69 research outputs found
2-(Phenylsulfanyl)pyridine-3-carboxylic acid
The title compound, C12H9NO2S, belongs to the nitrogen-containing group of heterocyclic organic compounds and crystallized with two molecules per asymmetric unit. In the crystal, both molecules form inversion dimers linked by pairs of O—H—O hydrogen bonds. Weak symmetry-related C—H—O interactions link the carboxyl dimers along b axis. The dihedral angle between the two aromatic rings in the two molecules are 55.75 (14) and 58.33 (13)°
5H-Thiochromeno[2,3-b]pyridine-5,10,10-trione
The asymmetric unit of the title compound, C12H7NO3S, contains two independent molecules with different geometrical configurations. The dihedral angles between the benzene and pyridine rings in the two molecules are 3.7 (2) and 5.40 (19)°. The central heterocyclic fused rings have different puckering parameters [Q = 0.122 (3) Å, θ = 100.4 (13), ϕ = 185.3 (19)° in one molecule, 0.101 (3) Å, 101.4 (3) and 2 (2)° in the other]. The SO2 group is oriented at dihedral angles of 81.06 (14) and 82.58 (15)° with the benzene and pyridine rings, respectively, in one molecule [87.21 (14) and 87.66 (14)° in the second]. In the crystal, the molecules are linked into zigzag polymeric chains along the b axis by intermolecular C—H⋯O hydrogen bonding. π–π interactions with centroid–centroid distances in the range 3.825 (3)–4.153 (3) Å stabilize the structure. S—O⋯π and C—O⋯π interactions are also observed
6-Benzylsulfanyl-9H-purine
The phenyl ring of the title compound, C12H10N4S, a purine derivative, is oriented at a dihedral angle of 76.65 (6)° with respect to the purine ring system. An intermolecular N—H⋯N hydrogen bonds stabilizes the crystal structure
Synthesis and antibacterial activity of 2-phenyl-5-aryl-4, 5, 6, 7, 8, 9-hexahydro-1,2.4-triazolo[1,5-A]quinazolines
A method for the synthesis of 2-phenyl-5-aryl-4, 5, 6, 7, 8,9- hexahydrotriazolo[1,5-a] quinazolines was developed.3-Amino-5-phenyl-1,2,4-triazole formed Schiff’s bases with aromatic aldehydes which on treatment with cyclohexanonein the presence of glacial acetic acid and anhydrous zinc chloride cyclized to produce title compounds.The structures of synthesized compounds were elucidatedby spectroscopic techniques (FTIR and 1H-NMR) and elementalanalysis. The compounds were also screened for their antibacterial activities against four different bacterial strains by agar plate disc method
1-(5-Hydroxy-3-methyl-1-phenyl-1H-pyrazol-4-yl)ethanone: a new monoclinic polymorph
The title compound, C12H12N2O2, crystallized in the monolinic space group P21/n, with two independent molecules (A and B) in the asymmetric unit. This is in contrast to the first monoclinic polymorph reported [Cingolani et al. (2002 ▶). Inorg. Chem.
41, 1151–116], which crystallized in the space group C2/c with one independent molecule per asymmetric unit. The dihedral angles between the two rings differ slightly; in molecule A it is 4.90 (11)° and in molecule B it is 16.05 (13)°. In both molecules, there is an intramolecular O—H⋯O hydrogen bond involving the hydroxyl substituent and the carbonyl O atom of the adjacent acetyl group. In the crystal structure, molecules A and B are linked via a C—H⋯N interaction. There are also some weak C—H⋯π interactions involving the phenyl ring of molecule A and H atoms of the acetyl groups of both molecules
N′-[(E)-Benzylidene]-1-ethyl-7-methyl-4-oxo-1,4-dihydro-1,8-naphthyridine-3-carbohydrazide
In the title compound, C19H18N4O2, the 1,8-naphthyridine ring system is essentially planar [r.m.s. deviation = 0.011 (3) Å]. The dihedral angle between the naphthyridine ring system and the phenyl ring is 28.95 (7)°. The carbohydrazide H atom is involved in an intramolecular N—H⋯O hydrogen bond, forming a six-membered hydrogen-bonded ring. In the crystal, the molecules arrange themselves into centrosymmetric dimers by means of intermolecular C—H⋯O hydrogen bonds
Synthesis of pyrimidines, aromatic and heteroaromatic acids as Biginelli reaction catalysts
Aromatic as well as heteroaromatic acids were found to beexcellent catalysts for the Biginelli three component synthesisof dihydropyrimidinones. Benzoic acid, substituted benzoic acids, five- and six- membered heterocyclic acids can be used for this purpose
Diethyl 5-acetamido-3-methylthiophene-2,4-dicarboxylate
The title compound, C13H17NO5S, is approximately planar (r.m.s. deviation for the non-H atoms = 0.055 Å). Its conformation is stabilized by N—H⋯O and C—H⋯O hydrogen bonds, which both generate S(6) rings. The crystal packing only features van der Waals contacts
Synthesis and antibacterial activities of Diarylpyrazolo [3,4-b]pyridines II1
Synthesis of various 4,6-diarylpyrazolo[3,4-b]pyridines, from aminopyrazoles and 1,3-dicarbonylcompounds or by a Doebner method are reported
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