7 research outputs found

    Obesity and Diabetes Mediated Chronic Inflammation: A Potential Biomarker in Alzheimer’s Disease

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    Alzheimer’s disease (AD) is the sixth leading cause of death and is correlated with obesity, which is the second leading cause of preventable diseases in the United States. Obesity, diabetes, and AD share several common features, and inflammation emerges as the central link. High-calorie intake, elevated free fatty acids, and impaired endocrine function leads to insulin resistance and systemic inflammation. Systemic inflammation triggers neuro-inflammation, which eventually hinders the metabolic and regulatory function of the brain mitochondria leading to neuronal damage and subsequent AD-related cognitive decline. As an early event in the pathogenesis of AD, chronic inflammation could be considered as a potential biomarker in the treatment strategies for AD

    Body Composition Changes In Female Apoe*3Leiden.Cetp Transgenic Mice After 5-Week Injection Of Resveratrol-Encapsulated Liposomes To Inguinal White Adipose Tissue (P21-041-19)

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    Objectives Many cell culture and animal studies have demonstrated that Trans-resveratrol (R) has the potential to induce beige cell formation and activity. Although human studies indicate that R can maintain metabolic health, evidence is inconclusive regarding its browning effectiveness mainly due to its low aqueous solubility and high hepatic metabolism in humans. To combat the shortcomings of R, we have successfully synthesized biocompatible and biodegradable R-encapsulated liposomes (Rlipo). We will directly inject Rlipo into inguinal white adipose tissue (iWAT) in this project. The purpose of this study to evaluate the anti-obesity effects of resveratrol-encapsulated liposomes in female APOE*3Leiden.CETP transgenic mice, which have human-like lipoprotein metabolism. Methods Rlipo was prepared using R and soy phosphatidylcholine (soy-PC) dissolved in ethanol. After mixing and drying with nitrogen, deionized water was added followed by a sonication step. Ultrafiltration was used to remove any unencapsulated R. The void liposomes (Vlipo) were prepared using only soy-PC., Female APOE*3Leiden.CETP mice (n = 40) were fed with a high fat diet (45% of calorie from fat) throughout the study. After 4 weeks of the high-fat diet administration, mice were randomly divided into 4 groups (n = 10) and received iWAT injections of Rlipo, Vlipo, free R and saline (control) once per week for 5 weeks. R concentration was 17.5 mg/kg body weight/week. Body weight and food intake were measured weekly. Body composition of mice was measured using an EchoMRITM every other week. Paired sample t-test and One-way ANOVA were used to analyze differences between means. Results After 5-weeks of treatment compared to baseline, fat percentage differences were 1.99 ± 0.93%, 1.85 ± 0.58%, 1.45 ± 0.67%, and 1.40 ± 0.68% in control, free R, Vlipo and Rlipo groups, respectively. Body weight and fat mass showed a similar trend of change. Although control group showed an increase in lean mass (0.25 ± 0.95 g), RLipo group showed a decrease (−0.14 ± 0.52 g). Food intake was similar among four groups. Conclusions Nanoencapsulation of R can enhance R's anti-obesity effects. However longer treatment time might be necessary to see more prominent results. Funding Sources NIH/NCCIH (Grant R15AT008733).PubMe

    Prevalence and determinants of physical violence against doctors in Bangladeshi tertiary care hospitals

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    Abstract Background The increasing physical violence against doctors in the health sector has become an alarming global problem and a key concern for the health system in Bangladesh. This study aimed to determine the prevalence and associated factors of physical violence against doctors in Bangladeshi tertiary care hospitals. Methods A cross-sectional survey was performed among 406 doctors working in tertiary care hospitals. Data were collected using a self-administered questionnaire and the binary logistic regression model was employed for predicting physical violence against doctors. Results Of the participants, 50 (12.3%) doctors reported being exposed to physical violence in 12 months prior to the survey. According to logistic regression analysis, aged less than 30 years or younger, male and never-married doctors were prone to physical violence. Similarly, doctors from public hospitals and those worked in emergency departments were at higher risk of physical violence. More than 70% of victims reported that patients’ relatives were the main perpetrators. Two-thirds of the victims referred to violence in the hospitals as a grave concern. Conclusions Physical violence against doctors is relatively common in the emergency departments and public hospitals in Bangladesh. This study found that male and younger doctors were at high risk of exposing physical violence. To prevent hospital violence, authorities must develop human resources, bolster patient protocol and offer physician training

    Effect of Cow Manure on Growth, Yield and Nutrient Content of Mungbean

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    The experiment was conducted at the farm of Sher-e-Bangla Agricultural University, Sher-e-Bangla Nagar, Dhaka, Bangladesh during the period from March to June 2014 to study the effect of cowdung on the growth, yield and nutrient content of mungbean (Vigna radiata L.). The variety BARI Mung-5 was used as the test crop. The experiment consist of single factor: Cowdung (3 levels); C0: 0 ton cowdung ha-1 (control), C1: 5 ton cowdung ha-1 and C2: 10 ton cowdung   ha-1. The experiment was laid out in Randomized Complete Block Design (RCBD) with five replications. Data on different growth parameters and yield showed statistically significant variation for different levels of cowdung. The tallest plant, the highest number of leaves plant-1, the highest number of branches plant-1, the minimum number of days required for 1st flowering, the minimum number of days required for 80% pod maturity, the highest number of pods plant-1, the highest number of seeds pod-1, the longest pod, the maximum weight of 1000-seeds, the highest seed yield, the highest stover yield and nitrogen, phosphorus, potassium and sulphur content in seeds were recorded from 10 ton cowdung ha-1, whereas the lowest value was found from control treatment

    Energy challenges for a clean environment: Bangladesh’s experience

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    A significant progress has been made to increase electricity generation capacity in the country over the last decade. The electricity supply for growing demand is the foremost challenge of the government, as the country move towards the vision of middle-income status by 2021 and high-income by 2041. The energy security is the concern due the running out of gas supply soon. Despite significant progress on energy in recent years, the goal of access to electricity for all would not be attainable without implementation of a consistent national energy policy. Well-coordinated national energy policy is required to achieve sustainable development goals of the country. Priorities for action and regulatory framework of energy need to identify to overcome energy crisis. Long-term energy planning and private financing policy are also crucial to extend the pace of progress in the energy sector. This review provides insights into the energy policies at different sectors, notably coal fired electricity in Bangladesh. The results revealed that the effective and efficient CO2 emission could be reduced from power generating sector by introducing advanced fuel technologies and management system. Besides, higher thermal and mechanical efficiency can be obtained by initiating the combined power cycle systems in energy sector. The achievement in energy sector as well as challenges facing in ensuring sustainable energy is highlighted. The key challenges in the existing legal framework and substantial progress improving energy efficiency are also discussed in this review
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