Perceptions of Pediatricians on the SARs-CoV2 Vaccine

Introduction: The novel SARs-CoV2 coronavirus has infected approximately 30,000,000 people in the USA. To date, approximately 146 million doses of SARs-CoV2 vaccines have been administered. Perceptions of rapid vaccine development have resulted in reported vaccine hesitancy and refusal. Though not currently FDA approved for use in pediatric populations, but pediatric vaccination may contribute to herd immunity. Previous study demonstrates that physician recommendations significantly impact perceptions of routine pediatric immunizations among parents. Given this historical data, this study aimed to describe the strength of recommendation by pediatricians for the SARs-CoV2 vaccine for pediatric patients and their parents. Methods: A 10-question single-institution anonymous survey was distributed to physicians in the Department of Pediatrics, consisting of 2 demographic questions, 5 Likert-style survey questions on vaccine recommendations, and 2 free-responses for comments on current vaccine development for thematic analysis. Results: There were 90 survey responses, and no responses were excluded from analysis. The most common sources of vaccine information among pediatricians were peer-reviewed journals (51%) and major broadcast or print materials (30%). A majority of pediatricians indicated that they read about vaccine information either weekly (44%) or monthly (27%). Of the survey respondents, 99% indicated that they had personally received a SARs-CoV2 vaccine. For pediatric vaccine recommendations, 69% responded that they strongly encouraged their pediatric patients to receive a SARs-CoV2 vaccine, compared to 87% recommending SARs-CoV2 vaccine for parents and 96% recommending the annual influenza vaccine. Thematic analysis of free response questions demonstrated that physicians cited the need for herd immunity (42%) and the protection of their patients (41%) as reasons for recommending the vaccine, and cited lack of research or FDA approval of vaccine use in pediatric populations (61%) as reasons for recommending against receiving the vaccine. Conclusions: This single-center survey study demonstrated that a majority of pediatricians strongly encourage their pediatric patients to receive a SARs-CoV2 vaccine, though not as strongly as they recommend vaccination to their patients’ parents or vaccination against influenza. Thematic analysis indicated that physicians cite the need for population-level herd immunity as well as individual-level protection from SARs-CoV2 infection as a basis for their vaccine recommendations.https://digitalcommons.unmc.edu/chri_forum/1013/thumbnail.jp

Intraventricular Septation in the Context of Dilated Cardiomyopathy Associated With TTN Mutation

A 6-month-old infant boy presented with symptomatic heart failure. Dilated cardiomyopathy was found in association with a mutation in TTN. Structural heart disease included novel septation of the left ventricle with a fenestrated membrane resulting from aberrant congenital mitral valve apparatus formation. (Level of Difficulty: Advanced.)

Electrospun nanofiber scaffolds with gradations in fiber organization

The goal of this protocol is to report a simple method for generating nanofiber scaffolds with gradations in fiber organization and test their possible applications in controlling cell morphology/orientation. Nanofiber organization is controlled with a new fabrication apparatus that enables the gradual decrease of fiber organization in a scaffold. Changing the alignment of fibers is achieved through decreasing deposition time of random electrospun fibers on a uniaxially aligned fiber mat. By covering the collector with a moving barrier/mask, along the same axis as fiber deposition, the organizational structure is easily controlled. For tissue engineering purposes, adipose-derived stem cells can be seeded to these scaffolds. Stem cells undergo morphological changes as a result of their position on the varied organizational structure, and can potentially differentiate into different cell types depending on their locations. Additionally, the graded organization of fibers enhances the biomimicry of nanofiber scaffolds so they more closely resemble the natural orientations of collagen nanofibers at tendon-to-bone insertion site compared to traditional scaffolds. Through nanoencapsulation, the gradated fibers also afford the possibility to construct chemical gradients in fiber scaffolds, and thereby further strengthen their potential applications in fast screening of cell-materials interaction and interfacial tissue regeneration. This technique enables the production of continuous gradient scaffolds, but it also can potentially produce fibers in discrete steps by controlling the movement of the moving barrier/mask in a discrete fashion

Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization

The goal of this protocol is to report a simple method for generating nanofiber scaffolds with gradations in fiber organization and test their possible applications in controlling cell morphology/orientation. Nanofiber organization is controlled with a new fabrication apparatus that enables the gradual decrease of fiber organization in a scaffold. Changing the alignment of fibers is achieved through decreasing deposition time of random electrospun fibers on a uniaxially aligned fiber mat. By covering the collector with a moving barrier/mask, along the same axis as fiber deposition, the organizational structure is easily controlled. For tissue engineering purposes, adipose-derived stem cells can be seeded to these scaffolds. Stem cells undergo morphological changes as a result of their position on the varied organizational structure, and can potentially differentiate into different cell types depending on their locations. Additionally, the graded organization of fibers enhances the biomimicry of nanofiber scaffolds so they more closely resemble the natural orientations of collagen nanofibers at tendon-to-bone insertion site compared to traditional scaffolds. Through nanoencapsulation, the gradated fibers also afford the possibility to construct chemical gradients in fiber scaffolds, and thereby further strengthen their potential applications in fast screening of cell-materials interaction and interfacial tissue regeneration. This technique enables the production of continuous gradient scaffolds, but it also can potentially produce fibers in discrete steps by controlling the movement of the moving barrier/mask in a discrete fashion

How to do multilingual literary history? Lessons from fifteenth- and sixteenth-century north India

How can we conceptualise multingual literary culture and how can we research it? Drawing upon a 3-year AHRC funded project, this essay focuses on the materiality of the marchive, on the spaces and locations in which literature was produced and performed, and on the oral-performative practices and agents that made texts circulate to audiences in ways not bound by the script in which the texts appear to us.Not only are the models of composite culture and language specificity questioned as aresult, but the sites of literary production move from the court to a series of intersections, and areas that were peripheral move into view and connect with others