Scleral buckling surgery for rhegmatogenous retinal detachment with subretinal proliferation

PurposeTo evaluate the outcome of scleral buckling surgery in patients with rhegmatogenous retinal detachment (RRD) with subretinal proliferation.MethodsIn this retrospective study, a chart review of all patients with RRD associated with subretinal proliferation who were primarily treated with scleral buckling procedure, from April 2007 to April 2014, was undertaken. Main outcome measures were anatomical retinal reattachment and visual acuity.ResultsForty-four eyes of 43 patients including 24 males and 19 females with a mean age of 26.5±13.1 years were evaluated. Immediately after the surgery, retina was reattached in all eyes. However, five eyes (11.3) needed additional surgery for retinal redetachment. Single surgery anatomical success rate was 88.7. Four eyes (9.1), needed pars plana vitrectomy for the treatment of redetachment associated with proliferative vitreoretinopathy and scleral buckle revision surgery was successfully performed in the other eye. Best corrected visual acuity improved from 1.5±0.9 logMAR before surgery to 1.1±0.7 logMAR after surgery (P2 lines was found in 23 eyes (52.2) and worsening of best corrected visual acuity of >2 lines was observed in 2 eyes (4.5).ConclusionsScleral buckling surgery is highly successful in eyes with RRD associated with subretinal proliferation. © 2015 Macmillan Publishers Limited All rights reserved

Determination of the toxicity of intravitreal minocycline in rabbit eyes

Purpose: To evaluate the retinal toxicity of intravitreal minocycline in rabbit eyes. Methods: Intravitreal injection of minocycline with concentrations of 1000, 500, 250, 125 and 62.5 μg in 0.1 ml was performed in 10 New Zealand albino rabbits. Each concentration was injected into two rabbit eyes. For each dose, normal saline was injected in one contralateral eye and the other fellow eye remained non-injected. Electrophysiologic testing was performed before and 4 weeks after injections. The eyes were enucleated 4 weeks after injections and examined using light microscopy. Results: The clinical examination was unremarkable after injections. Electroretinography recordings were significantly affected at all doses in at least one of the a- or b-waves of photopic or scotopic responses. Histopathologic examination revealed marked atrophy and loss of integrity in all retinal layers in all minocycline injected eyes. Contralateral eyes were normal. Conclusion: In our study, intravitreal minocycline was toxic to the retina in albino rabbits even at a concentration of 62.5 µg/0.1 ml. © 2015 Taylor & Francis