13 research outputs found
Visualization of adenosine A1 receptors in rat brain, using 11C-MPDX and microPET: effect of raised levels of extracellular adenosine
No full textImaging adipose tissue browning using the TSPO-18kDa tracer [18F]FEPPA
No full text10.1016/j.molmet.2019.05.003Molecular Metabolism25154-15
Adenosine A(2A) Receptor Antagonists as Positron Emission Tomography (PET) Tracers
No full textThe adenosine A(2A) receptor (A(2A)R) is highly concentrated in the striatum, and a therapeutic target for Parkinson's disorder (PD) and Huntington's disease. High affinity and selective radiolabeled A(2A)R antagonists can be important research and diagnostic tools for PD. Positron Emission Tomography (PET) can play an important role by measuring radiolabeled A(2A) antagonists non-invasively in the brain. However, till date no complete review on A(2A)R PET ligands is available. The present article has been therefore focused on available PET tracers for A(2A)R and their detailed biological evaluation in rodents, nonhuman primates and humans. Drug design and development by molecular modeling including new lead structures that are potential candidates for radiolabeling and mapping of cerebral A(2A)Rs is discussed in the present article. A brief overview of functions of adenosine in health and disease, including the relevance of A(2A)R for PD has also been presented
Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson's disease
No full text10.1186/s13287-020-01868-4Stem Cell Research and Therapy11134
Radiation Dosimetry of a Novel Adenosine A2A Receptor Radioligand [11C]Preladenant Based on PET/CT Imaging and Ex Vivo Biodistribution in Rats
No full textMolecular modeling of potential PET imaging agents for adenosine receptor in Parkinson’s disease
No full textHypoglycemic and hypolipidemic activities of aqueous extract of flowers from Nycantus arbor-tristis L. in male mice
No full text
