Comprehensive Performance Analysis of Neurodegenerative disease Incidence in the Females of 60-96 year Age Group

Neurodegenerative diseases such as Alzheimer's disease and dementia are gradually becoming more prevalent chronic diseases, characterized by the decline in cognitive and behavioral symptoms. Machine learning is revolu-tionising almost all domains of our life, including the clinical system. The application of machine learning has the potential to enormously augment the reach of neurodegenerative care thus building it more proficient. Throughout the globe, there is a massive burden of Alzheimer's and demen-tia cases; which denotes an exclusive set of difficulties. This provides us with an exceptional opportunity in terms of the impending convenience of data. Harnessing this data using machine learning tools and techniques, can put scientists and physicians in the lead research position in this area. The ob-jective of this study was to develop an efficient prognostic ML model with high-performance metrics to better identify female candidate subjects at risk of having Alzheimer's disease and dementia. The study was based on two diverse datasets. The results have been discussed employing seven perfor-mance evaluation measures i.e. accuracy, precision, recall, F-measure, Re-ceiver Operating Characteristic (ROC) area, Kappa statistic, and Root Mean Squared Error (RMSE). Also, a comprehensive performance analysis has been carried out later in the study

An Exploratory Study to Find the Early Trend and Pattern Recognition of COVID-19 Infection in India: A Severity Model-Based Prediction

Background: Recent Coronavirus Disease 2019 (COVID-19) pandemic has inflicted the whole world critically. Although India has been listed amongst the top ten highly affected countries to date, one cannot rule out COVID-19 associated complications in the near future. Aim & Objective: We aim to build the COVID-19 severity model employing logistic function which determines the inflection point and help in the prediction of the future number of confirmed cases. Methods and Material: An empirical study was performed on the COVID-19 patient status in India. We performed the study commencing from 30 January 2020 to 12 July 2020 for the analysis. Exploratory data analysis (EDA) tools and techniques were applied to establish a correlation amongst the various features. The acute stage of the disease was mapped in order to build a robust model. We collected five different datasets to execute the study. Results: We found that men were more prone to get infected with the coronavirus disease as compared to women. On 165-days based analysis, we found a trending pattern of confirmed, recovered, deceased and active cases of COVID-19 in India. The as-developed growth model provided an inflection point of 72.0 days. It also predicted the number of confirmed cases as 17,80,000.0 in the future i.e. after 12th July. A growth rate of 32.0 percent was obtained. We achieved statistically significant correlations amongst growth rate and predicted COVID-19 confirmed cases. Conclusions: This study demonstrated the effective application of EDA and analytical modeling in building a mathematical severity model for COVID-19 in India

Policy Response to the Tourism Crisis during the COVID-19 Pandemic : A Meta Policy Analysis of Select Countries

The Pandemic cracked the fragile mold of what was decided as the norm and pushed countries to resort to survival. Tourism, a mechanism proven to bridge gaps between cultures was worst affected on a global level and the only flotation device utilized were policies. Yet, States with different political ideologies, how have they responded in reality? Which ideology has become a tool to design the policy to address tourism crisis caused by the pandemic? remained an unexplored field of research. To address these questions there is a need to look at the policies initiated by selected countries representing varied political spectrum to analyse the pragmatically working ideology during/after the pandemic. Therefore, this study aims to observe the complexities of crisis management and the shift of ideology between the usual state of government to the adoption of a foreign even opposing ideology to rebuild after an unprecedented catastrophe. To enunciate its shift, the methodology divides its countries into ideologies based on liberal, socialist, and conservative categories and selects two countries each of which are contributing a major portion of GDP share to the tourism industry. The study had adopted the ideological approach to examine the select policies formulated by the respective countries to revive their tourism industry such as what are the bail-out programmes, financial aids, etc. The present study relied on a meta-analysis approach to identify, summarize, and analyze how the selected countries adopted different models to identify and define policy problems. Based on the findings of the meta-analysis, the study establishes that countries adopted ideologies that pragmatically worked and rejected ideologies that are inherently adopted as the state’s governing principle

A preservative with bleaching and emulsifying effects

In cosmetic products, additives are substances that aren’t consumed as main ingredients, actually, they are added to these products in the processes of preparation, packaging or storage in order to make them safer, improve their appearance, help to present a stable, attractive and easier to apply the product, without being stricken by environmental conditions [1, 2]. The protection and quality of toiletries or medicine products are important elements in regards to the health of the consumers. Adding preservatives to the formulations helps the cosmetic manufacturer achieve the first objective of products i.e. meeting the requirements of the users while being safe under normal conditions of use. Despite advances in manufacturing conditions (raw materials with exhaustive bacteriological controls and manufacturing in sterile areas), and the containers used (single-dose ampoules, opaque and hermetic bottles which are used for precise amount), there is still the possibility of colonizing cosmetics without a preservative in their composition. Principally adding extra compounds as emulsifier and blanching agent causes more noxious compounds in the products, which should be avoided. Hence, it is desirable that some components of the formulation fulfill this function [3]. In our study, a combination of sodium thiosulfate and Citric acid contains emulsifiers and bleaching substances. When this mixture was added to Azadirachta indica (Neem) gum or Acacia Senegal (Gum Arabic), besides the above-mentioned properties, turned these gums into a thickener and stabilizer agent. This formulation can prevent the spreading of microorganisms. It will be shown from the findings and results that this formula can be used as a preservative agent in the cosmetic and pharmaceutical industry with significant emulsifying and bleach potential. The rare side effect of this additive is mild skin hypersensitivity reaction only in sensitive individuals. Objective: The purpose of the study was to develop a powerful preservative based on synthetic and naturalingredients, with bleaching and emulsifying effects

Sacrospinous colpopexy versus McCall’s culdoplasty during vaginal hysterectomy in stage 3 and 4 prolapse for prevention of vault prolapse

Background: Pelvic organ prolapse is a common condition seen in women due to weakening of support of pelvic organs. Different surgical procedures have been adopted for suspension of vaginal vault during vaginal hysterectomy to restore vault to near normal anatomic position as preventive measures for vault prolapse. The aim of study was to compare the efficacy of the McCall’s culdoplasty and sacrospinous ligament colpopexy in stage 3 and 4 prolapse (POP-Q).Methods: This prospective study comprised 100 women presenting with stage 3 and 4 prolapse (POP-Q). They were divided into two equal groups of 50 each. The patients were randomized to undergo McCall’s culdoplasty (Group A) or sacrospinous ligament fixation (Group B) with vaginal hysterectomy based on note contained in an envelope comparative analysis was done, and patients were evaluated for intra-operative difficulties and immediate (48 hours) post-operative complications using SPSS-version 23 for statistical analysis. The patients were followed up at one month and one year to evaluate symptomatically and objectively.Results: In group A, patients with 3-degree prolapse 1 woman had hemorrhage and 1 woman had bladder injury intraoperatively. Whereas in group B, 5 women had hemorrhage and 1 woman had rectal injury intraoperatively. All complications were dealt successfully. No other major intra- and post-operative complications occurred.Conclusions: Vaginal hysterectomy with sacrospinous colpopexy resulted in better outcomes after surgery. Hence, it was concluded that unilateral or bilateral SSLF may be added to vaginal hysterectomy in patients of stage 3 or 4 prolapse

Prevalence Of Parafunctional Habits And Temporomandibular Disorder Symptoms In Young Individuals Reporting To Watim Dental Hospital

Objective: This study aims to identify the prevalence of parafunctional habits and common symptoms of temporomandibular disorders in young individuals reporting to the Watim Dental College Materials and methods: This cross-sectional study was carried out by a survey and clinical examination over a period of six months from September 2021 to February 2022. Data from 103 patients, who fulfilled the inclusion criteria, were collected using a structured questionnaire and clinical examination regarding their parafunctional habits and temporomandibular joint symptoms. Informed consent was filled out by all the participants. Data were analyzed using SPSS version 23. A descriptive analysis was calculated for both quantitative and qualitative variables. Results: The prevalence of oral parafunctional habits among the study sample was quantified on a binary scale (yes/no) where nail-biting was observed to be highly prevalent (38%), followed by mouth breathing (27%). The most frequently reported temporomandibular joint symptom was noise (clicking or crepitation)  which was 66%. Difficulty in mouth opening was the least common (20%) of all the symptoms noted. Conclusion: It may be concluded from our study that amongst parafunctional habits nail biting is the most common habit amongst young individuals and amongst the temporomandibular joint disorder clicking and crepitation is the most common symptom persistent with the condition. Keywords: clicking, nail-biting, parafunctional habits, temporomandibular joint symptom

Clinical profile of patients with pancytopenia in a tertiary care centre

Background: Pancytopenia is a condition in which all three cell lines i.e. erythroid, myeloid and megakaryocytic are affected resulting in anaemia, leukopenia and thrombocytopenia. It can be a manifestation of a wide variety of disorders which primarily or secondarily affect the bone marrow. Early diagnosis of these conditions will help in implementing the appropriate treatment. The objective of the study was to know the clinical presentation and etiology of patients presenting with pancytopenia.Methods: A one year study from April 2016 to March 2017 was conducted in the department of medicine at a tertiary care centre. Total 32 patients with pancytopenia were studied to determine their clinical features and etiology through relevant investigations.Results: Our study revealed megaloblastic anaemia (46.87%) as the most common cause of pancytopenia, followed by malaria (12.5%). Other causes included hypothyroidism (6.2%), hypersplenism (6.2%), drugs (12.5%) and miscellaneous (9.43%).Conclusions: Megaloblastic anaemia was found to be the major cause of pancytopenia in patients. Other causes of pancytopenia were malaria, drugs, hypersplenism and hypothyroidism. These should be kept in mind while evaluating patients with pancytopenia

A study on the effects of social media advertisement on consumer’s attitude and customer response

Given that Social Media Advertising put significant impact on Consumer’s attitude and shapes Customer’s buying behavior, so the managers of manufacturing industries of Pakistan should use the social media platform for their marketing activities. Concisely, we’ve got validated that Social media is becoming highly significant also as convenient for the businesses and helping them in using it as a tool for marketing, external promotions, customer management, and as an inside channel for employee communications. The study was involved with survey and analysis was conducted based on a total of 500 responses whereas most of the respondents were students who had experience in business sector and linked industry. The analysis used structural equation modeling to test the research model and hypothesis. The findings imply that Social Media Advertisement had significant impact on Consumer Attitude and Customer Response in business success, so the managers of manufacturing/business industries of Pakistan should use the social media platform for their marketing activities. As far as delimitations are concerned, this research focused on Social Media Advertising effects on consumer’s attitude and shapes customer buying behavior irrespective of other marketing tools. However, the data was collected from limited number of respondents, the study may contain biasness/unfairness because the results are self-reported and respondents may have answered inaccurately which may make the results less convincing

Body Dysmorphic Disorder: Gender differences and prevalence in a Pakistani medical student population

<p>Abstract</p> <p>Background</p> <p>Body dysmorphic disorder (BDD) is a psychiatric disorder characterized by a preoccupation with an imagined or slight defect which causes significant distress or impairment in functioning. Few studies have assessed gender differences in BDD in a non clinical population. Also no study assessed BDD in medical students. This study was designed to determine the point prevalence of BDD in Pakistani medical students and the gender differences in prevalence of BDD, body foci of concern and symptoms of BDD.</p> <p>Methods</p> <p>The medical students enrolled in a medical university in Karachi, Pakistan filled out a self-report questionnaire which assessed clinical features of BDD. BDD was diagnosed according to the DSM-IV criteria.</p> <p>Results</p> <p>Out of the 156 students, 57.1% were female. A total of 78.8% of the students reported dissatisfaction with some aspect of their appearance and 5.8% met the DSM-IV criteria for BDD. The male to female ratio for BDD was 1.7. Regarding gender differences in body foci of concern, the top three reported foci of concern in male students were head hair (34.3%), being fat (32.8%), skin (14.9%) and nose(14.9%), whereas in females they were being fat (40.4%), skin (24.7%) and teeth (18%). Females were significantly more concerned about being fat (p = 0.005). Male students were significantly more concerned about being thin (p = 0.01) and about head hair (p = 0.012).</p> <p>Conclusion</p> <p>BDD is fairly common in our medical student population, with a higher prevalence in males. Important gender differences in BDD symptomatology and reported body foci of concern were identified which reflected the influence of media on body image perception. The impact of cultural factors on the prevalence as well as gender differences in BDD symptomatology was also established.</p

Status of ToRCH positivity among the children presented with congenital Hydrocephalus

Introduction: ToRCH is an acronym for four congenital infections that are sometimes difficult to distinguish: Toxoplasmosis, Rubella, Cytomegalovirus (CMV), and Herpes Simplex Virus (HSV). This group of organisms produces serious Central Nervous System (CNS) and other infections, which are potentially preventable and treatable.&#x0D; Methods: Neonates and infants with hydrocephalus (N = 65) identified via the outpatient department of the National Institute of Neurosciences and Hospital (NINS&amp;H), were prospectively screened for ToRCH antibodies. Hydrocephalus secondary to Tumor or Trauma was excluded from this study.&#x0D; Results: Evidence of 75.38 % (p = &lt;0.05) patient was positive for TORCH antibodies. Toxoplasma Gondi (T. Gondii) IgG 18.5 % ( p= &lt;0.05 ), CMV IgM 9.2 % (p = &lt;0.05), CMV Ig G47.7% ( p = &lt;0.5), Rubella, and HSV 1 &amp; 2 antibodies were also identified.&#x0D; Conclusion: The vast majority of cases of neonatal hydrocephalus at one institution was post-infectious in etiology and related to ToRCH infections. Many of these cases could be prevented with improved screening and treatment. While study of a single institution may not be the representative of the entire population, further study and implementation of a standardized screening protocol would likely benefit this population.&#x0D; Bang. J Neurosurgery 2020; 9(2): 121-125</jats:p