Human Oral Mucosa Tissue-Engineered Constructs Monitored by Raman Fiber-Optic Probe

In maxillofacial and oral surgery, there is a need for the development of tissue-engineered constructs. They are used for reconstructions due to trauma, dental implants, congenital defects, or oral cancer. A noninvasive monitoring of the fabrication of tissue-engineered constructs at the production and implantation stages done in real time is extremely important for predicting the success of tissue-engineered grafts. We demonstrated a Raman spectroscopic probe system, its design and application, for real-time ex vivo produced oral mucosa equivalent (EVPOME) constructs noninvasive monitoring. We performed in vivo studies to find Raman spectroscopic indicators for postimplanted EVPOME failure and determined that Raman spectra of EVPOMEs preexposed to thermal stress during manufacturing procedures displayed correlation of the band height ratio of CH2 deformation to phenylalanine ring breathing modes, giving a Raman metric to distinguish between healthy and compromised postimplanted constructs. This study is the step toward our ultimate goal to develop a stand-alone system, to be used in a clinical setting, where the data collection and analysis are conducted on the basis of these spectroscopic indicators with minimal user intervention.Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/140248/1/ten.tec.2013.0622.pd

Goodness of fit tests for "Chimeric" alternatives

this paper we discuss nonparametric goodness of fit theory for alternatives, which, in practical terms, manifest themselves not as a "smooth" and "small" deviation "everywhere", but as still not big systematic "stains" or highly oscillating patterns as compared to the regular null hypothesis. Key Words & Phrases: contiguous alternatives, compactness, weakly converging linear functionals, spike alternatives, divisible statistics, Brownian motion, convergence in distribution in L1 , uniform Donsker classes. 1 Introductio

The Two-Sample Problem In R^m And Measure-Valued Martingales

... this paper we present an approach based on measure-valued martingales and we will show that the stochastic process obtained with this approach is a solution to the two-sample problem, i.e. it has both the properties (ff) and (fi), for any m 2 IN

Magnetic field dependence of the copper charge density wave order in a YBa2Cu3O7 Nd0.65 Ca0.7Sr0.3 0.35MnO3 superlattice

For a YBa2Cu3O7 Nd0.65 Ca0.7Sr0.3 0.35MnO3 YBCO NCSMO superlattice, we studied with resonant elastic x ray scattering REXS at the Cu L3 edge how the copper sublattice charge density wave Cu CDW order in YBCO is affected by a large magnetic field up to 6.9 T that weakens the CE type antiferromagnetic AF and the charge orbital Mn CO orders of the manganite in favor of a ferromagnetic state. While a field of only 2 T induces a strong ferromagnetic moment in the manganite, we find that the Bragg peak of the Cu CDW hardly changes up to 6 T. Moreover, as the magnetic field is further increased to 6.9 T, the Cu CDW Bragg peak gets suddenly enhanced and broadened, whereas the ferromagnetic moment of the manganite is already saturated. The observed uncorrelated magnetic field dependence of the charge orders in the cuprate and manganite layers suggests that these orders are not directly coupled across the interface. We rather interpret our data in terms of an indirect coupling via the domain boundaries of the Mn CO and the related disorder and lattice strain. This interpretation is supported by additional studies of the magnetoelectric response, which provide evidence for a crossover in the dynamics of the Mn CO in the range between 6 and 7 T, from a low field state with pinned domains to a high field state with more mobile and flexible domain boundaries. We attribute the concomitant enhancement and broadening of the Cu CDW Bragg peak to this crossove