2-(Phenyl­sulfan­yl)pyridine-3-carboxylic acid

The title compound, C12H9NO2S, belongs to the nitro­gen-containing group of heterocyclic organic compounds and crystallized with two mol­ecules per asymmetric unit. In the crystal, both molecules form inversion dimers linked by pairs of O—H—O hydrogen bonds. Weak symmetry-related C—H—O inter­actions link the carboxyl dimers along b axis. The dihedral angle between the two aromatic rings in the two mol­ecules are 55.75 (14) and 58.33 (13)°

5H-Thio­chromeno[2,3-b]pyridine-5,10,10-trione

The asymmetric unit of the title compound, C12H7NO3S, contains two independent mol­ecules with different geometric­al configurations. The dihedral angles between the benzene and pyridine rings in the two mol­ecules are 3.7 (2) and 5.40 (19)°. The central heterocyclic fused rings have different puckering parameters [Q = 0.122 (3) Å, θ = 100.4 (13), ϕ = 185.3 (19)° in one mol­ecule, 0.101 (3) Å, 101.4 (3) and 2 (2)° in the other]. The SO2 group is oriented at dihedral angles of 81.06 (14) and 82.58 (15)° with the benzene and pyridine rings, respectively, in one mol­ecule [87.21 (14) and 87.66 (14)° in the second]. In the crystal, the mol­ecules are linked into zigzag polymeric chains along the b axis by inter­molecular C—H⋯O hydrogen bonding. π–π inter­actions with centroid–centroid distances in the range 3.825 (3)–4.153 (3) Å stabilize the structure. S—O⋯π and C—O⋯π inter­actions are also observed

6-Benzyl­sulfanyl-9H-purine

The phenyl ring of the title compound, C12H10N4S, a purine derivative, is oriented at a dihedral angle of 76.65 (6)° with respect to the purine ring system. An inter­molecular N—H⋯N hydrogen bonds stabilizes the crystal structure

Synthesis and antibacterial activity of 2-phenyl-5-aryl-4, 5, 6, 7, 8, 9-hexahydro-1,2.4-triazolo[1,5-A]quinazolines

A method for the synthesis of 2-phenyl-5-aryl-4, 5, 6, 7, 8,9- hexahydrotriazolo[1,5-a] quinazolines was developed.3-Amino-5-phenyl-1,2,4-triazole formed Schiff’s bases with aromatic aldehydes which on treatment with cyclohexanonein the presence of glacial acetic acid and anhydrous zinc chloride cyclized to produce title compounds.The structures of synthesized compounds were elucidatedby spectroscopic techniques (FTIR and 1H-NMR) and elementalanalysis. The compounds were also screened for their antibacterial activities against four different bacterial strains by agar plate disc method

1-(5-Hydr­oxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone: a new monoclinic polymorph

The title compound, C12H12N2O2, crystallized in the monolinic space group P21/n, with two independent mol­ecules (A and B) in the asymmetric unit. This is in contrast to the first monoclinic polymorph reported [Cingolani et al. (2002 ▶). Inorg. Chem. 41, 1151–116], which crystallized in the space group C2/c with one independent mol­ecule per asymmetric unit. The dihedral angles between the two rings differ slightly; in mol­ecule A it is 4.90 (11)° and in mol­ecule B it is 16.05 (13)°. In both mol­ecules, there is an intra­molecular O—H⋯O hydrogen bond involving the hydroxyl substituent and the carbonyl O atom of the adjacent acetyl group. In the crystal structure, mol­ecules A and B are linked via a C—H⋯N inter­action. There are also some weak C—H⋯π inter­actions involving the phenyl ring of mol­ecule A and H atoms of the acetyl groups of both mol­ecules

N′-[(E)-Benzyl­idene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide

In the title compound, C19H18N4O2, the 1,8-naphthyridine ring system is essentially planar [r.m.s. deviation = 0.011 (3) Å]. The dihedral angle between the naphthyridine ring system and the phenyl ring is 28.95 (7)°. The carbohydrazide H atom is involved in an intra­molecular N—H⋯O hydrogen bond, forming a six-membered hydrogen-bonded ring. In the crystal, the mol­ecules arrange themselves into centrosymmetric dimers by means of inter­molecular C—H⋯O hydrogen bonds

Synthesis of pyrimidines, aromatic and heteroaromatic acids as Biginelli reaction catalysts

Aromatic as well as heteroaromatic acids were found to beexcellent catalysts for the Biginelli three component synthesisof dihydropyrimidinones. Benzoic acid, substituted benzoic acids, five- and six- membered heterocyclic acids can be used for this purpose

Diethyl 5-acetamido-3-methyl­thio­phene-2,4-dicarboxyl­ate

The title compound, C13H17NO5S, is approximately planar (r.m.s. deviation for the non-H atoms = 0.055 Å). Its conformation is stabilized by N—H⋯O and C—H⋯O hydrogen bonds, which both generate S(6) rings. The crystal packing only features van der Waals contacts

Synthesis and antibacterial activities of Diarylpyrazolo [3,4-b]pyridines II1

Synthesis of various 4,6-diarylpyrazolo[3,4-b]pyridines, from aminopyrazoles and 1,3-dicarbonylcompounds or by a Doebner method are reported