1 research outputs found
Impact of Pore–Walls Ligand Assembly on the Biodegradation of Mesoporous Organosilica Nanoparticles for Controlled Drug Delivery
Porous materials with molecular-scale
ordering have attracted major
attention mainly because of the possibility to engineer their pores
for selective applications. Periodic mesoporous organosilica is a
class of hybrid materials where self-assembly of the organic linkers
provides a crystal-like pore wall. However, unlike metal coordination,
specific geometries cannot be predicted because of the competitive
and dynamic nature of noncovalent interactions. Herein, we study the
influence of competing noncovalent interactions in the pore walls
on the biodegradation of organosilica frameworks for drug delivery
application. These results support the importance of studying self-assembly
patterns in hybrid frameworks to better engineer the next generation
of dynamic or “soft” porous materials