NEAR RINGS ADMITTING CERTAIN DECOMPOSITION THEOREMS

In the present paper we shall investigate some decomposition theorems for near rings satisfying any one of the conditions; (1)  (2)whereare integers

Crime Detection Using Sentiment Analysis

Women and girls have been subjected to a great deal of violence and harassment in public locations around the country, ranging from stalking to abuse harassment and assault. This research paper examines the role of social media in improving women's safety in Indian cities, with a focus on the use of social media websites and apps such as Twitter, Facebook, and Instagram. This research also looks at how ordinary Indians can develop a sense of responsibility in Indian society so that we can focus on the protection of women in their surroundings. Tweets on the safety of women in Indian cities, which often include images and text as well as written phrases and quotations, can be used to send a message to the Indian youth culture and encourage them to take harsh action and punish those who harass women. Twitter and other Twitter handles that feature hash tag messages are extensively used throughout the world as a channel for women to share their feelings about how they feel when going to work or travelling by public transportation and what is their mental condition when they are surrounded by unknown males, and do they feel safe or not

TOPICAL ANTI-PSORIATIC NANOPARTICULATE DRUG DELIVERY SYSTEM

Objective: Development of effective drug delivery in the treatment of psoriasis is the major challenge for its successful management. To develop and assess the potential of Nanostructured Lipid Carriers (NLCs) enriched with the powdered leaves extracts of Azadirachta indica (AE), Lawsonia inermis (LE) and fruit extract of Mallotus philippensis (ME) in the management of psoriasis. Methods: Drug loaded NLCs were prepared via hot homogenization technique by adopting 23 factorial design with factors X1 as the concentration of lipids, X2 concentration of surfactants and X3 being the number of homogenization cycle. The responses Y1 and Y2 were particle size and zeta potential. The optimized batch was obtained from Surface response plot and was evaluated for zeta potential, % entrapment efficiency, % drug loading, Scanning Electron Microscopy(SEM), % in vitro diffusion of drugs from the NLCs, anti-lipid peroxidation and nitric oxide scavenging activities, cytotoxicity on HaCat cell lines, Mouse Tail and Rat ultraviolet ray B photodermatitis models for Psoriasis. Results: The optimized batch of NLCs was found within the nanosized range with a relatively low polydispersity index and zeta potential of-20mV. The %EE for an optimized batch of NLCs was found to be 98.97±0.83%, 96.99±0.56% and 99.25±0.55% and the %DL of 21.84±0.15%, 8.55±045%, and 87.91±0.38% respectively for AE, LE and ME. The SEM images showed the spherical vesicular structures of drugs loaded NLCs. The in-vitro diffusion of drugs from the NLCs followed initial burst release thereafter sustained release for 24 h. The AE, LE and ME loaded NLCs proved to possess anti-lipid peroxidation and nitric oxide scavenging activities, cytotoxicity on HaCat cell lines, DNA fragmentation on HaCat cell lines which are biomarkers in the pathogenesis of psoriasis. The results of Mouse Tail and Rat ultraviolet ray B photodermatitis models for Psoriasis supported the anti-psoriatic potential of AE, LE and ME loaded NLCs. Conclusion: AE, LE and ME loaded NLCs can be used for prolonged topical delivery to the psoriatic skin for an effective treatment

DEVELOPMENT AND CHARACTERIZATION OF TOPICAL NANOPARTICULATE ANTIPSORIATIC POLYHERBAL CREAM

Objective: The lack of possible cure and associated disadvantages of allopathic medicines in the topical treatment of psoriasis has led to extensive research for anti-psoriatic activities of plant-based drugs. The present study was aimed to develop topical cream formulation containing the Nanostructured Lipid Carriers of Azadirachta indica leaves extract (AE), Lawsonia inermis leaves extract (LE) and fruit extract of Mallotus philippensis (ME) and assessing the antipsoriatic activity of prepared cream formulation. Methods: The Drug loaded NLCs were prepared via hot homogenization technique and incorporated into the water in oil (w/o) cream base that was prepared by the emulsification method. Evaluation of cream formulation included advanced preclinical trials using Rat Ultraviolet Ray-B photodermatitis and Mousetail method, anti-lipid peroxidation assay, nitric oxide scavenging activity, cytotoxicity and DNA fragmentation on HaCat cell lines to ascertain antipsoriatic potential and in vitro drug diffusion. Results: In spite of the low amount of the drug loading in NLCs their potency was much higher as displayed in Advanced Preclinical studies and cell line studies for psoriasis indicating the suitability of NLCs loaded creams for skin applications due to their various desirable effects on the skin. Occlusive properties of the prepared NLC on the skin provide an increase in drug penetration particularly via skin moisturization. The in vitro drug diffusion studies suggest the prolonged and almost complete release of AE, LE and ME from NLC based cream up to 24 h that was found to be 81.24±0.51%, 74.31±0.25% and 70.43±0.78% respectively. The literature survey supports the novelty of such topical anti-psoriatic polyherbal nanoparticulate cream. Conclusion: It can be concluded that the AE, LE and ME loaded NLC based cream can be used for prolonged topical delivery of drugs for the management of Psoriasis

An Evaluation Of Short-Term Prognostic Significance Of Various Clinical Parameters In Patients Of Stroke

Sonali Saxena', Shadab A. Khan", Jalaj Saxena’" * Consultant Cardiologist, ** Professor (Medicine), *** Assistant Professor (Physiology) Ishwardevi Medical and Cardiology Centre, Kanpur J.N. Medical College, A.M.U., Aligarh and G.S.V.M. Medical College, Kanpur ABSTRACT: Objectives :To predict the short-term prognostic significance of various clinical parameters at the time of admission in patients of stroke. Setting: Department of General Medicine, J.N. Medical College, A.M.U., Aligarh Participants : 100 patients of stroke (Cerebro-vascular accident) comprising 54 males and 46 females. Clinical Parameters : Admission Blood Pressure, Side of paralysis, Extent of Paralysis, Gastro-intestinal Haemorrhage, Level of consciousness at the time of admission. Statistical Analysis: ‘Z’ test (Z>_ 1.96). Results : The admission B.P. was raised in 75% of patients. The mortality was significantly high (57.1%) in the severe grade B.P. while recovery was significantly high (64.3%) in mild or moderate grade B.P patients. The left sided paralysis was having significantly high mortality of patients (49%) while recovery was significantly high (56.2%) in the patients with right sided paralysis. The paralysis with Grade O power was in 58% of stroke patients and was associated with signifi­cantly high (53.4%) mortality while 100% recovery was found in patients with power grade 4 and 5 at the time of admission. The G.l. haemorrhage was associated with 5% of patients but mortality was significantly high (100%) in these patients. The level of consciousness of grade / was highest (34%) while mortality was significantly high (100%) in the patients admitted with grade 3 level of consciousness. The recovery was significantly high (92.9%) in the patients admitted with grade 'O’ level of consciousnes

AVERMECTIN PRODUCTION BY SOLID STATE FERMENTATION-A NOVEL APPROACH

Objective: The present study was carried out to evaluate SSF process for the production of avermectin by Streptomyces avermitilis NRRL 8165 using easily available grains, millets and some agricultural by-product.Methods: Various substrates were screened for their ability to support avermectin production. Different parameters to maximize the yield of avermectin by S. avermitilis NRRL 8165 under SSF were optimized by conventional one factor at a time approach and parameters optimized earlier were adopted for the subsequent study.Results: Sorghum seeds used as solid substrate supported maximum growth and total avermectin production (4.6 mg g-1 dry substrate). The optimum values for maximum avermectin production were: moistening medium containing g l-1 KH2PO4 1; MgSO4.7H2O 0.4, inoculum size 20 % (24 h old culture in yeast extract-malt extract dextrose medium) v/w of initial dry substrate, substrate particle size 0.5 to 4 mm, incubation temperature 28 °C, initial moisture level 105%, incubation period of 15 d, 8 % w/w sucrose and 5% w/w soyameal. The avermectin yield with optimized fermentation condition was 5.8 mg g-1 dry substrate which is 1.3 fold higher as compared to non-optimized condition.Conclusion: Avermectin produced by S. avermitilis are widely used as an anthelmintic agent in the medical, veterinary and agricultural applications. In comparison with submerged fermentation, SSF can become an alternative cost-effective method for the production of avermectin. This report demonstrates the feasibility of employing agro-based substrate, that could reduce antibiotics production cost

Per Pattern-based Calibration Method for EIT Systems

A calibration approach has been developed for use with the EIT systems that are significantly influenced by parasitic impedances associated with switches, multiplexers and channel-to-channel coupling. Calibrated data acquired from saline tank experiments is compared with the data obtained from a forward simulation of the experiment