Interstitial granulomatous dermatitis in a patient with systemic lupus erythematosus: First case report in Saudi Arabia

Interstitial granulomatous dermatitis (IGD) is an uncommon idiopathic dermatitis characterized by variable clinical presentation and a special histopathologic pattern. IGD is in some cases associated with autoimmune connective tissue diseases. Here we describe, IGD in a 35 year old Saudi female systemic lupus erythematosus patient. IGD lesions appeared as multiple asymptomatic erythematous annular plaques symmetrically distributed in the axillae, chest, abdomen and back. The lesions resolved totally within 2 months after systemic corticosteroid treatment

Hidden under a cauliflower-like growth: A case of cutaneous chromoblastomycosis and response to combination therapy

Chromoblastomycosis is a rare, chronic fungal infection of skin and subcutaneous tissue. It is caused by several pigmented fungi commonly seen in tropical and sub-tropical regions. Here, we report a case of chronic cutaneous chromoblastomycosis in a middle aged man from the southern part of Jizan, Saudi Arabia, who presented to our derma clinic with verrucous cauliflower like growth on the right hand. Later on, histopathological study showed pathognomonic characteristic brown colored spores (copper pennies or medlar bodies) of the fungus within dermal abscess. The patient was cured after a 6 month combination use of itraconazole and cryotherapy. Review of literature showed this is the first cutaneous chromoblastomycosis reported from Saudi Arabia

Recurrent non-healing perianal ulcer: A case of tuberculosis cutis orificialis

Tuberculosis cutis orificialis (TCO) is a rare manifestation of cutaneous tuberculosis. Due to its variable clinical features, the diagnosis may be missed at the onset of the disease. Here we describe, TCO as well as intestinal tuberculosis in a patient with recurrent non-healing perianal ulcer. First TCO was detected, later on intestinal T.B was also detected. The perianal lesions appeared as multiple outbreaks of ulcer which resolved totally after combined anti T.B treatment. The clinical course of intestinal lesions and tuberculosis cutis orificialis appeared interrelated

Juvenile xanthogranuloma: Late presentation of giant form ends with atrophic sequelae: Case report

Juvenile xanthogranuloma (JXG) is a histiocytic disorder that is usually benign and limited to the skin. Usually it regresses spontaneously, more often without or with limited skin changes. The systemic form of JXG is rare and may be associated with severe morbidity and mortality due to CNS involvement. Here, we describe a 15 year old boy with puzzling skin lesions evolving since last 6 months on the neck. A skin biopsy and immunohistochemistry confirmed the diagnosis of JXG

Cutaneous actinomycosis and long-term management through using oral and topical antibiotics: A case report

Actinomycosis is a subacute or chronic suppurative bacterial infection which caused because of filamentous gram-positive, anaerobic to microaerophilic nonacid fast bacilli primarily of the genus Actinomyces that normally colonize the mouth, colon, and vagina. Primary cutaneous actinomycosis is a rare entity and is generally associated with trauma. A 61- year-old Yemeni male firstly presented to the surgical department in King Fahd Central Hospital with multiple swelling, petted lesions and boring of sensation in the right foot. Local examination showed multiple erythematous nodules and plaques with discharge in the right leg, and active sinus was not determined

Association between type 2 diabetes mellitus-related SNP variants and obesity traits in a Saudi population

Obesity, commonly measured as body mass index (BMI), has been on a rapid rise around the world and is an underlying cause of several chronic non-communicable diseases, including type 2 diabetes mellitus (T2DM). In addition to the environmental factors, genetic factors may also contribute to the ongoing obesity epidemic in Saudi Arabia. This study investigated the association between variants of 36 previously established T2DM SNPs and obesity phenotypes in a population of Saudi subjects. Study subjects consisted of 975 obese (BMI: a parts per thousand yen30), 825 overweight (25-30) and 423 lean controls (18-25) and of these 927 had a history of T2DM. Subjects were genotyped for 36 SNPs, which have been previously proved to be T2DM linked, using the KASPar method and the means of BMI and waist circumference (WC) corresponding to each of the genotypes were compared by additive, recessive and dominant genetic models. Five and seven of 36 T2DM-related SNPs were significantly associated with the BMI and WC, respectively. Variants of SNPs rs7903146, rs1552224 and rs11642841 in the control group and rs7903146 in T2DM group showed significant association with both BMI and WC. Variant of SNP rs10440833 was significantly associated with BMI in T2DM group of both males [OR = 1.8 (1.0, 3.3); P = 0.04] and females [OR = 2.0 (1.0, 3.9); P = 0.04]. Genetic risk scores explained 19 and 14 % of WC and hip size variance in this population. Variants of a number of established T2DM related SNPs were associated with obesity phenotypes and may be significant hereditary factors in the pathogenesis of T2DM