A clinical study of arrhythmias associated with acute coronary syndrome: a hospital based study of a high risk and previously undocumented population

Background: ACS represents a global epidemic. Arrhythmia in ACS is common. Careful investigation may lead to further improvement of prognosis. Retrospectively analyzed the year- round data of our center. Study was undertaken to analyze the incidence, frequency and type of arrhythmias in ACS. This is to aid timely intervention and to modify the outcome. Identification of the type of arrhythmia is of therapeutic and prognostic importance.Methods: This cross sectional analytical study was conducted in the Department of Cardiology, Apollo Hospitals Dhaka, from January 2019 to January 2020 with ACS patients. Enrolled consecutively and data analyzed.Results: There were 500 patients enrolled considering inclusion and exclusion criteria. Sample was subdivided into 3 groups on the type of ACS. Group-I with UA, Group-II with NSTE - ACS and Group-III with STE - ACS. Different types of arrhythmia noted. Types of arrhythmia were correlated with type of ACS. 500 patients included. Mean age 55.53±12.70, 71.6% male and 28.4% female. 60.4% hypertensive, 46.2% diabetic, 20.2% positive family history of CAD, 32.2% current smoker, 56.4% dyslipidaemic and 9.6% asthmatic. 31.2% UA, 39.2% NSTE-ACS and 29.6% STE-ACS. Type of arrhythmias noted. 22% sinus tachycardia, 20.2% sinus bradycardia, 9% atrial fibrillation, 5.2% ventricular ectopic, 4.8% supra ventricular ectopic, 2.8% bundle branch block, 2.2% atrio-ventricular block, 1% broad complex tachycardia, 0.4% narrow complex tachycardia, 0.2% sinus node dysfunction and 32.2% without any arrhythmia. Significant incidences of arrhythmia detected - respectively 29.8%, 39.2% and 31%, p<0.001.Conclusions: In conclusion, arrhythmias in ACS are common. More attention should be paid to improve their treatment and prognosis

Debt-repayment capacity and projected adjustments for irrigated farms with a declining water level in an area of the Texas High Plains

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Goblet Cells and Mucins: Role in Innate Defense in Enteric Infections

Goblet cells reside throughout the gastrointestinal (GI) tract and are responsible for the production and preservation of a protective mucus blanket by synthesizing and secreting high molecular weight glycoproteins known as mucins. The concept of the mucus layer functioning as a dynamic protective barrier is suggested by studies showing changes in mucins in inflammatory conditions of the GI tract, by the altered goblet cell response in germ-free animals, and by the enhanced mucus secretion seen in response to infections. The mucin-containing mucus layer coating the GI epithelium is the front line of innate host defense. Mucins are likely to be the first molecules that invading pathogens interact with at the cell surface and thus, can limit binding to other glycoproteins and neutralize the pathogen. This review will focus on what is known about goblet cell response in various GI infections and the regulatory networks that mediate goblet cell function and mucin production in response to intestinal insults. In addition, we describe the current knowledge on the role of mucins in intestinal innate defense. It is the aim of this review to provide the readers with an update on goblet cell biology and current understanding on the role of mucins in host defense in enteric infections

5-HT7 receptor signaling: improved therapeutic strategy in gut disorders

Serotonin (5-hydroxytrytamine; 5-HT) is most commonly known for its role as a neurotransmitter in the central nervous system. However, the majority of the body’s 5-HT is produced in the gut by enterochromaffin (EC) cells. Alterations in 5-HT signaling have been associated with various gut disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and enteric infections. Recently, our studies have identified a key role for 5-HT in the pathogenesis of experimental colitis. 5-HT7 receptors are expressed in the gut and very recently, we have shown evidence of 5-HT7 receptor expression on intestinal immune cells and demonstrated a key role for 5-HT7 receptors in generation of experimental colitis. This review summarizes the key findings of these studies and provides a comprehensive overview of our current knowledge of the 5-HT7 receptor in terms of its pathophysiological relevance and therapeutic potential in intestinal inflammatory conditions, such as IBD

Physico-Chemical Analysis and Composition of Camel Milk of Bangladesh

Camel farming is increasing in Bangladesh but the nutritious value of the produced milk has not been studied in this geological location. The milk was coagulated by citric acid and the coagulated solid i.e. the casein (7%) and pure serum (14%) were obtained. Fat content was determined by extracting casein and the aqueous serum, separately with n-hexane and found 2.59% and 5.79%, respectively. The fatty acids in the fat from casein and serum were made into their methyl ester by saponification followed by esterification and analyzed by GC-FID. Palmitoleic, oleic and linoleic acids were predominant fatty acids found in the analyzed samples while stearic, arachidic, behenic and myristic acids were present as minor acids. Water, ash, nitrogen and lactose contents in the milk were 84%, 0.88%, 1.62% and 9.32%, respectively. The presence of vitamin B1, B2 and B6 were estimated by UV-VIS spectrophotometer and found 388, 64 and 116 ppm, respectively

Physico-Chemical Analysis and Composition of Camel Milk of Bangladesh

Camel farming is increasing in Bangladesh but the nutritious value of the produced milk has not been studied in this geological location. The milk was coagulated by citric acid and the coagulated solid i.e. the casein (7%) and pure serum (14%) were obtained. Fat content was determined by extracting casein and the aqueous serum, separately with n-hexane and found 2.59% and 5.79%, respectively. The fatty acids in the fat from casein and serum were made into their methyl ester by saponification followed by esterification and analyzed by GC-FID. Palmitoleic, oleic and linoleic acids were predominant fatty acids found in the analyzed samples while stearic, arachidic, behenic and myristic acids were present as minor acids. Water, ash, nitrogen and lactose contents in the milk were 84%, 0.88%, 1.62% and 9.32%, respectively. The presence of vitamin B1, B2 and B6 were estimated by UV-VIS spectrophotometer and found 388, 64 and 116 ppm, respectively

Autophagy: roles in intestinal mucosal homeostasis and inflammation

Abstract The intestinal mucosa is a site of multiple stressors and forms the barrier between the internal and external environment. In the intestine, a complex interplay between the microbiota, epithelial barrier and the local immune system maintains homeostasis and promotes a healthy gut. One of the major cellular catabolic processes that regulate this homeostasis is autophagy. Autophagy is required to maintain anti-microbial defense, epithelial barrier integrity and mucosal immune response. Dysregulation of the autophagy process causes disruption of several aspects of the intestinal epithelium and the immune system that can lead to an inappropriate immune response and subsequent inflammation. Genome-wide association studies have found an association between several risk loci in autophagy genes and inflammatory bowel disease. The aim of the current review is to provide an update on the role of autophagy in intestinal mucosal physiology and in the control of inappropriate inflammation

Trichuris muris Model: Role in Understanding Intestinal Immune Response, Inflammation and Host Defense

Several parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths. Trichuris trichiura is one of the world’s most common intestinal parasites that causes human parasitic infections. Trichuris muris, as an immunologically well-defined mouse model of T. trichiura, is extensively used to study different aspects of the innate and adaptive components of the immune system. Studies on T. muris model offer insights into understanding host immunity, since this parasite generates two distinct immune responses in resistant and susceptible strains of mouse. Apart from the immune cells, T. muris infection also influences various components of the intestinal tract, especially the gut microbiota, mucus layer, epithelial cells and smooth muscle cells. Here, we reviewed the different immune responses generated by innate and adaptive immune components during acute and chronic T. muris infections. Furthermore, we discussed the importance of studying T. muris model in understanding host–parasite interaction in the context of alteration in the host’s microbiota, intestinal barrier, inflammation, and host defense, and in parasite infection-mediated modulation of other immune and inflammatory diseases

THE ROLE OF THE CLOCK GENE BMAL1 IN INFLAMMATORY BOWEL DISEASE

The circadian clock is a highly conserved molecular system that drives the oscillation of biological rhythms with a 24 hour period. Disruption of the circadian clock has been shown to cause an increased risk of Inflammatory Bowel Disease (IBD). Patients with IBD experience chronic inflammation along with impaired regeneration of intestinal epithelial cells. Inflammation and regeneration have been shown to be closely linked. Based on previous literature, we can hypothesize that disruption in the circadian clock leads to an increase in IBD severity. In this study, we compared the regenerative response of intestinal epithelial cells in BMAL1+/+ mice (with a functional clock) and BMAL1-/- mice (without a functional clock) who have been given IBD. Dextran Sulfate Sodium (DSS) was applied to induce acute colitis in mice, acting as an effective model for ulcerative colitis: one of the two categories of IBD. We observe a drastic decrease in the survival of mice lacking functional BMAL1 that were treated with 4% DSS over 7 days. Disease activity and cytokine analyses reveal time-dependent severity in inflammatory response that is worse in BMAL1-/- mice. To test the circadian rhythm of IBD, we performed a 24 hour analysis comparing epithelial cell proliferation, cell death, and inflammation in colon tissue. Our results indicate a significant rhythmic expression of mitosis throughout the day in BMAL1+/+ mice while mitosis in BMAL1-/- mice is arrhythmic and at lower levels. Based on these results, poor regeneration during IBD is in part attributed to decreased and arrhythmic regeneration. These data provides insight into how the core clock affects the inflammatory and regenerative abilities of intestinal epithelial cells