2 research outputs found
Active-passive Immunization Effectiveness Against Hepatitis B Virus in Children Born to HBsAg Positive Mothers in Amol, North of Iran
Objectives: HBV infection is a contagious disease that may
transmit vertically from mothers to their neonates or horizontally
by blood products and body secretions. Over 50% of Iranian
carriers have contracted the infection perinatally, making this
the most likely route of transmission of HBV in Iran. Tis study
assesses the serologic markers of HBV in children born to HBsAg
positive mothers who received HBIG and 3 doses of HBV vaccine.
Methods: To evaluate the effectiveness of vaccination against
HBV, a study was conducted on 95 Children, born to hepatitis
B surface antigen (HBsAg)-positive mothers, who had received
Hepatitis B Immune Globulin and HBV vaccines during 2004-
2008. All children were tested for the presence of HBsAg, antiHBs and anti-HB core antigen (anti-HBc).
Results: Among an estimated 30000 pregnant women during the
fve year study, about 130 (0.42%) were HBV carriers. Ninety-fve
children from these mothers were enrolled in this study. Only one
child (1.1%) was HBsAg positive, while 88.4% of children were
Anti-HBs Positive. Eleven children (11.6%) were exposed to HBV
as shown by the presence of anti-HBc. A signifcant difference was
observed between the children’s age and Anti-HBs (p=0.0001).
Conclusion: Passive-active immunoprophylaxis of high risk babies
was highly efcacious in preventing perinatal transmission of the
HBV carrier state. Also, evaluation of serologic markers in HBV
infected people is important for designing the strategies for disease
control