blades. The novel method for performance evaluation was confirmed by the calculation: the possibility of implementing pulsed cooling of blades periodically washed by a hot working gas flow (at a temperature of 1000°C) and a cold gas flow (at a temperature of 20°C) was shown. The temperature of the blade walls remained 490–525°C. New results of ongoing research are focused on creating multi-mode turbomachinery that operates in complicated conditions, e.g., in offshore gas fields. Gas energy is lost and dissipated in the throttle at the mouth of each high-pressure well. Within the framework of ongoing research, the environmentally friendly net reservoir energy of high-pressure well gas should be rationally used for operating a booster compressor station. Here, the energy consumption from an external power source can be reduced by 50%, according to preliminary estimates. Doi: 10.28991/CEJ-2022-08-11-017 Full Text: PD

Interdisciplinary Studies of Jet Systems using Euler Methodology and Computational Fluid Dynamics Technologies

This study aims to conduct interdisciplinary research using computerized solutions to inventive problems in fluidics. The chosen direction of work relates to the scientific search for new opportunities for extremal control of the thrust vector within a complete geometric sphere (with the range of rotation angle change for the thrust vector being ±180° in any direction). This study assesses the prospects for the emergence of patentable innovative solutions for maneuverable unmanned vehicles. One of the most urgent tasks is to increase the process efficiency in forming fluid medium flow, expanding opportunities for controlling this flow parameter. The research uses an interdisciplinary approach with simulation modeling. The authors of the paper reveal new possibilities for using an ejector with two curved mixing chambers to create special jet units. Calculations (CFD) have confirmed the performance of the simulator ejector when controlling the thrust vector with 90° and 180° rotation. Manufacturing physical micromodels used additive technologies to allow simulation modeling under laboratory conditions. Using “data mining” methods, it was shown for the first time that, based on Euler’s ideas and methodology, it is possible to create a new methodology for teaching and solving inventive problems. The research results apply to power engineering and unmanned vehicles. Some results of scientific studies can be used to create special computer programs working together with artificial intelligence to create advanced techniques and technologies. Doi: 10.28991/HIJ-2023-04-04-01 Full Text: PD

Development and Prototyping of Jet Systems for Advanced Turbomachinery with Mesh Rotor

This article presents the research results that aim to develop promising mesh turbomachines equipped with jet control systems. The turbomachines operating in difficult conditions in oil and gas production are mainly considered. At the same time, some research results can be used in other production branches, including power engineering and transport. Three-dimensional models for computer simulation of net turbines and jet control systems were developed. Prototypes and micromodels were created to test the performance of mesh turbines and jet control systems using additive technologies. A methodological approach is proposed to create a classification of jet control systems considering their design and technological features. In the course of numerical experiments, the extreme conditions of fluid and gas outflow through a nozzle equipped with a velocity vector control system, in the control range of adjustment of the velocity vector deflection angle from + 90o to -90o within a geometric hemisphere, have been considered for the first time. It was also shown that when using a dual-channel nozzle, there are possibilities to adjust the velocity vector angle (thrust vector) in the range of + 180o to -180owithin the geometric sphere. Compared with the known variants, the control range of the velocity vector angle is increased by nine times. These calculated data are presented in addition to the previously published results of physical laboratory experiments. Preliminary results of numerical experiments show the possibility of creating a new theory in the field of mesh turbines and jet systems. Patents support the novelty of the developed technical solutions. Doi: 10.28991/esj-2021-01311 Full Text: PD

Computational Fluid Dynamics (CFD) Simulation of Mesh Jet Devices for Promising Energy-Saving Technologies

This paper discusses the development of mesh jet devices for hybrid turbines, including developing Euler's ideas, and considers a new patented version of a mesh jet device designed to create guiding devices for turbines. The research methods are based on simulations using CFD and additive technologies. An intermediate conclusion is that a new scientific direction for the study and creation of mesh jet control systems has been formed as part of developing Euler's ideas. Calculation methods showed possible improvements in the performance of jet devices, including the use of curved tubes proposed by Euler to create turbines. This study shows that at the nozzle or mixing chamber outlet, the jet can deflect by an angle from +180° to -180° within the geometric sphere. This study also shows that the scientific groundwork prepared by Euler is not yet fully understood. The ongoing research mainly focuses on creating multi-mode jet devices designed for control systems for mesh turbomachines. Here, power consumption from an external source can be reduced to save energy. Some results of ongoing studies can also be applied in other industries (for example, when creating hybrid propulsion systems or propulsors). The scientific novelty of this work consists of improving the design methodology of jet machinery and turbomachines. Doi: 10.28991/CEJ-2022-08-12-06 Full Text: PD

Genome-wide detection of human intronic AG-gain variants located between splicing branchpoints and canonical splice acceptor sites

Human genetic variants that introduce an AG into the intronic region between the branchpoint (BP) and the canonical splice acceptor site (ACC) of protein-coding genes can disrupt pre-mRNA splicing. Using our genome-wide BP database, we delineated the BP-ACC segments of all human introns and found extreme depletion of AG/YAG in the [BP+8, ACC-4] high-risk region. We developed AGAIN as a genome-wide computational approach to systematically and precisely pinpoint intronic AG-gain variants within the BP-ACC regions. AGAIN identified 350 AG-gain variants from the Human Gene Mutation Database, all of which alter splicing and cause disease. Among them, 74% created new acceptor sites, whereas 31% resulted in complete exon skipping. AGAIN also predicts the protein-level products resulting from these two consequences. We performed AGAIN on our exome/genomes database of patients with severe infectious diseases but without known genetic etiology and identified a private homozygous intronic AG-gain variant in the antimycobacterial gene SPPL2A in a patient with mycobacterial disease. AGAIN also predicts a retention of six intronic nucleotides that encode an in-frame stop codon, turning AG-gain into stop-gain. This allele was then confirmed experimentally to lead to loss of function by disrupting splicing. We further showed that AG-gain variants inside the high-risk region led to misspliced products, while those outside the region did not, by two case studies in genes STAT1 and IRF7. We finally evaluated AGAIN on our 14 paired exome-RNAseq samples and found that 82% of AG-gain variants in high-risk regions showed evidence of missplicing

The solubility of calcium sulphide in calcium metasilicate

42 leaves : ill. ; 29 cm