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Synthesis and antibacterial activity of 2-phenyl-5-aryl-4, 5, 6, 7, 8, 9-hexahydro-1,2.4-triazolo[1,5-A]quinazolines

Abstract

A method for the synthesis of 2-phenyl-5-aryl-4, 5, 6, 7, 8,9- hexahydrotriazolo[1,5-a] quinazolines was developed.3-Amino-5-phenyl-1,2,4-triazole formed Schiff’s bases with aromatic aldehydes which on treatment with cyclohexanonein the presence of glacial acetic acid and anhydrous zinc chloride cyclized to produce title compounds.The structures of synthesized compounds were elucidatedby spectroscopic techniques (FTIR and 1H-NMR) and elementalanalysis. The compounds were also screened for their antibacterial activities against four different bacterial strains by agar plate disc method

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